Repetitive Transcranial Magnetic Stimulation for Negative Symptoms of Schizophrenia

Lange, Jozarni J. Dlabac-de; Knegtering, Rikus; Alemán, André

doi:10.4088/jcp.08r04808yel

Cited by 134 publications

(74 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When only the studies with a stimulation frequency of 10 Hz included, the mean effect size increased to 0.63.Studies with at least 3 weeks duration had a larger mean effect size when compared to studies with shorter treatment duration. They concluded that the results of this meta-analysis warrant further study of rTMS as a potential treatment of negative symptoms of schizophrenia [15].…”

Section: Effect Of Rtms On Negative Symptomsmentioning

confidence: 91%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

View full text Add to dashboard Cite

Section: Effect Of Rtms On Negative Symptomsmentioning

confidence: 91%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

View full text Add to dashboard Cite

“…A meta-analysis review of nine clinical trials (n = 213 patients) showed that active rTMS could significantly improve the negative symptoms of schizophrenia compared with the sham rTMS. [57] However, the average weighted effect size was in the order of small-to-medium range (d = 0.43). [57] In a more recent, meta-analysis performed by Freitas et al on the efficacy of active rTMS versus control or placebo rTMS on negative and positive symptoms of schizophrenia they concluded moderate and significant effect sizes of active rTMS versus placebo stimulation.…”

Section: Schizophreniamentioning

confidence: 98%

“…[57] However, the average weighted effect size was in the order of small-to-medium range (d = 0.43). [57] In a more recent, meta-analysis performed by Freitas et al on the efficacy of active rTMS versus control or placebo rTMS on negative and positive symptoms of schizophrenia they concluded moderate and significant effect sizes of active rTMS versus placebo stimulation. [58] They reported significant and moderate effects of rTMS on negative and positive symptoms (d = 0.54 and d = 0.58, respectively).…”

Section: Schizophreniamentioning

confidence: 98%

Untitled

Rashidi

2017

AJP

View full text Add to dashboard Cite

Psychiatric disorders are the most common debilitating diseases worldwide. Repetitive transcranial magnetic stimulation (rTMS) has shown therapeutic outcomes in different neurophysiology and neuropsychiatric disorders. Despite controversial findings on the therapeutic outcomes of this technique in different psychiatric disorders, researchers emphasize on developing this technique as an alternative or adjunctive modality for these disorders. Depression, different hallucinations, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and substance abuse are the main disorders have shown good treatment response to rTMS. This study aims to comprehensively overview the applications and recent advances in rTMS applications in psychiatric disorders. The databases of PubMed (1985PubMed ( -2017, Web of Sciences (1985-2017, Embase (1985-2017), Cochrane Central Library (1985-2017), and Google Scholar (1985-2017 were searched using the keywords of repetitive transcranial magnetic stimulation OR rTMS AND psychiatric disorders AND treatment. The retrieved records were reviewed, and the relevant studies were selected for further review. Repeated sessions of low frequency (≤5 Hz) rTMS induce long-lasting neural inhibition or depotentiation, whereas high frequency (>5 Hz) induces long-lasting neural excitability or potentiation. Depending on the neural alteration induced by a disorder, low-or high-frequency rTMS is used for the treatment. The rTMS is approved as acute treatment for major depression. The other diseases with promising outcomes are different hallucinations, OCD, and PTSD. rTMS seems to be an alternative or adjunctive therapeutic modality in different psychiatric disorders. To reach efficient clinical application for each disorder, further randomized clinical trials, as well as preclinical studies, are needed.

show abstract

“…Typically, these studies involved the stimulation of the left DLPFC, as it has been done in depression, although one could argue that the right DLP-FC is also of relevance as it has been implicated in negative symptoms. Thus, future studies may also include the right DLPFC as a target of neurostimulation [47].…”

Section: Tms In Schizophreniamentioning

confidence: 99%

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

Andrade¹,

Mota²,

Ferreira³

et al. 2017

IJCNMH

View full text Add to dashboard Cite

The potential therapeutic value of electricity to treat neuropsychiatric disorders has been known for a long time. However, it is only recently that it has been successfully applied to these clinical conditions. Two of the most promising neuromodulation techniques are the deep brain stimulation (DBS) and the transcranial magnetic stimulation (TMS). DBS uses a high-frequency stimulation that causes a "reversible lesion" and is increasingly becoming an alternative for lesional surgery for its better balance between efficacy, tolerability and safety, and has consistently been shown to improve depressive and obsessive symptoms. TMS is a non-invasive and safe approach that has been approved for the treatment of major depressive disorder and for auditory-verbal hallucinations in schizophrenia and is being studied in several other psychiatric disorders, such as obsessive-compulsive disorder, eating disorders and negative symptoms of schizophrenia.In the current paper, we will review recent evidence of these two neuromodulation techniques, its main psychiatric indications and present two brief case reports to further illustrate its clinical applicability.

show abstract

Repetitive Transcranial Magnetic Stimulation for Negative Symptoms of Schizophrenia

Abstract: The results of this meta-analysis warrant further study of rTMS as a potential treatment of negative symptoms of schizophrenia.

Cited by 134 publications

References 0 publications

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Untitled

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

Contact Info

Product

Resources

About