Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease

Helmich, Rick C.; Siebner, Hartwig R.; Bakker, M.; Münchau, Alexander; Bloem, Bastiaan R.

doi:10.1016/j.jns.2006.05.009

Cited by 55 publications

(42 citation statements)

References 71 publications

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“…The minimal number of TMS pulses during a TMS session has varied from 30 to 2,000 pulses/per session range with frequency from once per week over 8 weeks to twice a day over 10 days in different reports (Daskalakis et al 2002). As it was concluded in a review (Helmich et al 2006) rTMS with less than 100 pulses/per session and less than twice per week are not very promising in terms of therapeutic efficacy.…”

Section: Tms Proceduresmentioning

confidence: 99%

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

Sokhadze

El-Baz

Baruth

et al. 2008

J Autism Dev Disord

132

136

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Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnosed) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism.

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Section: Tms Proceduresmentioning

confidence: 99%

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

Sokhadze

El-Baz

Baruth

et al. 2008

J Autism Dev Disord

132

136

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“…However, the cortical area that is influenced by this technique is quite large (on the order of centimeters) and is non-specific (stimulation varies depending on the coil orientation) due to the inductive nature of magnetic stimulation [7] . Subsequently, the large stimulation focus may cause excitation to spread to neighboring cortical structures and could possibly produce serious side effects such as seizures [8] . In addition, since magnetic field strength decreases drastically over distance, deep brain structures cannot be targeted.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Focused Ultrasound to the Thalamus Is Associated with Reduced Extracellular GABA Levels in Rats

Yang¹,

Kim²,

Lee³

et al. 2012

Neuropsychobiology

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Objective: Transcranial focused ultrasound (FUS), with its ability to non-invasively modulate the excitability of region-specific brain areas, is gaining attention as a potential neurotherapeutic modality. The aim of this study was to examine whether or not FUS administered to the brain could alter the extracellular levels of glutamate and γ-aminobutyric acid (GABA), which are representative excitatory and inhibitory amino acid neurotransmitters, respectively. Methods: FUS, delivered in the form of a train of pulses, was applied to the thalamus of Sprague-Dawley rats transcranially. Glutamate and GABA were directly sampled from the frontal lobe of the rat brain via a direct microdialysis technique before, during, and after the sonication. The dialysate concentrations were determined by high-performance liquid chromatography. Results: The individual levels of the neurotransmitters sampled were normalized to the baseline level for each rat. In terms of the changes in extracellular glutamate levels, there was no difference between the FUS-treated group and the unsonicated control group. However, extracellular GABA levels started to decrease upon sonication and remained reduced (approximately 20% below baseline; repeated-measures ANOVA, p < 0.05, adjusted for multiple comparisons) compared to the control group. Conclusion: The ability to modulate region-specific brain activity, along with the present evidence of the ability to modulate neurotransmission, demonstrates the potential utility of FUS as a completely new non-invasive therapeutic modality.

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“…In particular, 5-Hz rTMS may improve QoL and motor performances, in addition to the deterioration rate reduction that has been reported with other rTMS protocols [11,12]. The review of therapeutic rTMS studies in Parkinson's disease [27] and depression [28] indicate beneficial effects to different rTMS protocols in these two conditions. Future double-blind therapeutic trials of rTMS in ALS should explore the effect of different rTMS protocols for optimizing the efficacy of this type of treatment.…”

Section: Discussionmentioning

confidence: 79%

The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis

Zanette

Forgione

Manganotti

et al. 2008

Journal of the Neurological Sciences

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Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease

Cited by 55 publications

References 71 publications

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

Transcranial Focused Ultrasound to the Thalamus Is Associated with Reduced Extracellular GABA Levels in Rats

The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis

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