Report of Three Cases of Minimal Change Disease Following the Second Dose of mRNA SARS-CoV-2 COVID-19 Vaccine

Salem, Fadi; Rein, Joshua L.; Yu, Sherry H.; Abramson, Matthew; Cravedi, Paolo; Chung, Miriam

doi:10.1016/j.ekir.2021.07.017

Cited by 29 publications

(34 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minimal change disease (MCD) was the most common histopathology reported following COVID-19 vaccination (eleven new onset and eight relapsed cases), with nephrotic syndrome as the common presentation in these cases (see Table 1). A total of eleven cases presenting with de novo nephrotic syndrome following COVID-19 vaccination were diagnosed with MCD on kidney histopathology [9][10][11][12][13][14][15][16][17][18][19]. The median interquartile range (IQR) age of this group was 63 (50 to 75) years, with a male predominance (7:4).…”

Section: Minimal Change Diseasementioning

confidence: 99%

See 1 more Smart Citation

New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review

Kalra

Chinnadurai

2021

Vaccines

View full text Add to dashboard Cite

Introduction: The introduction of COVID-19 vaccination programs has become an integral part of the major strategy to reduce COVID-19 numbers worldwide. New-onset and relapsed kidney histopathology have been reported following COVID-19 vaccination, sparking debate on whether there are causal associations. How these vaccines achieve an immune response to COVID-19 and the mechanism that this triggers kidney pathology remains unestablished. We describe the results of a systematic review for new-onset and relapsed kidney histopathology following COVID-19 vaccination. Methods: A systematic literature search of published data up until 31 August 2021 was completed through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guideline. Research articles reporting new onset or relapsed kidney histopathology in adult patients (>18 years) following COVID-19 vaccination were included for qualitative review. Only full-text articles published in the English language were selected for review. Results: Forty-eight cases from thirty-six articles were included in the qualitative synthesis of this systematic review. Minimal change disease (19 cases) was the most frequent pathology observed, followed by IgA nephropathy (14 cases) and vasculitis (10 cases). Other cases include relapse of membranous nephropathy, acute rejection of kidney transplant, relapse of IgG4 nephritis, new-onset renal thrombotic microangiopathy, and scleroderma renal crisis following COVID-19 vaccination. There was no mortality reported in any of the included cases. Patients in all but one case largely recovered and did not require long-term renal replacement therapy. Conclusion: This systematic review provides insight into the relationship between various kidney pathologies that may have followed COVID-19 vaccination. Despite these reported cases, the protective benefits offered by COVID-19 vaccination far outweigh its risks. It would be recommended to consider early biopsy to identify histopathology amongst patients presenting with symptoms relating to new-onset kidney disease following vaccination and to monitor symptoms for those with potential relapsed disease.

show abstract

Section: Minimal Change Diseasementioning

confidence: 99%

“…There were eight relapsed MCD cases reported following COVID-19 vaccination in patients who had a previous histopathological diagnosis of MCD [13,[20][21][22][23][24]. The median (IQR) age of this group was 34 (31 to 40) years, with an equal distribution between males and females.…”

Section: Minimal Change Diseasementioning

confidence: 99%

New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review

Kalra

Chinnadurai

2021

Vaccines

View full text Add to dashboard Cite

show abstract

“…In our search of the literature, we found eight adult cases of new-onset nephrotic syndrome, mostly MCD, after SARS-CoV-2 vaccination (Table 2 ) [ 3 – 10 ]. Six patients had received mRNA vaccines (five had received BNT162b2) and two had received vector vaccines.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrence of nephrotic syndrome triggered by a SARS-CoV-2 vaccine has been reported [ 3 ]. Additionally, several cases of nephrotic syndrome, mostly minimal change disease (MCD), have been reported in adults after SARS-CoV-2 vaccination [ 3 – 10 ]. Hypertension and acute kidney injury (AKI) are present at high frequencies among these adult cases.…”

Section: Introductionmentioning

confidence: 99%

New-onset pediatric nephrotic syndrome following Pfizer-BioNTech SARS-CoV-2 vaccination: a case report and literature review

et al. 2021

View full text Add to dashboard Cite

“…To the Editor, Ever since the global administration of various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in response to the coronavirus disease 2019 (Covid-19), temporal associations between glomerulopathies and vaccination have been reported. 1 Minimal change disease (MCD) 1 , 2 , 3 and perhaps tip lesion variant of focal segmental glomerulosclerosis (FSGS) 2 along the spectrum of primary podocytopathies may develop shortly after vaccination against Covid-19 (i.e., <6 weeks), suggesting a direct role of the vaccine. Likewise, MCD has been associated with immunization against other viruses.…”

mentioning

confidence: 99%

Primary Podocytopathies After COVID-19 Vaccination

Timmermans

Busch

Abdul‐Hamid

et al. 2022

Kidney International Reports

View full text Add to dashboard Cite

Report of Three Cases of Minimal Change Disease Following the Second Dose of mRNA SARS-CoV-2 COVID-19 Vaccine

Cited by 29 publications

References 4 publications

New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review

New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review

New-onset pediatric nephrotic syndrome following Pfizer-BioNTech SARS-CoV-2 vaccination: a case report and literature review

Primary Podocytopathies After COVID-19 Vaccination

Contact Info

Product

Resources

About