Reply to Slesak et al.: So much about
            <i>Rickettsia felis</i>
            infection to be discovered

Parola, Philippe; Mediannikov, Oleg; Dieme, Constentin; Raoult, Didier

doi:10.1073/pnas.1517919112

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…R. felis is also usually detected in cat fleas, although not in Senegal [15] . Anopheles gambiae mosquitoes are suspected to transmit the bacterium; this was strongly supported by a recent experimental model [16] , [17] . R. felis was also detected in a nonhaematophagous ubiquitous household pest, the booklouse Liposcelis bostrychophila, which also may play a role in the R. felis transmission [18] .…”

mentioning

confidence: 66%

Emerging infectious diseases in Africa in the 21st century

Fénollar¹,

Mediannikov

2018

New Microbes and New Infections

133

105

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Many infectious diseases have emerged or reemerged in Africa in the 21st century. Some of them are associated with newly discovered microorganisms such as Rickettsia felis and Tropheryma whipplei; others are known, historical diseases such as plague and cholera. In addition are diseases related to previously known microorganisms which recently have been involved for the first time in massive outbreaks with worldwide impacts (such as Ebola virus, Zika virus and Chikungunya virus). Research on emerging infectious diseases needs to be identified as a priority.

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confidence: 66%

Emerging infectious diseases in Africa in the 21st century

Fénollar¹,

Mediannikov

2018

New Microbes and New Infections

133

105

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“…8 Later, the ability of Anopheles mosquitoes to acquire and transmit R. felis to susceptible hosts was proven in an experimental model. [7][8][9] Here, we report additional evidence of the connecting epidemiologies of both diseases. Dielmo and Ndiop are two villages in the Sine-Saloum region of Senegal situated 5 km from each other, with a total population about 800 persons and where the point-of-care laboratory was installed in 2011 10 to perform rapid detection of both pathogens.…”

mentioning

confidence: 53%

“…5 These observations led us to the hypothesis that R. felis may be transmitted by mosquitoes in tropical countries. [7][8][9] We have reported the correlation between mosquito-transmitted malaria and R. felis infection regarding geographic distribution, seasonality, asymptomatic infections, and a potential vector. 5 Ricketsia felis has been also detected in wild Anopheles and in Aedes.…”

mentioning

confidence: 99%

Parallel Decline of Malaria and Rickettsia felis Infections in Senegal

Mediannikov

Abat

Sokhna

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…LSU-Lb to infect vertebrates is unknown, but rickettsial DNA has been detected in dust samples (containing L. bostrychophila and other dust-associated arthropods) collected from the beds of R. felis -infected patients in Senegal ( Mediannikov et al 2014 ). While not confirmed, it is postulated that these individuals may have acquired R. felis by inhalation or dermal inoculation of booklouse feces ( Parola et al 2015 ). Therefore, although R. felis str.…”

Section: Discussionmentioning

confidence: 99%

Effect of Rickettsia felis Strain Variation on Infection, Transmission, and Fitness in the Cat Flea (Siphonaptera: Pulicidae)

Healy

Brown

Hagstrom

et al. 2017

Journal of Medical Entomology

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Rickettsia felis is a human pathogen transmitted by the cat flea, Ctenocephalides felis (Bouché) (str. LSU), as well as an obligate symbiont of the parthenogenic booklouse Liposcelis bostrychophila (Badonnel) (str. LSU-Lb). The influence of genetic variability in these two strains of R. felis on host specialization and fitness and possible resulting differences on infection and transmission kinetics in C. felis is unknown. Utilizing an artificial host system, cat fleas were exposed to a R. felis str. LSU-Lb-infected bloodmeal and monitored for infection at 7-d intervals for 28 d. Quantitative real-time PCR was used to determine rickettsial load and infection density in newly exposed cat fleas, and transmission frequency between cat fleas. The effect of persistent R. felis infection on cat flea F1 progeny was also assessed. At 7 d postexposure 76.7% of the cat fleas successfully acquired R. felis str. LSU-Lb. In R. felis str. LSU-Lb-exposed cat fleas, the mean infection load (6.15 × 106), infection density (0.76), and infection prevalence (91/114) were significantly greater than R. felis str. LSU infection load (3.09 × 106), infection density (0.68), and infection prevalence (76/113). A persistent R. felis str. LSU-Lb infection was detected for 28 d in adult cat fleas but neither female:male ratio distortion nor vertical transmission was observed in F1 progeny. While infection kinetics differed, with higher intensity associated with R. felis str. LSU-Lb, no distinct phenotype was observed in the F1 progeny.

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Reply to Slesak et al.: So much about Rickettsia felis infection to be discovered

Cited by 11 publications

References 6 publications

Emerging infectious diseases in Africa in the 21st century

Emerging infectious diseases in Africa in the 21st century

Parallel Decline of Malaria and Rickettsia felis Infections in Senegal

Effect of Rickettsia felis Strain Variation on Infection, Transmission, and Fitness in the Cat Flea (Siphonaptera: Pulicidae)

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