Repetitive aggressive encounters generate a long-lasting internal state in
            <i>Drosophila melanogaster</i>
            males

Kim, Yong-Kyu; Saver, Mathias; Simon, Jasper C.; Kent, Clement F.; Shao, Lisha; Eddison, Mark; Agrawal, Pavan; Texada, Michael J.; Truman, James W.; Heberlein, Ulrike

doi:10.1073/pnas.1716612115

Cited by 47 publications

(51 citation statements)

References 41 publications

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“…Another possibility is that this difference may be explained by differences in courtship behaviour between winners and losers. In Drosophila, Kim et al [43] found that losers take around two times as long to initiate courtship when placed into a chamber with a virgin female, which may explain the difference that we observed in mating latency. Another interesting possibility may involve differences in cuticular hydrocarbon expression between winners and losers, which can significantly influence the outcomes of mating interactions [44].…”

Section: Discussionmentioning

confidence: 61%

Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes

Filice

Dukas

2019

Proc. R. Soc. B.

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In many animals, the outcomes of competitive interactions can have lasting effects that influence an individual's reproductive success and have important consequences for the strength and direction of evolution via sexual selection. In the fruit fly, Drosophila melanogaster, males that have won previous contests are more likely to win in subsequent conflicts and losers are more likely to lose (winner -loser effects), but the direct fitness consequences and genetic underpinnings of this plasticity are poorly understood. Here, we tested how male genotype and the outcomes of previous male-male conflicts influence male pre-and post-copulatory success. We quantified pre-copulatory success in a choice and no-choice context, and post-copulatory success by quantifying ejaculate offensive and defensive ability. We found that winners have higher reproductive success compared to losers in both pre-copulatory scenarios. However, losers consistently mated for a longer duration, boosted female fecundity and had an increased paternity share when they were the first males to mate, suggesting increased investment into post-copulatory mechanisms. Finally, by using clonal hybrids from the Drosophila Genetic Reference Panel, we documented that genetic variation explained a sizeable proportion of the observed differences between lines, and of the interaction between line and winner and loser effects. Our results place the behavioural data on winner -loser effects in an evolutionary context by documenting the potential fitness gain to males from altering their reproductive strategy based on fighting experience. Our data may also explain the presence and maintenance of trade-offs between different male reproductive strategies.

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Section: Discussionmentioning

confidence: 61%

Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes

Filice

Dukas

2019

Proc. R. Soc. B.

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“…Since male flies defend territories and compete over females they also display higher levels of aggression than females [164,355,[378][379][380][381]. A few neuropeptides have been found to play important roles in regulation of aggression in male Drosophila: NPF, TK and DH44 [164,355,358]. Also female flies can display aggressive behavior and this aggression increases in mated flies due to sex peptide that is transferred with sperm at copulation [356].…”

Section: Aggressionmentioning

confidence: 99%

“…Another peptide implicated in aggressive behavior is DH44. Knockdown of the DH44 receptor DH44R1 results in male flies that display increased aggressivity if they have been kept singly-housed, but are less aggressive after being kept in a group [358]. This paper provided no details on the DH44 neuron circuit.…”

Section: Aggressionmentioning

confidence: 99%

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Nässel

Zandawala

2019

Preprint

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This review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neuropeptides and peptide hormones in Drosophila, largely due to the rapid developments of powerful genetic methods, imaging techniques and innovative assays. We critically discuss the roles of peptides in olfaction, taste, foraging, feeding, clock function/sleep, aggression, mating/reproduction, learning and other behaviors, as well as in regulation of development, growth, metabolic and water homeostasis, stress responses, fecundity, and lifespan. We furthermore provide novel information on neuropeptide distribution and organization of peptidergic systems, as well as the phylogenetic relations between Drosophila neuropeptides and those of other phyla, including mammals. As will be shown, neuropeptide signaling is phylogenetically ancient, and not only are the structures of the peptides, precursors and receptors conserved over evolution, but also many functions of neuropeptide signaling in physiology and behavior.

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“…Moreover, the negatively-reinforcing MP1 DANs prevent the expression of appetitive memory in fed flies through a hunger state-dependent peptidergic mechanism (Krashes et al, 2009;Perisse et al, 2016). Finally, a recent study suggested that MP1 and MVP2 are required for the aversion of an odor associated to the repeated defeat in fights between male flies (Kim et al, 2018). Nevertheless, shi ts1mediated inactivation of the MP1 DAN neurons had no effect on perseverant odor tracking of the hungry animal (data not shown), suggesting the involvement of more or different, yet to be identified, DANs.…”

Section: Circuit Mechanisms and The Role Of The Mushroom Body Networkmentioning

confidence: 84%

A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila

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Backer

Wosniack

et al. 2018

Preprint

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Highlights• Lack of reward stimulates perseverance, and not quitting.• Dopaminergic neurons previously implicated in aversive learning promote perseverance.• Sugar responsive octopaminergic neurons counteract perseverant odor tracking behavior through a downstream inhibitory neuron.• Computational modeling supports a simple neural circuit featuring antagonistic functions for dopamine and octopamine as tallies of expense and gain.peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi:bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Feb. 2, 2018; peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/259119 doi: bioRxiv preprint first posted online Fe...

show abstract

Repetitive aggressive encounters generate a long-lasting internal state in Drosophila melanogaster males

Cited by 47 publications

References 41 publications

Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes

Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

A neural circuit arbitrates between perseverance and withdrawal in hungry Drosophila

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