Reported evidence of vitamin E protection against cataract and glaucoma

Tanito, Masaki

doi:10.1016/j.freeradbiomed.2021.10.027

Cited by 30 publications

(10 citation statements)

References 160 publications

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“…There is still much work to be conducted to understand the mechanism of action of vitamin E in relation to eye care. Clinical studies regarding the effects of this vitamin are still needed and are not conclusive [ 331 , 332 ]. These views have been confirmed in a large-scale systematic review by Matthew et al [ 333 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…The Recommended Dietary Allowance for adults is 15 mg daily for men and women [ 19 ]; however, we found a median vitamin E consumption of 8.85 mg/day in our participants. Vitamin E is an essential micronutrient that participates in the prevention and treatment of cardiovascular, neurological and aging-related diseases [ 32 , 33 ] and also decreases insulin resistance and other cardiometabolic risk factors [ 34 ]. Regarding eye health, low levels of vitamin E in the aqueous humor have been associated with glaucoma [ 35 ], while other studies on dietary vitamin E intake and OAG did not reveal significant associations [ 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

et al. 2022

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Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants’ dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55–0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (≥55 year). Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma.

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“…What’s more, they also found applying vitamin E loading solutions, with 0.1 and 0.2 g/mL concentrations, could effectively enhance cipro release time from 2 hours (in a non-vitamin E–loaded lens) to 14 to 17 and 30 to 33 days, respectively (Rad et al., 2016 ; Rad & Mohajeri, 2017 ). Moreover, the strong antioxidant properties of vitamin E can improve the stability of combined drugs, protect the cornea from UV radiation, and inhibit the process underlying conditions such as cataracts and age-related macular degeneration (Palazzo et al., 2020 ; Tanito, 2021 ; Edwards et al., 2022 ). The advantages of vitamin E in prolonging drug release time without affecting important properties of lens and the strong antioxidant properties are beneficial for the development of drug delivery contact lenses.…”

Section: Novel Methods For Preparing Drug-loaded Contact Lensesmentioning

confidence: 99%

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

Zhao

Song

et al. 2023

Drug Delivery

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Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by many problems, including low bioavailability and potential drug side effects. Innovative ophthalmic drug delivery systems have been proposed to overcome the limitations associated with traditional formulations. Recently, contact lens-based drug delivery systems have gained popularity owing to their advantages of sustained drug delivery, prolonged drug retention, improved bioavailability, and few drug side effects. Various methods have been successfully applied to drug-loaded contact lenses and prolonged the drug release time, such as chemical crosslinking, material embedding, molecular imprinting, colloidal nanoparticles, vitamin E modification, drug polymer film/coating, ion ligand polymerization systems, and supercritical fluid technology. Contact lens-based drug delivery systems play an important role in the treatment of multifarious ophthalmic diseases. This review discusses the latest developments in drug-loaded contact lenses for the treatment of ophthalmic diseases, including preparation methods, application in ophthalmic diseases and future prospects.

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Reported evidence of vitamin E protection against cataract and glaucoma

Cited by 30 publications

References 160 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

ACE-Vitamin Index and Risk of Glaucoma: The SUN Project

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

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