Repetitive transcranial magnetic stimulation (rTMS) modulates time-varying electroencephalography (EEG) network in primary insomnia patients: a TMS-EEG study

Song, Penghui; Hua, Lin; Li, Siran; Wang, Li; Liu, Jianghong; Li, Ning; Wang, Yuping

doi:10.1016/j.sleep.2019.01.007

Cited by 46 publications

(39 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In one study the frequency of EEG abnormalities decreased after rTMS treatment while PSG parameters of sleep efficiency and total sleep time improved significantly (Sánchez-Escandón et al 2014). In the other study, EEG recordings of insomnia patients showed over-active or under-active brain regions as compared to healthy controls (Song et al 2019). After rTMS treatment, EEG data of these areas showed moderate improvement in reversing back to normal activity level.…”

Section: Biological Measurement Outcomesmentioning

confidence: 84%

See 1 more Smart Citation

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulatory technique approved by the US Food and Drug Administration for use in treatment-resistant major depressive disorder. It works by generating localized magnetic fields that create depolarizing electrical currents in neurons a few centimeters below the scalp. This localized effect is believed to stimulate neural plasticity, activate compensatory processes, and influence cortical excitability. Additionally, rTMS has been used in a variety of clinical trials for neurological and psychiatric conditions such as anxiety, post-traumatic stress disorder and epilepsy. Beneficial effects in sleep parameters have been documented in these trials, as well as in major depressive disorder, and have led to an interest in using rTMS in the field of sleep medicine for specific disorders such as insomnia, hypersomnia, and restless legs syndrome. It is unknown whether rTMS has intrinsically beneficial properties when applied to primary sleep disorders, or if it only acts on sleep through mood disorders. This narrative review sought to examine available literature regarding the application of rTMS for sleep disorder to identify knowledge gaps and inform future study design. The literature in this area remains scarce, with few randomized clinical trials on rTMS and insomnia. Available studies have found mixed results, with some studies reporting subjective sleep improvement while objective improvement is less consistent. Due to the heterogeneity of results and the variations in rTMS protocols, no definitive conclusions have been reached, signaling the need for further research.

show abstract

Section: Biological Measurement Outcomesmentioning

confidence: 84%

“…In combination with PSG and questionnaires, two studies used electroencephalogram (EEG) to examine abnormalities present in patients suffering from chronic insomnia (Sánchez-Escandón et al 2014;Song et al 2019). EEG recordings were done before and after rTMS sessions for comparison.…”

Section: Biological Measurement Outcomesmentioning

confidence: 99%

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

View full text Add to dashboard Cite

show abstract

“…Low-frequency repetitive TMS treatment has also been demonstrated to have an antiepileptic effect on patients with refractory focal seizures [ 57 , 58 ]. TMS also has been used to treat sleep disorders, including OSA, sleep bruxism, RLS, narcolepsy, and primary insomnia, but the stimulating targets at brain regions are different based on their pathophysiological brain networks [ 59 - 61 ]. The therapeutic use of tDCS has been studied regarding pain, epilepsy, depression, movement disorders, etc .…”

Section: Non-pharmacological Therapiesmentioning

confidence: 99%

The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy

Peng

Ding

Wang

2021

View full text Add to dashboard Cite

Background: There is a complex and interactive relationship between sleep and epilepsy. Sleep disorders are common in patients with epilepsy, and methods for managing sleep disorders in patients with epilepsy are limited. Objective: This review is to address the relationships among sleep, sleep disorders, and epilepsy, focusing on the managements for sleep disorders in epilepsy, including some complementary and alternative therapies. Methods: The terms related to “sleep” and “epilepsy” were searched in “Pubmed” and “Cochrane Library”. Results: Sleep stages differently affects both of seizures and interictal epileptiform discharges. Seizures disrupt sleep architectures greatly, especially when arising from sleep in the night. Insomnia and obstructive sleep apnea (OSA) are the most frequent types of comorbid sleep disorders in patients with epilepsy. Pharmacological agents with both anti-convulsant and sedative effects are the priorities for comorbid sleep disorders in epilepsy. Continuous positive airway pressure (CPAP) therapy is the most effective non-pharmacological method to improve OSA and reduce seizures. Complementary and alternative therapies such as Chinese traditional medicine, cognitive behavioral therapy, meditation, yoga, neurofeedback, and acupuncture may have benefits on reducing seizures and improving sleep quality simultaneously by alleviating stress and seizure triggers, however, evidence-based therapies are still in deficiency. Conclusion: Managements for sleep disorders in patients with epilepsy are challenging. Large sample randomized controlled trials are in demand in the future.

show abstract

“…Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication resistant depression (Boes et al, 2018;Trapp et al, 2020). Numerous studies have investigated the neurophysiological, neuroanatomical, and functional connectivity effects relative to rTMS (Bailey et al, 2019;Ge et al, 2020;Keuper et al, 2018;Noda et al, 2017;Song et al, 2019;Wu et al, 2020). The typical target for rTMS is the left dorsolateral prefrontal cortex (DLPFC) with effects seen in cortical thickness in rostral anterior cingulate cortex (rACC) (Boes et al, 2018;Trapp et al, 2020).…”

Section: Jeff Tarrantmentioning

confidence: 99%

Proceedings of the 2021 ISNR Annual Conference (Virtual): Keynote and Plenary Presentations

Research¹

2021

View full text Add to dashboard Cite

show abstract

Repetitive transcranial magnetic stimulation (rTMS) modulates time-varying electroencephalography (EEG) network in primary insomnia patients: a TMS-EEG study

Cited by 46 publications

References 50 publications

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy

Proceedings of the 2021 ISNR Annual Conference (Virtual): Keynote and Plenary Presentations

Contact Info

Product

Resources

About