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Wilkinson, K. G.

doi:10.1017/s0001924000062370

Cited by 2 publications

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“…[7][8][9] Earlier studies report antiplasmodial activity in vitro against P. yoelii and P. falciparum for acridone derivatives, 10,11 and the antimalarial activity of several dihydroacridinediones is currently under investigation. 12,13 To obtain preliminary information of a possible mode of action and prediction of cross resistance with chloroquine (CQ), the four isolated alkaloids were assessed for antiplasmodial activity on a Nigerian chloroquine-sensitive (CS) strain 14 and the chloroquine-resistant (CR) strain FcM29. As reported in Table 1, all the test compounds showed good antiplasmodial activity.…”

Section: Swinglea Glutinosamentioning

confidence: 99%

Bioactive Acridone Alkaloids from Swinglea glutinosa

Weniger

Valentin

et al. 2001

J. Nat. Prod.

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A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

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Section: Swinglea Glutinosamentioning

confidence: 99%

Bioactive Acridone Alkaloids from Swinglea glutinosa

Weniger

Valentin

et al. 2001

J. Nat. Prod.

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“…In several experiments it has been shown that noise has the same effect as an incentive, acting as an arousal-increasing agent when arousal is at a low level, either after sleep deprivation (Wilkinson, 1963) or after alcohol intake (Colquhoun and Edwards, 1975). But even in normally aroused states, activation by sound has been found.…”

Section: Introductionmentioning

confidence: 99%

Selective Noise Disturbance of the Information Input in Short-Term Memory

Salamé¹,

Wittersheim²

1978

Quarterly Journal of Experimental Psychology

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The present experiment was designed in order to investigate the effects of noise produced intermittently during the input stage of serially displayed visual materials (6-digit lists). These materials were to be memorized and subsequently reproduced on a specially designed keyboard. The four experimental conditions were the following :(11 quiet (Q);(2) noise uninterrupted during the presentation of each list (CN); (3) noise emitted simultaneously with each list element (500 ms) (ND); (4) noise emitted in the interval (140 ms) between each element (NA). Record was takenof the errors and omissions, of key response initiating timesand of hand movement times. As an additional variable, subjects were required to estimate the annoyance induced by each of the four conditions. All noise conditions yielded more errors and omissions than the Q-condition, with the highest rates occurring in the two conditions where noise was superimposed on the digits. Close analysis of the errors showed that the primacy end of the lists was the most affected by noise, whereas keying speed for correct reproductions remained relatively unaffected.On the other hand, when the speed variable was split into a decision and a motor component, it turned out that the more a condition was judged as annoying, the more the time for response decision was delayed, while the reverse occurred for keying movement times. The latter effect could possibly be ascribed to arousal induced by the three noise conditions. It is argued that noise is liable to affect differently the various components of a task performance, either directly by interference with the intake of pertinent information, or indirectly through induced annoyance or through noise modulated arousal.

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Cited by 2 publications

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Bioactive Acridone Alkaloids from Swinglea glutinosa

Bioactive Acridone Alkaloids from Swinglea glutinosa

Selective Noise Disturbance of the Information Input in Short-Term Memory

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