Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension

Abstract

The National Heart, Lung, and Blood Institute convened a multidisciplinary working group of hypertension researchers on December 6 to 7, 2018, in Bethesda, MD, to share current scientific knowledge in hypertension and to identify barriers to translation of basic into clinical science/trials and implementation of clinical science into clinical care of patients with hypertension. The goals of the working group were (1) to provide an overview of recent discoveries that may be ready for testing in preclinical and clinical studies; (2) to identify gaps in knowledge that impede translation; (3) to highlight the most promising scientific areas in which to pursue translation; (4) to identify key challenges and barriers for moving basic science discoveries into translation, clinical studies, and trials; and (5) to identify roadblocks for effective dissemination and implementation of basic and clinical science in real-world settings. The working group addressed issues that were responsive to many of the objectives of the National Heart, Lung, and Blood Institute Strategic Vision. The working group identified major barriers and opportunities for translating research to improved control of hypertension. This review summarizes the discussion and recommendations of the working group.

Recommended Management of Hypertensive Patients with Diabetes for Renin-Angiotensin System (RAS) Inhibitors

“…Intervention Trial) data showed that intensively controlled blood pressure could significantly reduce mortality and CVD events [3]. There has been a report of the National Heart, Lung, and Blood Institute Working Group on Hypertension [4]. can reduce cardiovascular mortality [5].…”

Impact of Casein- versus Grain-Based Diets on Rat Renal Sodium Transporters’ Abundance and Regulation

“…1 A component of the hypertension trend can be assigned to lifestyle trends including consumption of higher sodium/lower potassium diets suggesting that reducing these trends could reduce the incidence of hypertension. [1][2][3][4] For these reasons, definition of molecular mechanisms connecting dietary electrolyte consumption to blood pressure are essential. Pre-clinical studies varying electrolyte intake in rodents utilize synthetic casein-based chows in which the composition (e.g.…”

Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension

“…We want to introduce briefly the two most common inducible models as they form the basis for the largest part of the studies, which are cited in this review. Detailed overviews over all the existing genetic and inducible animal models including their advantages, disadvantages, and translation to human hypertension can be found elsewhere [6][7][8].…”