Reprint of: The Thiobarbituric Acid Reaction and the Autoxidations of Polyunsaturated Fatty Acid Methyl Esters

Dahle, Leland K.; Hill, Eldon G.; Holman, Ralph T.

doi:10.1016/j.abb.2022.109250

Cited by 1 publication

(1 citation statement)

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“…This could be explained by the different biological fluids analyzed (serum vs. urine), but most probably by the detection method; in fact, spectrophotometric TBARS determination is nonspecific for MDA since the thiobarbituric acid test measures reactive substances other than MDA, such as 2-alkenals and 2,4-alkadienals [ 37 ]. It was also demonstrated that the lack of specificity of the spectrophotometric TBARS determination limited the detection of differences in the level of lipid peroxidation in biological samples observed by HPLC detection [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Significance of Serum Oxidative and Antioxidative Status in Congenital Central Hypoventilation Syndrome (CCHS) Patients

et al. 2022

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Congenital central hypoventilation syndrome (CCHS) is a rare neurological genetic disorder that affects sleep-related respiratory control. Currently, no drug therapy is available. In light of this, there is a need for lifelong ventilation support, at least during sleep, for these patients. The pathogenesis of several chronic diseases is influenced by oxidative stress. Thus, determining oxidative stress in CCHS may indicate further disorders in the course of this rare genetic disease. Liquid biopsies are widely used to assess circulating biomarkers of oxidative stress. In this study, ferric reducing ability of plasma, thiobarbituric acid-reactive substances, advanced oxidation protein products (AOPPs), and advanced glycation end-products were measured in the serum of CCHS patients to investigate the relationship between oxidative stress and CCHS and the significance of this balance in CCHS. Here, AOPPs were found to be the most relevant serum biomarker to monitor oxidative stress in CCHS patients. According to this communication, CCHS patients may suffer from other chronic pathophysiological processes because of the persistent levels of AOPPs.

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Section: Resultsmentioning

confidence: 99%