Reply by author to discussion by Dr. S. K. Singh

Verma, Saurabh

doi:10.1190/1.1486795

Cited by 26 publications

(41 citation statements)

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“…It has been experienced by us 18 and Professor Hogarth's coworkers 19 that transition metal dithiocarbamate complexes with functionalised backbones are easy to synthesize but their crystallization can be more problematic. L and 1-5 were characterized by microanalysis, standard spectroscopy viz.…”

Section: -Chloro-3-{2-(piperazinyl)ethyl}-amino-14-naphthoquinone (L)mentioning

confidence: 99%

“…A new band clearly seen at 389 nm in the electronic absorption spectrum of nickel complex 3, probably arises due to intra ligand charge transfer transitions associated with N-C]S group of coordinated dithiocarbamate ligands. 18,27 The Zn(II) complex 5 is of white colour and presents a featureless electronic spectrum. Further, cobalt(III) complex 2 exhibits a weak absorption band at $649 nm, which is consistent with the absorption behavior of [Co{k 2 S,S-S 2 C-piperazine-C 2 H 4 N]C(Ph)} 3 ] 18 and other cobalt(III) complexes.…”

Section: Electronic Absorption Spectral and Magnetic Moment Studiesmentioning

confidence: 99%

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Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]

Verma

Singh

2015

RSC Adv.

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A novel multifunctional ligand precursor 2-chloro-3-{2-(piperazinyl)ethyl}-amino-1,4-naphthoquinone (L) was synthesized by chemo-selective reaction of 2,3-dichloro-1,4-naphthoquinone and 2-(piperazin-1-yl)ethanamine and characterized, prior to use. A series of mononuclear transition metal dithiocarbamate complexes [M{k 2 S,S-S 2 C-piperazine-C 2 H 4 N(H)ClNQ} n ] {M ¼ Mn(III) 1, Co(III) 2, Ni(II) 3, Cu(II) 4, Zn(II) 5; ClNQ ¼ 2-chloro-1,4-naphthoquinone; n ¼ 3 for 1-2 and n ¼ 2 for 3-5} bearing pendant 2-chloro-3-amino-1,4-naphthoquinone groups were efficiently synthesized through a selfassembly process involving L, CS 2 and corresponding metal acetates. 1-5 were characterized by microanalysis and standard spectroscopic methods such as ESI-MS, IR, 1 H and 13 C NMR and UV-visible absorption spectroscopy. Significantly, all compounds exhibit medium to very strong fluorescence emission bands in the visible region with concomitant Stokes shifts of z280 nm upon excitation at their respective l max values. Thermal stability of complexes 1-5 has been investigated by thermogravimetric analysis. Cyclic voltammetric study clearly reveals that L and 1-5 are electro active with respect to the dominant redox-active naphthoquinone moiety. Further, L and 1-5 were tested against six important pathogen microorganisms viz. S. aureus, B. subtilis, E. coli, P. aeruginosa, C. albicans and A. niger by using the Broth dilution method. A broad spectrum of the strongest antimicrobial activity was determined for the copper(II) complex 4 and L. The enhanced antibacterial activity of L and copper(II) complex 4 against S. aureus apparently reveals them to be a superior antibacterial agent than the reference drug ciprofloxacin.

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Section: -Chloro-3-{2-(piperazinyl)ethyl}-amino-14-naphthoquinone (L)mentioning

confidence: 99%

Section: Electronic Absorption Spectral and Magnetic Moment Studiesmentioning

confidence: 99%

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]

Verma

Singh

2015

RSC Adv.

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“…The peaks corresponding to the ligand functionalities in the 1 H NMR spectra of the complexes (Supporting Information) appear very well in the expected range. Distinctly, in the 13 C NMR spectra, all the diamagnetic complexes showed a single distinct downfield resonance at δ 206–207 ppm associated with the N–CS 2 unit ,. (Figure S12, S14, S16, S18, S20, S22).…”

Section: Resultsmentioning

confidence: 96%

Derivatives of 4, 4’‐Oxydianiline Show Distinct In Vitro Cytotoxicity, Apoptosis Induction, and Selectivity against HepG2 Cancer Cells

et al. 2017

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Gathering of number of pharmacophore on a single molecular platform evidently lead to improved therapeutic efficiencies and reduced side effects of conventional chemotherapy drugs. Three diamino precursors 4,4’‐bis(2‐(alkylamino)acetamido)diphenylether (L1‐L3) was selected to derive new series of metallomacrocyclic dithiocarbamate complexes [M2‐μ2‐bis‐{(κ2S,S‐S2CN(R)CH2CONHC6H4)2O}] {R=Cy, M=NiII1a, CuII 1 b, ZnII1c; R=iPr, M=NiII2a, CuII 2 b, ZnII2c; R=nBu, M=NiII3a, CuII 3 b, ZnII3c}. These were characterized by standard spectroscopic and thermogravimetric methods. MTT assay was carried out on these compounds to explore their in vitro cytotoxicity against HepG2 (hepatoma) cell line. The diamino derivatives (L1‐L3) in their metal‐free form and metallomacrocyclic complexes, 1 a, 1 c, 2 a, 2 b, 2 c, 3 a, 3 b and 3 c exhibit improved cytotoxicity than Cisplatin and selectivity against HepG2 over normal cells. Remarkably, complexes 2 c (3.55 ± 0.06 μM) and 3 c (2.19 ± 0.04 μM) demonstrate 21 folds to 34 folds better cytotoxic activity whereas L3 (5.49 ± 0.04 μM), 1 a (7.27 ± 0.16 μM) and 3 a (4.42 ± 0.06 μM) showed more than 10 fold better cytotoxic activity against HepG2 cell line as compared to the reference drug Cisplatin. Morphological evidences like shrinking of cells indicates the induction of apoptosis as part of the mechanism of action of these compounds which is further supported by the distinct staining of the cells by acridine orange/ethidium bromide (AO/EB).

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“…In our study, chitogallates also have antioxidants activities as well as GA itself as shown in Figure . Many reports noted that natural materials having antioxidant power are able to suppress MMP activities in cancer cells and, then, reduce invasion, metastasis and angiogenesis of tumor . Antioxidants potential is related to suppress MMP activities and inhibition of MMP has an important to inhibit invasion/metastasis of cancer cells .…”

Section: Discussionmentioning

confidence: 99%

Antimetastatic Activity of Gallic Acid‐conjugated Chitosan against Pulmonary Metastasis of Colon Carcinoma Cells

Lee

Choi

Kim

et al. 2017

Bulletin Korean Chem Soc

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We synthesized gallic acid (GA)‐conjugated chitosan (abbreviated as chitogallate) to study its antitumor activity against CT26 mouse colorectal carcinoma cells. GA was conjugated with chitosan by aid of water‐soluble carbodiimide. Chitogallate nanoparticles were prepared by dialysis method, and these nanoparticles have spherical shapes with sizes ranged about 70–250 nm. Chitogallate nanoparticles have superior antioxidants activities as well as GA itself. At cytotoxicity study, GA showed dose‐dependent cytotoxicities against CCD986sk cells and CT26 cells while chitogallate nanoparticles were not significantly affected to the viability of cells. In Matrigel invasion assay, chitogallate nanoparticles have superior anti‐invasive capacity against cancer cells as well as GA itself, i.e., invasiveness of CT26 cells was decreased according to GA contents in chitogallate nanoparticles. Furthermore, gelatin zymography also showed that chitogallate nanoparticles having higher substitution degree of GA decreased matrix metalloproteinase‐2 activity. Chitogallate nanoparticles efficiently inhibited pulmonary metastasis of CT26 cells in animal pulmonary metastasis model. We prepared chitogallate nanoparticles for application as an anti‐invasive agent. Chitogallate nanoparticles were less toxic than GA itself and have superior anti‐invasive/antimetastatic activity. We suggest that chitogallate nanoparticles are promising candidate for inhibition of tumor invasion/metastasis.

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Reply by author to discussion by Dr. S. K. Singh

Cited by 26 publications

References 0 publications

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]

Derivatives of 4, 4’‐Oxydianiline Show Distinct In Vitro Cytotoxicity, Apoptosis Induction, and Selectivity against HepG2 Cancer Cells

Antimetastatic Activity of Gallic Acid‐conjugated Chitosan against Pulmonary Metastasis of Colon Carcinoma Cells

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Reply by author to discussion by Dr. S. K. Singh

Cited by 26 publications

References 0 publications

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ2S,S-S2C–piperazine–C2H4N(H)ClNQ}n]

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ2S,S-S2C–piperazine–C2H4N(H)ClNQ}n]

Derivatives of 4, 4’‐Oxydianiline Show Distinct In Vitro Cytotoxicity, Apoptosis Induction, and Selectivity against HepG2 Cancer Cells

Antimetastatic Activity of Gallic Acid‐conjugated Chitosan against Pulmonary Metastasis of Colon Carcinoma Cells

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Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]

Synthesis, electrochemical, fluorescence and antimicrobial studies of 2-chloro-3-amino-1,4-naphthoquinone bearing mononuclear transition metal dithiocarbamate complexes [M{κ²S,S-S₂C–piperazine–C₂H₄N(H)ClNQ}_n]