Reposição de GH na "somatopausa": solução ou problema ?

Bronstein, Marcello D.

doi:10.1590/s0004-27302003000400005

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…After the peak of GH levels during puberty, the hormone levels in the GH/IGF-1 axis gradually decline, and by 60 years of age, many healthy individuals have 24-hour GH levels indistinguishable from those with adult growth hormone deficiency (AGHD) due to hypothalamic-pituitary lesions [3].…”

Section: Introductionmentioning

confidence: 99%

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Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Rucker¹,

Sá²,

Arbex³

2017

Health

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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as "anti-aging" therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.

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Section: Introductionmentioning

confidence: 99%

“…Unlike patients with AGHD, both sleep and physical exercise persist as physiological stimuli for GH secretion in healthy elderly people [3].…”

Section: Introductionmentioning

confidence: 99%

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Rucker¹,

Sá²,

Arbex³

2017

Health

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“…The GH secretion declines gradually with age, whereby studies demonstrate a progressive reduction of 14% secretion per decade of life beginning in the second decade [ 2 , 3 ]. These findings suggest a possible association between GHD and the ageing process [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

Tavares

Micmacher

Biesek

et al. 2013

International Journal of Endocrinology

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Growth hormone (GH) use has been speculated to improve physical capacity in subjects without GH deficiency (GHD) through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect of GH therapy on muscle strength in healthy men over 50 years old. Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.). Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group). Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness. The trial was registered with NCT01853566.

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Novas opções e preparações na terapia com hormônio de crescimento

Aguiar‐Oliveira

Meneguz‐Moreno

Nascimento-Junior

2008

Arq Bras Endocrinol Metab

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RESUMOnos últimos 20 anos, o hormônio de crescimento recombinante humano (gHhr) vem sendo utilizado para tratar a deficiência do hormônio de crescimento (gH) em crianças e, mais recentemente, em adultos. Porém, a necessidade de injeções diárias compromete a aderência ao tratamento. esforços de melhorar esta aderência incluem o uso de canetas e dispositivos desprovidos de agulha, haja vista que as bombas de infusão, nem sempre são fisiológicas e são de uso restrito. quando a finalidade do tratamento for o crescimento, a terapêutica diária com gHhr continua a mais recomendada. contudo, a expansão da terapêutica com gH, especialmente nos usos mais recentes e em adultos, necessitará de outras preparações. no momento atual, os secretagogos orais não têm eficácia comprovada para a utilização clínica, e as formulações de depósito de gHrH e de gH, que melhorariam a aderência dos pacientes, ainda requerem mais estudos de eficácia em longo prazo e segurança. ABSTRAcTNews Options and Preparations in Growth Hormone Therapy. in the last twenty years, recombinant human growth hormone (hrgH) has been available for the treatment of growth Hormone deficiency (gHd) in children and more recently in adults. However, the necessity of daily injections compromises the patient's compliance. Attempts to improve this compliance includes the use of pens and needle free devices, once the infusion pumps, not always physiologic, are of restricted use. When growth is the purpose of treatment, daily subcutaneous hrgH is still the most indicated. nevertheless the expansion of gH replacement to new uses and especially in adults will need new preparations. nowadays, the oral secretagogues have not proved efficacy to be used in clinical practice and the slow-release preparations of gH and gH releasing hormone that could improve the patient's compliance will need to be studied considering long term efficacy and safety. (1). Desde 1986, o GH recombinante humano (GHhr) vem sendo usado para tratar crianças com deficiência de GH (DGH) e déficit de crescimento (2,3). Posteriormente, foi reconhecido que o GH não é somente requerido

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Reposição de GH na "somatopausa": solução ou problema ?

Cited by 4 publications

References 43 publications

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

Novas opções e preparações na terapia com hormônio de crescimento

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