2003
DOI: 10.1128/jvi.77.15.8394-8407.2003
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Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L

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Cited by 62 publications
(61 citation statements)
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References 71 publications
(87 reference statements)
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“…When analysing this response, we noticed that MVA-DE3L had lost its ability to grow in CEF, and that this failure correlated with the induction of apoptosis in CEF cells. 15 To find out whether this apoptotic response was confined to CEF, we first infected HeLa human epithelial cells with MVA or MVA-DE3L. Cells infected with MVA did not undergo apoptosis and showed a strong resistance to apoptosis induced by treatment with staurosporine ( Figure 1a).…”
Section: Apoptosis Induction By Mva-de3lmentioning
confidence: 99%
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“…When analysing this response, we noticed that MVA-DE3L had lost its ability to grow in CEF, and that this failure correlated with the induction of apoptosis in CEF cells. 15 To find out whether this apoptotic response was confined to CEF, we first infected HeLa human epithelial cells with MVA or MVA-DE3L. Cells infected with MVA did not undergo apoptosis and showed a strong resistance to apoptosis induced by treatment with staurosporine ( Figure 1a).…”
Section: Apoptosis Induction By Mva-de3lmentioning
confidence: 99%
“…Vaccinia virus MVA (cloned isolate F6 at 582nd CEF passage), 42 and MVA-DE3L 15 were routinely propagated and titrated by vaccinia virusspecific immunostaining on BHK-21 cells to determine the numbers of infectious units (IU) per milliliter. Vaccinia virus MVA (cloned isolate II new ) 42,43 and MVA-DF1L were amplified and titrated on CEF.…”
Section: Cells and Virusesmentioning
confidence: 99%
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“…An MVA E3L deletion mutant (MVA-⌬E3L) was found to be unable to replicate in CEF, the cell culture used for serial passage in MVA attenuation, but to possess full replicative capacity in mammalian BHK-21 cells (44). This vaccinia virus host range phenotype in CEF was associated with deficient viral DNA and protein synthesis, induction of apoptosis, and enhanced production of chicken IFN-␣/␤ (44).…”
mentioning
confidence: 99%