Representation of the cochlear partition on the superior temporal plane of the macaque monkey

Merzenich, Michael M.; Brugge, John F.

doi:10.1016/0006-8993(73)90731-2

Cited by 721 publications

(439 citation statements)

References 22 publications

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“…Neuroimaging techniques allow for the non‐invasive investigation of the functional organization of the auditory cortex (AC) in the human brain: In agreement with previous animal studies (e.g., cats and primates; Merzenich and Brugge, 1973; Merzenich et al, 1973), functional magnetic resonance imaging (fMRI) studies have found a tonotopic organization of the human early AC (Da Costa et al, 2011; Formisano et al, 2003; Humphries et al, 2010; Langers and van Dijk, 2012; Talavage et al, 2004; Woods et al, 2010). Human early AC tonotopy has been consistently described as two frequency gradients composing a high‐low‐high preferred frequency pattern located in and around the Heschl's gyrus (HG).…”

Section: Introductionsupporting

confidence: 81%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

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A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective regions using, for the first time, cerebral blood flow (CBF). We demonstrated the feasibility of CBF‐based tonotopy and found a good agreement with BOLD signal‐based tonotopy, despite the lower contrast‐to‐noise ratio of CBF. Quantitative perfusion mapping of baseline CBF showed a region of high perfusion centered on Heschl's gyrus and corresponding to the main high‐low‐high frequency gradients, co‐located to the presumed primary auditory core and suggesting baseline CBF as a novel marker for AC parcellation. Furthermore, susceptibility weighted imaging was employed to investigate the tissue specificity of CBF and BOLD signal and the possible venous bias of BOLD‐based tonotopy. For BOLD only active voxels, we found a higher percentage of vein contamination than for CBF only active voxels. Taken together, we demonstrated that both baseline and stimulus‐induced CBF is an alternative fMRI approach to the standard BOLD signal to study auditory processing and delineate the functional organization of the auditory cortex. Hum Brain Mapp 38:1140–1154, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Introductionsupporting

confidence: 81%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

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“…A tonotopic map with isofrequency contours similar to that of rabbits has been reported in an Australian marsupial (Aitkin et al, 1986) and in ferrets (Angelucci et al, 1993). In most mammalian species, the primary auditory field is surrounded by one or more tonotopically organized areas (Tunturi, 1950;Merzenich and Brugge, 1973;Reale and Imig, 1980;Redies et al, 1989;Hackett et al, 1998). In the rabbit, a secondary field with a tonotopic organization that mirrors AI lies dorsal to AI.…”

Section: Auditory Cortical Maps In the Rabbit: Comparison With Other mentioning

confidence: 99%

Functional Subregions in Primary Auditory Cortex Defined by Thalamocortical Terminal Arbors: An Electrophysiological and Anterograde Labeling Study

et al. 2003

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Several functional maps have been described in primary auditory cortex, including those related to frequency, tuning, latency, binaurality, and intensity. Many of these maps are arranged in a discontinuous or patchy manner. Similarly, thalamocortical projections arising from the ventral division of the medial geniculate body to the primary auditory cortex are also patchy. We used anterograde labeling and electrophysiological methods to examine the relationship between thalamocortical patches and auditory cortical maps. Biotinylated dextran-amine was deposited into physiologically characterized sites in the ventral division of the medial geniculate body of New Zealand white rabbits. Approximately 7 d later, the animal was again anesthetized and the ipsilateral auditory cortex was mapped with tungsten microelectrodes. Multi-unit physiological data were obtained for the following characteristics: best frequency (BF), binaurality, response type, latency, sharpness of tuning, and threshold. Immunocytochemical methods were used to reveal the injection site in the ventral division of the medial geniculate body as well as the anterogradely labeled thalamocortical afferents in the auditory cortex. In 86% of the cases (12 of 14), entry into a thalamocortical patch was associated with a marked change in physiological responses. A consistent BF and binaural class were usually observed within a patch. The patches appear to innervate distinct functional regions coding frequency and binaurality. A model is presented showing how patchy thalamocortical projections participate in the formation of tonotopic and binaural maps in primary auditory cortex.

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“…This tonotopy also exists throughout the auditory pathway up to the primary auditory cortex. The first studies describing this cortical organization were made in monkeys (Merzenich and Brugge, 1973) and in cats (Merzenich et al, 1975).…”

Section: Introductionmentioning

confidence: 99%

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

et al. 2004

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The aim of the present study was to investigate the functional organization of the auditory cortex for pure tones of 1, 2, 4, 6, 8 and 12 kHz. Ten subjects were tested with a whole-head magnetometer (151 channels). The location, latency and amplitude of the generators of the N1m (the main component of the response, peaking approximately at 100 ms) were explored simultaneously in the right and left hemispheres under monaural stimulation. Our results revealed that tonotopy is a rather complex functional organization of the auditory cortex. From 1 to 12 kHz, tonotopic maps were found for contralateral as well as for ipsilateral stimulation: N1m generators were found to be tonotopically organized mainly in an anterior-posterior direction in both hemispheres, whatever the stimulated ear, but also in an inferior-superior direction in the right hemisphere. Furthermore, latencies were longer in the left than in the right hemisphere. Two different representations of spectral distribution were found in the right auditory cortex: one for ipsilateral and one for contralateral stimulation.

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Representation of the cochlear partition on the superior temporal plane of the macaque monkey

Cited by 721 publications

References 22 publications

Tonotopic maps in human auditory cortex using arterial spin labeling

Tonotopic maps in human auditory cortex using arterial spin labeling

Functional Subregions in Primary Auditory Cortex Defined by Thalamocortical Terminal Arbors: An Electrophysiological and Anterograde Labeling Study

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

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