Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex Reduces Nicotine Cue Craving

Li, Xingbao; Hartwell, Karen J.; Owens, Max M.; LeMatty, Todd; Borckardt, Jeffrey J.; Hanlon, Colleen A.; Brady, Kathleen T.; George, Mark S.

doi:10.1016/j.biopsych.2013.01.003

Cited by 183 publications

(159 citation statements)

References 63 publications

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“…As noted above, low frequency (≤1 Hz) rTMS inhibits neuronal firing in a localized area and is used to induce virtual lesions in order to examine a brain region’s role in different tasks (Chen et al, 1997; Iyer et al, 2003), while high frequency rTMS (≥5 Hz) tends to be excitatory and can cause an increase in neuronal depolarization under the stimulating coil (Haraldsson et al, 2004). Previous studies of rTMS over the DLPFC support the ability of rTMS to transiently reduce the level of craving in tobacco (Li et al, 2013), alcohol (Mishra et al, 2010), and cocaine (Camprodon et al, 2007) addicted patients. To the best of our knowledge, no study has used rTMS to modulate cue-induced craving in a MA dependent population.…”

Section: Introductionmentioning

confidence: 84%

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Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: A preliminary study

Malcolm

Huebner

et al. 2013

Drug and Alcohol Dependence

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Background Repetitive transcranial magnetic stimulation (rTMS) can temporarily interrupt or facilitate activity in a focal brain region. Several lines of evidence suggest that rTMS of the dorsolateral prefrontal cortex (DLPFC) can affect processes involved in drug addiction. We hypothesized that a single session of low-frequency rTMS of the left DLPFC would modulate cue-induced craving for methamphetamine (MA) when compared to a sham rTMS session. Methods In this single-blind, sham-controlled crossover study, 10 non-treatment seeking MA-dependent users and 8 healthy controls were randomized to receive 15 min of sham and real (1 Hz) DLPFC rTMS in two experimental sessions separated by 1 h. During each rTMS session, participants were exposed to blocks of neutral cues and MA-associated cues. Participants rated their craving after each cue block. Results In MA users, real rTMS over the left DLPFC increased self-reported craving as compared to sham stimulation (17.86 ± 1.46 vs. 24.85 ± 1.57, p = 0.001). rTMS had no effect on craving in healthy controls. One Hertz rTMS of the left DLPFC was safe and tolerable for all participants. Conclusions Low frequency rTMS of the left DLPFC transiently increased cue-induced craving in MA participants. These preliminary results suggest that 1 Hz rTMS of the left DLPFC may increase craving by inhibiting the prefrontal cortex or indirectly activating subcortical regions involved in craving.

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Section: Introductionmentioning

confidence: 84%

“…In nicotine dependent individuals, we previously reported that 15 min of excitatory, high frequency (10 Hz) rTMS of the left DLPFC significantly reduced cigarette cue-induced craving as compared to sham stimulation (Li et al, 2013). However, we did not compare high frequency rTMS with low frequency rTMS.…”

Section: Discussionmentioning

confidence: 99%

Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: A preliminary study

Malcolm

Huebner

et al. 2013

Drug and Alcohol Dependence

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“…Sobretudo, nesse estudo em nenhum momento se propôs investigar quais redes neurais estariam envolvidas no processo de vontade de fumar, muito pelo contrário, partindo de informações de trabalhos anteriores (Amiaz, Levy, Vainiger, Grunhaus, & Zangen, 2009;Eichhammer, 1899;Li et al, 2013), Dinur-Klein posicionou a bobina de forma a estimular o pré-frontal e insula. Além disso, a técnica de EMT é utilizada para a estimulação do cérebro e não para detecção de atividade cerebral, assim para se investigar as redes neurais envolvidas no processo de desejo por cigarro, como sugerido pela reportagem, seria necessário a utilização de outras técnicas, como por exemplo fMRI (sigla em inglês para imagem funcional por ressonância magnética), MEG (sigla em inglês para Magnetoencefalografia), EEG (sigla em inglês para Eletroencefalografia) ou PET (sigla em inglês para Tomografia por emissão de positrons).…”

Section: Isso é úTil Pois No Caso Da Depressão Há Um Aumento Da Atunclassified

Discussão sobre a divulgação da Estimulação Magnética Transcraniana na mídia brasileira

Peres¹

2016

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Recebido: 25mai15Aceito: 28jan16 Publicado: 31jan16Editado por Vítor Lopes-dos-Santos e revisado por Patrícia BadoResumo. A motivação para escrever esse artigo foi a existência da grande quantidade de reportagens com informações contraditórias, principalmente na área da saúde. Reportagens do tipo, cientistas afirmam que pimentas vermelhas fazem bem para o coração; cardiologistas advertem, pimenta pode ser um veneno para quem tem pressão alta; pimentas o segredo da longevidade, e daí por diante.No caso desses artigos eu não podia opinar mais do que o ceticismo científico e conhecimento leigo me permitiam. Entretanto me ocorreu procurar por artigos de divulgação sobre uma área que tenho experiência profissional, a Estimulação Magnética Transcraniana, também conhecida pela sigla EMT. Não foi surpresa que as reportagens publicadas apresentavam equívocos muito parecidos com àqueles das pimentas. Assim, com o intuito de apimentar um pouco a discussão sobre a divulgação científica, mais especificamente sobre a divulgação da EMT no Brasil, selecionei alguns textos que serão comentados a seguir. Gostaria de salientar que de maneira alguma esse artigo tem a intenção de denegrir a imagem das mídias de divulgação científica, muito pelo contrário, considero de suma importância o papel que as mesmas tem de levar para a população informações que dificilmente chegariam por meio das revistas especializadas. Palavras-chave. Estimulação Magnética Transcraniana; mídia brasileira; divulgação científica.Abstract. The motivation for writing this article was the existence of large number of reports with conflicting information, especially in health care. Reports like, scientists claim that red peppers are good for the heart; Cardiologists warn: pepper can be poison for those who have high blood pressure; peppers the secret of longevity, and so on. For those articles, I could not express an opinion more than scientific skepticism and lay knowledge allowed me. However, I had the idea to look for scientific reports about my professional area, transcranial magnetic stimulation, also known by the acronym TMS. It was no surprise that the reports about TMS had similar misunderstandings to those of peppers. Thus, in order to spice up the discussion about science communication, more specifically, reports of TMS in Brazil media, I selected some texts that are discussed below. I would like to emphasize that this article has not the intention to disparage the science communication media, actually I consider very important the role that they have, bringing to the lay public information that hardly would get them by the specialized magazines.

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“…rTMS over the left DLPFC can also alleviate symptoms in other conditions such as substance use disorders [3] and posttraumatic stress disorders [4] which are also importantly related to HPA axis dysfunction [5]. It would thus be interesting to investigate whether rTMS over the left DLPFC modulates the HPA axis in these conditions.…”

Section: Modulation Of Brain Activitymentioning

confidence: 99%

Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

Fecteau¹

2015

Brain Stimulation

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Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex Reduces Nicotine Cue Craving

Cited by 183 publications

References 63 publications

Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: A preliminary study

Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: A preliminary study

Discussão sobre a divulgação da Estimulação Magnética Transcraniana na mídia brasileira

Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

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