Reprint of: Blood culture time-to-positivity: making use of the hidden information

Lamy, Brigitte

doi:10.1016/j.cmi.2019.03.005

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…TTD of positive blood cultures might be a relevant parameter in comparing different patient populations [15]. In the present study we showed that the mean TTD in COVID-19 was approximately 20% longer compared to controls.…”

Section: Plos Onesupporting

confidence: 56%

Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19

Ininbergs

Hedman

et al. 2020

PLoS ONE

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Purpose In the management of COVID-19, knowledge is lacking on the frequency of secondary bacterial infections and on how empirical antibiotic therapy should be used. In the present study, we aimed to compare blood culture (BC) results of a COVID-19 patient cohort with two cohorts of patients without detected COVID-19. Methods Using a retrospective cohort study design of patients subjected to BC in six tertiary care hospitals, SARS-CoV-2 positive patients from March 1 to April 30 in 2020 (COVID-19 group) were compared to patients without confirmed SARS-CoV-2 during the same period (control group-2020) and with patients sampled March 1 to April 30 in 2019 (control group-2019). The outcomes studied were proportion of BC positivity, clinically relevant growth, and contaminant growth. Results In total 15,103 patients and 17,865 BC episodes were studied. Clinically relevant growth was detected in 197/3,027 (6.5%) BC episodes in the COVID-19 group compared to 717/6,663 (10.8%) in control group-2020 (p<0.0001) and 850/8,175 (10.4%) in control group-2019 (p<0.0001). Contamination was present in 255/3,027 (8.4%) BC episodes in the COVID-19 group compared to 330/6,663 (5.0%) in control group-2020 (p<0.0001) and 354/8,175 (4.3%) in control group-2019 (p<0.0001). Conclusion In COVID-19 patients, the prevalence of bloodstream bacterial infection is low and the contamination rate of BC is high. This knowledge should influence guidelines regarding blood culture sampling and empirical antibiotic therapy in COVID-19 patients.

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Section: Plos Onesupporting

confidence: 56%

Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19

Ininbergs

Hedman

et al. 2020

PLoS ONE

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“…Though one should consider that TTP may be challenging to interpret, provides indirect information on the biomass and is associated with many other confounding factors (e.g. blood volume per bottle, conditions of cultures, transportation time, concomitant anti-infectives or sample type) [24,25]. Previous studies have demonstrated that a delay in loading the bottles into the incubator decreases the TTP, which was calculated by subtracting the time of receipt in the laboratory from the time required to detect a positive culture [26].…”

Section: Discussionmentioning

confidence: 99%

On-site blood culture incubation shortens the time to knowledge of positivity and microbiological results in septic patients

et al. 2019

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“…As TTP varies among different pathogen species, the cut-off TTP values were also widely ranged from 7 h to 7 d among different microorganisms in previous studies [ 3 , 8 ]. TTP provides potential biomass information regarding bacteraemia load and microbial growth rate, correlated to the extent of systemic inflammatory response and organ injury [ 26 , 27 ]. A meta-analysis analysed previous TTP studies for comparison, and most (72%) studies reported a significant relationship between mortality and short TTP, regardless of the pathogen species [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…We adopted both surgical and non-surgical manoeuvres as source control methods but did not consider their timing, which also influenced the outcomes [ 1 , 24 ]. The interpretation of TTP has been associated with other confounding factors in previous studies, including blood sampling volume and methods, culture conditions, prior antibiotic therapy, and time of transportation for incubation [ 26 ]. As the sampling and culture methods are unified in our institution, we admitted that the transportation time and concomitant antibiotic administration were not controlled in our study, which is similar to most previous TTP studies [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study

Yang,

Tsai,

Lai

et al. 2024

Virulence

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Klebsiella pneumoniae is a common causative pathogen of intra-abdominal infection with concomitant bacteraemia, leading to a significant mortality risk. The time to positivity (TTP) of blood culture is postulated to be a prognostic factor in bacteraemia caused by other species. Therefore, this study aimed to investigate the prognostic value of TTP in these patients. The single-centred, retrospective, observational cohort study was conducted between 1 July 2016 and 30 June 2021. All adult emergency department patients with diagnosis of intra-abdominal infection and underwent blood culture collection which yield K. pneumoniae during this period were enrolled. A total of 196 patients were included in the study. The overall 30-day mortality rate was 12.2% (24/196), and the median TTP of the studied cohort was 12.3 h (10.5–15.8 h). TTP revealed a moderate 30-day mortality discriminative ability (area under the curve 0.73, p < 0.001). Compared with the late TTP group (>12 h, N = 109), patients in the early TTP (≤12 h, N = 87) group had a significantly higher risk of 30-day morality (21.8% vs. 4.6%, p < 0.01) and other adverse outcomes. Furthermore, TTP (odds ratio [OR] = 0.79, p = 0.02), Pitt bacteraemia score (OR = 1.30, p = 0.03), and implementation of source control (OR = 0.06, p < 0.01) were identified as independent factors related to 30-day mortality risk in patients with intra-abdominal infection and K. pneumoniae bacteraemia. Therefore, physicians can use TTP for prognosis stratification in these patients.

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Reprint of: Blood culture time-to-positivity: making use of the hidden information

Cited by 5 publications

References 12 publications

Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19

Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19

On-site blood culture incubation shortens the time to knowledge of positivity and microbiological results in septic patients

Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study

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