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Pohjavuori, Emma; Viljanen, Mirva; Korpela, Riitta; Kuitunen, Mikael; Tiittanen, Minna; Vaarala, Outi; Savilahti, Erkki

doi:10.1016/j.jaci.2004.09.031

Cited by 2 publications

(1 citation statement)

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“…A double-blind clinical study in children who were allergic to cow's milk also showed that the administration of L. rhamnosus GG for four weeks increased IFNproduction in PBMCs after stimulation with anti-CD3/anti-CD28. At the same time, it suppressed secretion of IL-4, normally produced in large quantities after stimulation of the CD4+ T cells in allergic children (Pohjavuori et al, 2004). This Th2 response inhibition by L. rhamnosus GG can be explained by the presence of bacterial enzymes, which degrade casein in order to generate metabolites that influence the Th1/Th2 balance.…”

Section: Immunomodulatory Effects Of Probiotics In the Intestinal Tract 45mentioning

confidence: 97%

Immunomodulatory Effects of Probiotics in the Intestinal Tract

Delcenserie

Martel²,

Lamoureux³

et al. 2008

Current Issues in Molecular Biology

105

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The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the initiating event in immunomodulation and merits particular attention. The effects of probiotic is strain dependent and for each new probiotic strain, profiles of cytokines secreted by lymphocytes, enterocytes or dendritic cells that come in contact with the strain should be systematically established. To evaluate the effects of probiotics on the immune system, models that mimic the mucosa, and thus the physiological reality, should be preferred whenever it is possible. Then, the in vitro observed effects should be backed up by properly conducted randomized double bind clinical studies. More detailed studies are needed to determine the precise action mode of probiotics on both mucosal and systemic immunity.

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Section: Immunomodulatory Effects Of Probiotics In the Intestinal Tract 45mentioning

confidence: 97%