Repetitive transcranial magnetic stimulation; A cost-effective and beneficial treatment option for refractory focal seizures

VanHaerents, Stephen; Herman, Susan T.; Pang, Trudy; Pascual‐Leone, Álvaro; Shafi, Mouhsin M.

doi:10.1016/j.clinph.2014.12.004

Cited by 11 publications

(12 citation statements)

References 5 publications

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“…30,38 One patient who underwent 11 days of LF-rTMS achieved seizure freedom, reduced interictal discharges, and improved cognitive and motor skills. 39 One patient with repetitive prolonged focal motor seizures experienced solely a day of decreased seizures following 1 session of LF-rTMS. 30 rTMS has also been associated with seizure control in patients (both pediatric and adult) with EPC of various etiologies, including Rasmussen encephalitis, stroke, resected cortical vascular malformation, and focal cortical dysplasia.…”

Section: Ictal Rtms For Seizure Suppressionmentioning

confidence: 99%

“…The longest seizure-free intervals after treatment periods of >4 and 6 months reflect the duration of patient follow-up rather than the actual duration of the therapeutic effect of rTMS. 39,43 Time of application of rTMS has also varied among the published reports, with rTMS interventions ranging from 9 days into a patient's clinical presentation of SE to 15 years after presentation with EPC. None of the 17 patients experienced a worsening of seizures during or following rTMS treatment, and there were no reports of worsening EEG following rTMS.…”

Section: Ictal Rtms For Seizure Suppressionmentioning

confidence: 99%

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Review of Transcranial Magnetic Stimulation in Epilepsy

Tsuboyama

Kaye

Rotenberg

2020

Clinical Therapeutics

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Section: Ictal Rtms For Seizure Suppressionmentioning

confidence: 99%

Section: Ictal Rtms For Seizure Suppressionmentioning

confidence: 99%

Review of Transcranial Magnetic Stimulation in Epilepsy

Tsuboyama

Kaye

Rotenberg

2020

Clinical Therapeutics

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“…Antiepileptogenic effects of TMS was demonstrated in animal models (Akamatsu et al, 2001 ; Rotenberg et al, 2008 ; Lin et al, 2014 ; Yadollahpour et al, 2014 ) and human subjects (Menkes and Gruenthal, 2000 ; Kinoshita et al, 2005 ; Thordstein and Constantinescu, 2012 ; Liu et al, 2013 ; VanHaerents et al, 2015 ). Animal models of chemical induced seizure showed that specifically lower frequency stimulation (0.25–2 Hz range) has inhibitory effects on neuronal excitability.…”

Section: Interhemispheric Connectivity In Dbs Studiesmentioning

confidence: 99%

“…The strong correlation of interhemispheric connectivity was absent in a minimally conscious patient who had a brainstem lesion (Salvador et al, 2005 ). Also, subjects with various disease states such as Parkinson's disease (Spagnolo et al, 2013 ; Hohlefeld et al, 2014 ; Luo et al, 2015 ), epilepsy (Thordstein and Constantinescu, 2012 ; Liu et al, 2013 ; Lin et al, 2014 ; Yadollahpour et al, 2014 ; VanHaerents et al, 2015 ), stroke (Buchkremer-Ratzmann et al, 1996 ; Liepert et al, 2000 ; Takatsuru et al, 2009 ; Lim et al, 2014 ; Liu et al, 2015 ), and peripheral nerve injury (Pelled et al, 2007b , 2009 ; Pawela et al, 2010 ; Li et al, 2011 ; Han et al, 2013 ) showed alteration of interhemispheric interaction. Understanding the process of the disruption of interhemispheric interaction in brain injury and neurodegenerative disease may give important clues in optimizing rehabilitation and recovery from disease states.…”

Section: Introductionmentioning

confidence: 99%

Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases

Shin

Pelled

2017

Front. Neural Circuits

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Interhemispheric interaction has a major role in various neurobehavioral functions. Its disruption is a major contributor to the pathological changes in the setting of brain injury such as traumatic brain injury, peripheral nerve injury, and stroke, as well as neurodegenerative diseases. Because interhemispheric interaction has a crucial role in functional consequence in these neuropathological states, a review of noninvasive and state-of-the-art molecular based neuromodulation methods that focus on or have the potential to elucidate interhemispheric interaction have been performed. This yielded approximately 170 relevant articles on human subjects or animal models. There has been a recent surge of reports on noninvasive methods such as transcranial magnetic stimulation and transcranial direct current stimulation. Since these are noninvasive techniques with little to no side effects, their widespread use in clinical studies can be easily justified. The overview of novel neuromodulation methods and how they can be applied to study the role of interhemispheric communication in neural injury and neurodegenerative disease is provided. Additionally, the potential of each method in therapeutic use as well as investigating the pathophysiology of interhemispheric interaction in neurodegenerative diseases and brain injury is discussed. New technologies such as transcranial magnetic stimulation or transcranial direct current stimulation could have a great impact in understanding interhemispheric pathophysiology associated with acquired injury and neurodegenerative diseases, as well as designing improved rehabilitation therapies. Also, advances in molecular based neuromodulation techniques such as optogenetics and other chemical, thermal, and magnetic based methods provide new capabilities to stimulate or inhibit a specific brain location and a specific neuronal population.

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“…In humans, a recent systematic review of rTMS for refractory epilepsy has displayed the safety and tolerability with improvement in seizure frequency in the majority of studies [ 5 ]. Furthermore, recent arguments have surfaced supporting the cost effectiveness of rTMS for refractory epilepsy over standard failed antiepileptic drug (AED) based therapies [ 9 ]. Overall, recent evidence based guidelines support level C evidence for rTMS in the treatment of epilepsy [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Transcranial Magnetic Stimulation for Status Epilepticus

Zeiler

Matuszczak

Teitelbaum

et al. 2015

Epilepsy Research and Treatment

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Background. Our goal was to perform a systematic review on the use of repetitive transcranial magnetic stimulation (rTMS) in the treatment of status epilepticus (SE) and refractory status epilepticus (RSE). Methods. MEDLINE, BIOSIS, EMBASE, Global Health, Healthstar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform, clinicaltrials.gov (inception to August 2015), and gray literature were searched. The strength of evidence was adjudicated using Oxford and GRADE methodology. Results. We identified 11 original articles. Twenty-one patients were described, with 13 adult and 8 pediatric. All studies were retrospective. Seizure reduction/control with rTMS occurred in 15 of the 21 patients (71.4%), with 5 (23.8%) and 10 (47.6%) displaying partial and complete responses, respectively. Seizures recurred after rTMS in 73.3% of the patients who had initially responded. All studies were an Oxford level 4, GRADE D level of evidence. Conclusions. Oxford level 4, GRADE D evidence exists to suggest a potential impact on seizure control with the use of rTMS for FSE and FRSE, though durability of the therapy is short-lived. Routine use of rTMS in this context cannot be recommended at this time. Further prospective study of this intervention is warranted.

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Repetitive transcranial magnetic stimulation; A cost-effective and beneficial treatment option for refractory focal seizures

Cited by 11 publications

References 5 publications

Review of Transcranial Magnetic Stimulation in Epilepsy

Review of Transcranial Magnetic Stimulation in Epilepsy

Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases

Transcranial Magnetic Stimulation for Status Epilepticus

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