Reporte de caso Adenocarcinoma de celulas basales de glandula parotida: estudio clinico/patologico e inmunohistoquimico

Abstract

Basal cell adenocarcinoma is an epithelial neoplasm with the cytological characteristics of basal cell adenoma but with a morphological pattern of infiltrative growth indicative of malignancy. Due to its low incidence it is often difficult to diagnose a basal cell adenocarcinoma. The objective of the present study was to identify morphological and immunohistochemical characteristics that contribute to its diagnosis. A parotid tumor was resected in a 52-year-old patient; postoperative biopsy and immunostaining with Ki-67, CK19, p63 and alpha-smooth muscle actin were performed. It was diagnosed basal cell adenocarcinoma that invades the tumor capsule, periglandular fat and lymph nodes. Immunostaining with Ki-67, CK19, p63 and alpha-smooth muscle actin was positive. Subsequently, a maxillary sinus metastasis was diagnosed. The morphological characteristics, Ki-67 expression strongly positive and metastasis give the malignant character to this tumor, which differentiates it from the basal cell adenoma.

Basal Cell Adenocarcinoma Arising from the Parotid Gland

“…However, the definition of high-risk characteristics is not yet well established. Despite recent advances that add value to the genetic background, the most determined predictors of adverse prognosis are tumor size (T3 or T4 tumors) and perineural invasion [ 8 ].…”