The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis

Zanette, Giampietro; Forgione, Antonio; Manganotti, Paolo; Fiaschi, Antonio; Tamburin, Stefano

doi:10.1016/j.jns.2008.01.011

Cited by 42 publications

(24 citation statements)

References 28 publications

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“…Two studies 66 67 compared low-frequency (1 Hz) and high-frequency (20 Hz) rTMS. Zanette et al 68 used an intermediate frequency of 5 Hz with the stated rationale of combining the effects of reduced cortical excitability with low-frequency rTMS and BDNF release at high frequencies.…”

Section: Repetitive Tmsmentioning

confidence: 99%

Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience

Edmond¹,

Stagg²,

Turner³

2019

J Neurol Neurosurg Psychiatry

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The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.

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Section: Repetitive Tmsmentioning

confidence: 99%

Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience

Edmond¹,

Stagg²,

Turner³

2019

J Neurol Neurosurg Psychiatry

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“…21 Another report indicated that 5 Hz rTMS may improve motor function and quality of life in ALS. 22…”

Section: Repetitive Transcranial Magnetic Stimulationmentioning

confidence: 99%

Clinical neurorestorative progress in amyotrophic lateral sclerosis

Chen¹,

Huang²,

Hao³

et al. 2015

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Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by progressive paralysis and motor neuron death. In addition to symptomatic managements such as ventilation and nutritional support, neurorestorative therapies have demonstrated anti-neurodegenerative potential and may improve quality of life for patients. Currently, clinical neurorestorative strategies include pharmacological management (granulocyte colony stimulating factor), neuromodulatory intervention (repetitive transcranial magnetic and cortical stimulation), cell transplantation (bone marrow stromal cells, olfactory ensheathing cells, granulocyte colony stimulating factor-mobilized peripheral blood stromal cells, hematopoietic stem and progenitor cells, neural stem/progenitor cells, CD133 + cells and CD34 + cells), bioengineering and tissue engineering therapy, and combined neurorehabilitative treatment. In this review, we describe the latest progress in clinical neurorestorative management of amyotrophic lateral sclerosis and discuss the underlying evidence base.

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“…127 The neural circuitry underlying ALS can be noninvasively probed using TMS, [128][129][130][131][132][133][134][135][136][137][138][139][140][141] and a number of studies have investigated the potential of rTMS as a treatment for ALS, mainly by slowing the progression of the disease. [142][143][144][145][146][147][148][149]…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

“…There have been a number of studies investigating the effects of rTMS application over M1 in an attempt to treat the motor symptoms of ALS. [142][143][144][145][146][147][148][149] It is difficult to form generalized conclusions from this body of work owing to the heterogeneity of the rTMS employed; these protocols differed in terms of the frequency, duration, and dose of stimulation delivered. 149 Some studies show improvements in symptoms, behavior, and normalization of cortical excitability due to rTMS.…”

Section: Treatmentmentioning

confidence: 99%

Use of transcranial magnetic stimulation in the treatment of selected movement disorders

Brown

Neva

Ledwell

et al. 2014

DNND

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Transcranial magnetic stimulation (TMS) is a valuable technique for assessing the underlying neurophysiology associated with various neuropathologies, and is a unique tool for establishing potential neural mechanisms responsible for disease progression. Recently, repetitive TMS (rTMS) has been advanced as a potential therapeutic technique to treat selected neurologic disorders. In healthy individuals, rTMS can induce changes in cortical excitability. Therefore, targeting specific cortical areas affected by movement disorders theoretically may alter symptomology. This review discusses the evidence for the efficacy of rTMS in Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. It is hoped that gaining a more thorough understanding of the timing and parameters of rTMS in individuals with neurodegenerative disorders may advance both clinical care and research into the most effective uses of this technology.

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The effect of repetitive transcranial magnetic stimulation on motor performance, fatigue and quality of life in amyotrophic lateral sclerosis

Cited by 42 publications

References 28 publications

Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience

Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience

Clinical neurorestorative progress in amyotrophic lateral sclerosis

Use of transcranial magnetic stimulation in the treatment of selected movement disorders

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