Representation of American Blacks in Clinical Trials of New Drugs

Svensson, Craig K.

doi:10.1001/jama.1989.03420020117041

Cited by 120 publications

(36 citation statements)

References 8 publications

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“…In fact, only 58% of these studies reported race/ethnicity of enrolled subjects versus 91% reporting gender and 80% reporting age. This represents an improvement, however, over an earlier review finding that only 20% of 50 published clinical trials of new drugs included any racial data (103). In some areas of research, particularly prevention studies involving relatively healthy volunteers, reporting of sample race/ethnicity is even less common.…”

Section: Methodsmentioning

confidence: 93%

Effective Recruitment and Retention of Minority Research Participants

Yancey

Ortega

Kumanyika

2006

Annu. Rev. Public Health

998

1,107

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describing methods of increasing minority enrollment and retention in research studies, more than three times the average annual output of scholarly work in this area during the prior 15-year period. Ten themes emerged from the 75 studies that were primarily descriptive. The remaining 20 studies, which directly analyzed the efficacy or effectiveness of recruitment/retention strategies, were examined in detail and provided useful insights related to four of the ten factors: sampling approach/identification of targeted participants, community involvement/nature and timing of contact with prospective participants, incentives and logistical issues, and cultural adaptations. We then characterized the current state of this literature, discussing implications for future research needs and directions.

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Section: Methodsmentioning

confidence: 93%

Effective Recruitment and Retention of Minority Research Participants

Yancey

Ortega

Kumanyika

2006

Annu. Rev. Public Health

998

1,107

View full text Add to dashboard Cite

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“…Although there are safeguards in place to protect subjects in human experimentation, these measures have not erased the fear among many African Americans that they will be abused for the sake of medical research (Gamble 1993). This fear of medical research has contributed to the low participation rates and subsequent under-representation of African Americans in clinical trials (King, 1992;Sevensson, 1989;Smith, 1991). However, successful recruitment of African Americans into research has been done and is possible.…”

Section: Subject Recruitmentmentioning

confidence: 99%

A Registry of Adult African American Twins: The Carolina African American Twin Study of Aging

Whitfield

2012

Twin Res Hum Genet

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Twin studies have seldom addressed ethnicity as one of the possible factors that create unique combinations of genetic and environmental influences. The major objective of the Carolina African American Twin Study of Aging is to identify the proportion of the genetic and environmental sources of individual variation in measures of health and behavioral factors in a sample of adult African Americans. Drawn from birth records from the State of North Carolina, this in-person study used public records to identify a cohort of twins between 22 and 92 years of age (X = 49.82 yrs, SD = 14.62), 39.7% of which were men. Members of non-intact twin pairs and siblings were also recruited to explore alternative models to the classic twin design. To date, the project has contributed to knowledge about blood pressure, forced expiratory volume, chronic illness, body mass index, and waist-hip ratio memory, personality, social, and demographic factors, mortality, and mental health.

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“…People of color and low-income people have been historically underrepresented in clinical trials, thus bringing into question the applicability of the results of those trials to the patients we treat. 24,25 Enrolling more CHC patients in clinical trials would greatly enhance the state of clinical information available in the United States.…”

Section: Role Of Community Health Centers In Advancing Knowledge How mentioning

confidence: 99%

Using Information Technology to Improve Health Quality and Safety in Community Health Centers

Calman¹,

Kitson²,

Hauser³

2007

cpr

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Problem-Community health centers (CHCs) face a unique set of challenges and can learn much from each other as they prepare for the adoption of health information technology (HIT).Purpose-This paper presents a research agenda aimed at providing information CHCs will need to successfully implement HIT.Key Points-Community health centers must be able to evaluate whether an investment in HIT is the best way to achieve improvements in health outcomes for their communities given the limited resources and high demands they face. Community health centers need better information to guide them in selecting and implementing information technology that will result in improved health quality and safety. Guidance in optimal use of the system, particularly in the effective use of data made available through electronic health records, is needed to realize health care goals. Community health centers need to be active participants in HIT developments in their communities to ensure that their patients benefit from technological advancements that improve health care. Keywordselectronic health records; health information technology; community health centers; health care quality; health care safety Community health centers (CHCs), like many other health care settings, are expanding their use of information technology to improve health care and health outcomes for their patients. Health information technology (HIT) has been defined as "the application of information processing involving both computer hardware and software that deals with the storage, retrieval, sharing, and use of health care information, data, and knowledge for communication and decision-making." 1 It is considered fundamental to improving the quality of health care. 2 At our organization, the Institute for Urban Family Health, we implemented a fully integrated electronic health record (EHR) and practice management system at our primary care practice sites four years ago. Drawing on our experience using EHRs and our review of the medical literature on the impact of HIT on the quality and safety of patient care at CHCs and other primary care sites, we have developed a set of research questions for the CHC community to consider as it moves forward in the implementation of HIT. STRATEGIC PLANNING FOR HEALTH QUALITY AND SAFETY IMPROVEMENTS How Do CHCs Determine Whether an Investment in HIT will help?As HIT proliferates throughout the country, we must assess the extent to which it will achieve expected goals. The health care system does not have sufficient resources to engage in this expensive new technology without tracking its return on investment-not only financially, but NIH Public Access

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Representation of American Blacks in Clinical Trials of New Drugs

Cited by 120 publications

References 8 publications

Effective Recruitment and Retention of Minority Research Participants

Effective Recruitment and Retention of Minority Research Participants

A Registry of Adult African American Twins: The Carolina African American Twin Study of Aging

Using Information Technology to Improve Health Quality and Safety in Community Health Centers

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