The estimation of the global burden of measles is challenging in the absence of reliable and comparable surveillance systems worldwide. A static model is described that enables estimation of measles morbidity, mortality, and disability for the year 2000 on the basis of country-specific information (i.e., demographic profile, vaccine coverage, and estimates of case-fatality ratios). This approach estimated a global incidence of 39.9 million measles cases, 777,000 deaths, and 28 million disability-adjusted life years. The World Health Organization regions of Africa and Southeast Asia had 70% of incident cases and 84% of measles-related deaths; 11 countries alone (Afghanistan, Burkina Faso, Democratic Republic of the Congo, Ethiopia, India, Indonesia, Niger, Nigeria, Pakistan, Somalia, Uganda) account for 66% of deaths. This approach quantifies the measles burden by considering country-specific indicators, which can be updated, permitting an assessment of country, regional, and global changes in the burden associated with measles infection.The World Health Organization (WHO) estimated that about 875,000 children died of measles in 1999 [1]. This is 56% of all estimated deaths from vaccine-preventable diseases of childhood for that year, making measles the leading cause of vaccine-preventable child mortality. In 1989 the World Health Assembly set specific goals for the reduction in measles morbidity and mortality [2]. The continued commitment and effort is shown in the recent Strategic Plan for Measles Mortality and Morbidity Reduction [3].Because measles is both an epidemic and endemic