Replication of swine and human influenza viruses in juvenile and layer turkey hens

Ali, Ahmed; Yassine, Hadi M.; Awe, Olusegun O.; Ibrahim, Mahmoud; Saif, Y. M.; Lee, Chang-Won

doi:10.1016/j.vetmic.2012.12.018

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…At 10 DPI all birds were bled to determine the hemagglutination inhibition (HI) titers [27]. Swab samples were processed as previously described [28]. Briefly, swab samples were vortexed and then centrifuged at 2000 rpm for 10 min at 4 • C to pellet the debris.…”

Section: Vaccination and Challenge Of Birdsmentioning

confidence: 99%

Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens

Elaish

Kang

Xia

et al. 2015

Vaccine

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Section: Vaccination and Challenge Of Birdsmentioning

confidence: 99%

Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens

Elaish

Kang

Xia

et al. 2015

Vaccine

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“…Outbreaks of pH1N1 infections in turkey breeder flocks were reported in several countries. However, although virus shedding and/or seroconversion could be detected in the experimentally inoculated turkeys, transmission between turkeys was not observed 29 30 31 32 . Different genetic characteristics between strains isolated from turkeys and humans might contribute to this inconsistency, and there are still no infection experiments in turkeys using pH1N1 clinically isolated from turkeys.…”

Section: Discussionmentioning

confidence: 89%

“…Turkeys are susceptible to a wide variety of influenza A viruses, including those from wild birds, swine and humans 15 28 29 . Therefore, turkeys are also a potential “mixing vessel” for influenza viruses.…”

Section: Discussionmentioning

confidence: 99%

The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses

Sun

Kong

Liu

et al. 2015

Sci Rep

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Outbreaks of pandemic H1N1 2009 (pH1N1) in turkeys have been reported in several countries. Co-infection of pH1N1 and avian H9N2 influenza viruses in turkeys provide the opportunity for their reassortment, and novel reassortant viruses might further be transmitted to other avian species. However, virulence and transmission of those reassortant viruses in poultry remain unclear. In the present study, we generated 16 single-gene reassortant influenza viruses including eight reassortants on the pH1N1 background by individual replacement with a corresponding gene segment from H9N2 and eight reassortants on the H9N2 background replaced individually with corresponding gene from pH1N1, and characterized reassortants viruses in turkeys and chickens. We found that the pH1N1 virus dramatically increased its infectivity and transmissibility in turkeys and chickens after introducing any gene (except for PB2) from H9N2 virus, and H9N2 virus acquired single gene (except for HA) of pH1N1 almost did not influence its replication and transmission in turkeys and chickens. Additionally, 13 reassortant viruses transmitted from turkeys to chickens. Our results indicate that turkeys and chickens are susceptible to pH1N1-H9N2 reassortant viruses, and mixing breeding of different avian species would facilitate the transmission of these reassortant viruses.

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“…In all cases, the clinical presentation was an acute and marked reduction in egg production that was often associated with activities of artificial insemination crews or infected poultry workers. Turkeys can be infected with mammalian origin influenza viruses that have an α‐2,6 sialic acid‐binding preference (Ali et al., ). The ability of swine origin classical H1N1 (Mohan et al., ) and triple reassortant H3N2 (Choi et al., ) viruses to infect turkeys has been recognized for some time.…”

Section: Introductionmentioning

confidence: 99%

Reoccurrence of Suspected Human-to-Turkey Transmission of H1N1 Pandemic 2009 Virus in Turkey Breeder Flocks in Ontario and Manitoba, 2016

Berhane

Ojkić

Pople

et al. 2016

Transbound Emerg Dis

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Summary Soon after the emergence of 2009 pandemic H1N1, the first outbreaks in breeder turkey operations were reported that implicated human‐to‐turkey transmission. In the spring of 2016, the reoccurrence of 2009 pandemic H1N1 lineage viruses infecting breeder turkey flocks in Ontario and Manitoba, Canada, also implicated human‐to‐turkey transmission. In addition to raising concerns over biosecurity and vaccine failures, these cases once again raise the issue of whether turkeys have the potential to act as a bridge species to generate novel influenza A virus reassortants with public health implications.

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Replication of swine and human influenza viruses in juvenile and layer turkey hens

Cited by 12 publications

References 39 publications

Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens

Immunogenicity and protective efficacy of the norovirus P particle-M2e chimeric vaccine in chickens

The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses

Reoccurrence of Suspected Human-to-Turkey Transmission of H1N1 Pandemic 2009 Virus in Turkey Breeder Flocks in Ontario and Manitoba, 2016

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