Abstract. We derive an adjunction inequality for any smooth, closed, connected, oriented 4-manifold X with b + = 1. This inequality depends only on the cohomology algebra and generalizes the inequality of Strle in the case of b1 = 0. We demonstrate that the inequality is especially powerful when 2χ+3σ ≥ 0, whereχ is the modified Euler number taking account of the cup product on H 1 (X; Z).