Report of the American Heart Association (AHA) Scientific Sessions 2012, Los Angeles

Fujita, Jun

doi:10.1253/circj.cj-12-1490

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…14, 15 Because of its invaluable influence on preventing recurrent ischemic attacks, dual or even triple antiplatelet therapy has become the cornerstone of treatment in patients with CAD. 16, 17 Despite concerns for consequent risk of hemorrhagic complications, increasing evidence favors a certain level of platelet inhibition at the time of surgery to maximize the ischemic benefit and improve the postoperative outcome. 7, 8 In that context, OPCAB is proposed to be a safe surgical technique without increased risk of bleeding in patients requiring continued DAT.…”

Section: Discussionmentioning

confidence: 99%

Impact of Preoperative Fibrinogen Concentration on Postoperative Outcome in Patients Who Received Dual Antiplatelet Therapy in Proximity to Off-Pump Coronary Bypass Surgery

Kim

Shim

Song

et al. 2014

Circ J

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Background: Preoperative fibrinogen concentration is associated with increased blood loss at the lower end, and with hypercoagulability-related ischemic event at the higher end in cardiac patients. We evaluated the influence of preoperative fibrinogen concentration on blood loss and outcome in patients who received clopidogrel in proximity to off-pump coronary artery bypass surgery (OPCAB). Methods and Results:Medical records of 538 patients who received clopidogrel within 5 days of OPCAB (April 2007 to March 2012) were retrospectively reviewed. Perioperative bleeding and composite of morbidity endpoints including myocardial infarction were compared in relation to the tertile distribution of the fibrinogen concentration. The amount of blood loss was significantly larger in the first tertile, whereas the incidence of composite of morbidity endpoints was significantly higher in the third tertile. In multivariate analysis for risk factors of perioperative blood loss, body mass index and duration of surgery were identified as independent risk factors but not the fibrinogen level. And hypertension and preoperative fibrinogen level were identified as independent risk factors about composite of morbidity. The third tertile was associated with a 2-fold increased risk of developing composite of morbidity endpoints. Conclusions:In patients who received dual antiplatelet therapy in proximity to OPCAB, increased preoperative fibrinogen concentration could serve as a valuable predictor for composite of morbidity endpoints, whereas low fibrinogen concentration was not found to be a risk factor of bleeding. (Circ J 2014; 78: 1661 -1666

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Section: Discussionmentioning

confidence: 99%

Impact of Preoperative Fibrinogen Concentration on Postoperative Outcome in Patients Who Received Dual Antiplatelet Therapy in Proximity to Off-Pump Coronary Bypass Surgery

Kim

Shim

Song

et al. 2014

Circ J

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“…Emerging principles of epigenetics in vascular growth may provide major new mechanisms for translation and to overcome current limitations of pro-and antiangiogenic medicine [80]. As reported at the American Heart Association Scientific Sessions in 2012, regenerative medicine is now a major interest of CV research with genome wide association studies and epigenetics strong features of both basic and clinical CV research [81]. Such a role of epigenetics in regenerative medicine has several ongoing trials and basic research projects underway relevant to the immense potential of induced pluripotent stem cells (IPSCs) in particular to change approaches to CV disease and pluripotent stem cells have special interest for regenerative medicine and individualized CV therapies [81].…”

Section: Regenerative Medicine As a Modification Of Epigeneticsmentioning

confidence: 99%

“…As reported at the American Heart Association Scientific Sessions in 2012, regenerative medicine is now a major interest of CV research with genome wide association studies and epigenetics strong features of both basic and clinical CV research [81]. Such a role of epigenetics in regenerative medicine has several ongoing trials and basic research projects underway relevant to the immense potential of induced pluripotent stem cells (IPSCs) in particular to change approaches to CV disease and pluripotent stem cells have special interest for regenerative medicine and individualized CV therapies [81]. However, Sun et al point out that there are currently many problems with IPSCs and their potential derivation from adult somatic cells that interdict their clinical use [82].…”

Section: Regenerative Medicine As a Modification Of Epigeneticsmentioning

confidence: 99%

Epigenetics in the development, modification, and prevention of cardiovascular disease

Whayne

2014

Mol Biol Rep

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Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and its related conditions are no exception. Epigenetics is defined as the study of heritable alterations in gene expression, or cellular phenotype, and goes far beyond a pure genetic approach. A more precise definition is that epigenetics represents all the meiotically and mitotically inherited changes in gene expression that are not encoded on the deoxyribonucleic acid (DNA) sequence itself. Major epigenetic mechanisms are modifications of histone proteins in chromatin and DNA methylation (which does not alter the DNA sequence). There is increasing evidence for the involvement of epigenetics in human disease such as cancer, inflammatory disease and CV disease. Other chronic diseases are also susceptible to epigenetic modification such as metabolic diseases including obesity, metabolic syndrome, and diabetes mellitus. There is much evidence for the modification of epigenetics by nutrition and exercise. Through these modifications, there is infinite potential for benefit for the fetus, the newborn, and the individual as well as population effects. Association with CV disease, including coronary heart disease and peripheral vascular disease, is evident through epigenetic relationships and modification by major CV risk factors such as tobacco abuse. Aging itself may be altered by epigenetic modification. Knowledge of epigenetics and its relevance to the development, modification, and prevention of CV disease is in a very preliminary stage but has an infinite future.

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“…42,44-46 Newer studies, such as ALCADIA, implement a hybrid approach, combining growth factors with CSCs. 47 Furthermore, the CDC population will be additionally tested in Phase II studies to evaluate the efficacy of the autologous (RECONSTRUCT – NCT01496209) or allogeneic (ALLSTAR – NCT01458405) derivation paradigms in the treatment of ischemic heart disease.…”

Section: Introductionmentioning

confidence: 99%

Regenerative Principles Enrich Cardiac Rehabilitation Practice

Behfar

Terzic

Perez‐Terzic

2014

American Journal of Physical Medicine &Amp; Rehabilitation

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Cardiovascular morbidity imposes a high degree of disability and mortality, with limited therapeutic options available in end-stage disease. Integral to standard-of-care, cardiac rehabilitation aims on improving quality of life and prolonging survival. The recent advent of regenerative technologies paves the way for a transformative era in rehabilitation medicine whereby, beyond controlling risk factors and disease progression, the prospect of curative solutions is increasingly tangible. To date, the spectrum of clinical experience in cardiac regenerative medicine relies on stem cell-based therapies delivered to the diseased myocardium either acutely/subacutely, following a coronary event, or in the setting of chronic heart failure. Application of autologous/allogeneic stem cell platforms has established safety and feasibility, with encouraging signals of efficacy. Newer protocols aim to purify cell populations in an attempt to eliminate non-regenerative and enrich for regenerative cell types prior to use. Most advanced technologies have been developed to isolate resident cell populations directly from the heart, or alternatively condition cells from non-cardiac sources to attain a disease targeted lineage-specified phenotype for optimized outcome. As a multiplicity of cell-based technologies has undergone Phase I/II evaluation, pivotal trials are currently underway in larger patient populations. Translation of regenerative principles into clinical practice will increasingly involve rehabilitation providers across the continuum of patient care. Regenerative rehabilitation is thus an emerging multidisciplinary field, full of opportunities and ready to be explored.

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Report of the American Heart Association (AHA) Scientific Sessions 2012, Los Angeles

Cited by 11 publications

References 19 publications

Impact of Preoperative Fibrinogen Concentration on Postoperative Outcome in Patients Who Received Dual Antiplatelet Therapy in Proximity to Off-Pump Coronary Bypass Surgery

Impact of Preoperative Fibrinogen Concentration on Postoperative Outcome in Patients Who Received Dual Antiplatelet Therapy in Proximity to Off-Pump Coronary Bypass Surgery

Epigenetics in the development, modification, and prevention of cardiovascular disease

Regenerative Principles Enrich Cardiac Rehabilitation Practice

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