Replacing Pumps with Light Controlled Insulin Delivery

Abstract

Purpose of Review-The aim of this review is to summarize the development of the photoactivated depot (PAD) approach for the minimally invasive and continuously variable delivery of insulin. Recent Findings-Using an insulin PAD, we have demonstrated that we can release native, bioactive insulin into diabetic animals in response to light signals from a small external LED light source. We have further shown that this released insulin retains bioactivity and reduces blood glucose. In addition, we have designed and constructed second generation materials that have high insulin densities, with the potential for multiple day delivery. Summary-The PAD approach for insulin therapy holds promise for addressing the pressing need for continuously variable delivery methods that do not rely on pumps, and their myriad associated problems.

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management

“…The novel idea of light-activated insulin is revolutionary for controlling blood glucose levels, providing a fresh approach to treating diabetes [ 11 , 112 ]. This approach entails producing small-molecule biosimilars or insulin derivatives that are both safe and exhibit reduced side effects [ 112 ]. These compounds may be triggered by light exposure [ 11 , 112 ].…”

“…This approach entails producing small-molecule biosimilars or insulin derivatives that are both safe and exhibit reduced side effects [ 112 ]. These compounds may be triggered by light exposure [ 11 , 112 ]. Interdisciplinary cooperation and improved scientific methodologies are necessary to develop insulin derivatives.…”