Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model

Bhardwaj, Jyoti; Siddiqui, Arif Jamal; Goyal, Manish; Prakash, Kirtika; Soni, Awakash; Puri, Sunil K.

doi:10.1016/j.actatropica.2016.02.016

Cited by 14 publications

(8 citation statements)

References 49 publications

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“…Malaria, a very common disease globally with a high mortality rate, is caused by Plasmodium, a parasitic organism [121][122][123][124]. The parasite gets into the human body through the bites of infected mosquitoes [125][126][127].…”

Section: Cordycepin and Anti-malarial Effectmentioning

confidence: 99%

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

et al. 2020

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Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing.

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Section: Cordycepin and Anti-malarial Effectmentioning

confidence: 99%

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

et al. 2020

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“…Though we cannot bring about an instant cure, considering the urgency of eradicating the COVID-19 pandemic, this paper will open new perspectives about plant molecules in developing various strategies against infectious diseases [ 12 , 13 ]. Mother Nature has always been considered as the prime source for the discovery of unique and new bioactive compounds, which have helped in combatting various diseases and infections [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Medicinal plants are known to produce innumerable bioactive metabolites with different pharmacological properties, including anticancer, anti-inflammatory, antimicrobial, antioxidant, anti-malarial, anti-hypertension, anti-ageing, anti-diabetic, anti-hyperlipidemia, anti-osteoporotic, hepato-protective, immunomodulator, etc.…”

Section: Introductionmentioning

confidence: 99%

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. In this review, we have consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this review will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.

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“…The HCQ is the derivative of CQ, and is the first category drug which is working as a therapeutic agent against COVID-19 infection (Beura & Prabhakar 2020 ; Choudhary & Sharma 2020 ; Sinha & Balayla 2020 ). This drug has also been previously used for the treatment of rheumatoid arthritis and systemic lupus erythematosus (Adeoye et al., 2020 ; Sinha & Balayla 2020 ) and is a first line drug for malaria treatment (Azad et al., 2017 ; Bhardwaj et al., 2016 ; Roesch et al., 2020 ; Siddiqui et al., 2015 ). Effect of HCQ on viral replication goes beyond cytokines inhibition (Asai et al., 2020 ; Bhardwaj et al., 2015 ; Siddiqui, Bhardwaj, et al., 2020 ; Siddiqui, Adnan, et al., 2020 ; Sinha & Balayla 2020 ).…”

Section: Survey Methodologymentioning

confidence: 99%

Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2

Siddiqui

Jahan

Ashraf

et al. 2020

Journal of Biomolecular Structure and Dynamics

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The spread of new coronavirus infection starting December 2019 as novel SARS-CoV-2, identified as the causing agent of COVID-19, has affected all over the world and been declared as pandemic. Approximately, more than 8,807,398 confirmed cases of COVID-19 infection and 464,483 deaths have been reported globally till the end of 21 June 2020. Until now, there is no specific drug therapy or vaccine available for the treatment of COVID-19. However, some potential antimalarial drugs like hydroxychloroquine and azithromycin, antifilarial drug ivermectin and antiviral drugs have been tested by many research groups worldwide for their possible effect against the COVID-19. Hydroxychloroquine and ivermectin have been identified to act by creating the acidic condition in cells and inhibiting the importin (IMPa/b1) mediated viral import. There is a possibility that some other antimalarial drugs/antibiotics in combination with immunomodulators may help in combatting this pandemic disease. Therefore, this review focuses on the current use of various drugs as single agents (hydroxychloroquine, ivermectin, azithromycin, favipiravir, remdesivir, umifenovir, teicoplanin, nitazoxanide, doxycycline, and dexamethasone) or in combinations with immunomodulators additionally. Furthermore, possible mode of action, efficacy and current stage of clinical trials of various drug combinations against COVID-19 disease has also been discussed in detail.

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Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model

Cited by 14 publications

References 49 publications

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2

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