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Martínez, Melissa; Tandra, Anand; Vuppalanchi, Raj

doi:10.1002/hep.27542

Cited by 2 publications

(2 citation statements)

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“…After 6 months, one patient died, and one patient underwent liver transplantation. Two of the patients with fatal or liver transplantation outcomes had preexisting chronic liver disease (Martinez et al 2014). …”

Section: Antibioticsmentioning

confidence: 98%

“…This can be due to less common use of erythromycin nowadays. Interestingly, a new macrolide, azithromycin, has been found to be associated with cholestatic liver injury that can be severe (Martinez et al 2014). Among patients identified in the DILIN study, 18 had azithromycin-induced liver injury, which occurred most commonly 1-3 weeks after the initiation of the drug.…”

Section: Antibioticsmentioning

confidence: 99%

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Drug-induced liver injury: an overview over the most critical compounds

Bjõrnsson

2015

Arch Toxicol

121

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There has been a substantial interest in drug-induced liver injury (DILI) recently. National Institutes of Health has sponsored a multicenter study in the USA for the last 10 years, which has collected valuable information in this context. Idiosyncratic DILI is like other adverse effects of drugs underestimated and underreported in most epidemiological studies. A recent prospective population-based study from Iceland found a crude incidence of approximately 19 cases per 100,000 and year. Antibiotic is the class of drugs most commonly implicated in patients with DILI. Amoxicillin-clavulanate continues to be the most commonly implicated agent occurring in approximately 1 out of 2,300 users. Drugs with the highest risk of DILI in the Icelandic study were azathioprine and infliximab. Although rare, statin-induced hepatotoxicity has been well documented. Liver injury associated with the use of herbal medicines and dietary supplements seems to be increasing. Information on the documented hepatotoxicity of drugs has recently been made easier by a website available in the public domain: LiverTox ( http://livertox.nlm.nih.gov ). Unfortunately, at the current time, pre-therapy risk assessment for DILI in the individual patient is difficult but previous well-documented hepatotoxicity is usually a contraindication for a subsequent treatment with the same drug.

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Section: Antibioticsmentioning

confidence: 98%

Section: Antibioticsmentioning

confidence: 99%

Drug-induced liver injury: an overview over the most critical compounds

Bjõrnsson

2015

Arch Toxicol

121

View full text Add to dashboard Cite

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Portal vein thrombosis in cirrhosis: Controversies and latest developments

Harding¹,

Perera²,

Chen³

et al. 2015

WJG

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Portal vein thrombosis (PVT) is encountered in liver cirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication. We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation, and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%. PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions.

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Cited by 2 publications

References 5 publications

Drug-induced liver injury: an overview over the most critical compounds

Drug-induced liver injury: an overview over the most critical compounds

Portal vein thrombosis in cirrhosis: Controversies and latest developments

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