Reporting pH-sensitive drug releaseviaunpaired spin fluorescence silencing

Abstract

We pioneer an approach for the visualization of a self-reporting pH-controlled molecular release of a fluorescent drug from a nitroxide polymer scaffold.

Release of Fragrances from Polymer Coatings Triggered by Contact with Sweat

“…The amount of benzaldehyde released from the coatings was much higher than the odor threshold, which can be detected by humans (0.35 ppm in water and 8 × 10 –7 ppm in the gas phase). In the literature, doxorubicin bound to various polymers by hydrazone linkages was released from polymers in acidic conditions. − In our work, the release was much more sustained over time due to the fact that the active monomer containing the fragrance was in a relatively hydrophobic coating. The release of fragrances extracted from polyamide films, chitosan/poly­(vinyl alcohol)/β-cyclodextrin nanofibers, and zein films with organic solvents was also investigated by GC–MS but not from responsive and cleavable polymers.…”

Visible Light Activation of Spin‐Silenced Fluorescence

“…Technologies capable of self‐reporting molecular release events in a simple and unambiguous fashion are of critical importance to inform on the fate of molecules after a defined molecular scission event. Thus, self‐reporting systems have received substantial interest in a wide range of fields including smart materials, medical materials, medical imaging, and drug delivery . Specifically, the utilization of (pro)fluorophores has proven to be a reliable self‐reporting methodology when combined with polymer chemistry such as polymer/Au nanoparticles, single chain polymer nanoparticles, thin films, redox reporting, and polymer ligation systems .…”

“…Thus, self-reportings ystems have received substantial interest in aw ide range of fields including smart materials, [1] medicalm aterials, [2] medical imaging, [3] and drug delivery. [4] Specifically,t he utilization of (pro)fluorophores has provent ob eareliable self-reportingm ethodology when combined with polymer chemistry such as polymer/Au nanoparticles, [5] single chain polymern anoparticles, [6] thin films, [7] redox reporting, [8] and polymer ligations ystems. [9] As demonstrated previously by our team, [10] pyrene is apowerful synthon in the design of profluorescents elf-reporting systemsa si ts fluorescencec an be readily quenched-and reactivated-via the unpaired spin of paramagnetic nitroxide radicals.…”

Chemical design and synthesis of macromolecular profluorescent nitroxide systems as self-reporting probes

“…37 Recently, a profluorescent nitroxide probe based on the fluorescence quenching of doxorubicin in combination with a pHlabile hydrazide group was established as a pH-sensitive, selfreporting drug-release system. 51 A biocompatible polymer based on tert-butyloxycarbonyl-hydrazidomethacrylate (bHMA), triethyleneglycol methacrylate (TEGMA) and tetramethylpiperidinyl methacrylate (TMPM) was synthesized via reversible addition-fragmentation transfer (RAFT) polymerization. Upon oxidation of the amine functional group, doxorubicin was incorporated in the polymer backbone.…”