Reproducibility and variability of very low dose hepatic perfusion CT in metastatic liver disease

Topçuoğlu, Osman Melih; Karçaaltıncaba, Muşturay; Akata, Deniz; Ozmen, Mustafa

doi:10.5152/dir.2016.16612

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Generated parametric maps are vendor-specific, and as a result, radiologists need to acquire experience and establish intra-institutional reference values before using CTLP in HCC diagnosis. However, great effort has been made to standardize CTLP acquisition protocols [ 117 ] and reduce radiation exposure [ 118 , 119 , 120 ]. With the advent of comparative studies to indicate when the additional use of CT perfusion might be beneficial for the patient and further development of automated image analysis software, CTLP might reach the availability of brain perfusion, which has a central role in the management of stroke [ 121 ].…”

Section: Ct Perfusionmentioning

confidence: 99%

Current Imaging Diagnosis of Hepatocellular Carcinoma

Chartampilas

Rafailidis

Georgopoulou

et al. 2022

Cancers

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Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer related death worldwide. Radiology has traditionally played a central role in HCC management, ranging from screening of high-risk patients to non-invasive diagnosis, as well as the evaluation of treatment response and post-treatment follow-up. From liver ultrasonography with or without contrast to dynamic multiple phased CT and dynamic MRI with diffusion protocols, great progress has been achieved in the last decade. Throughout the last few years, pathological, biological, genetic, and immune-chemical analyses have revealed several tumoral subtypes with diverse biological behavior, highlighting the need for the re-evaluation of established radiological methods. Considering these changes, novel methods that provide functional and quantitative parameters in addition to morphological information are increasingly incorporated into modern diagnostic protocols for HCC. In this way, differential diagnosis became even more challenging throughout the last few years. Use of liver specific contrast agents, as well as CT/MRI perfusion techniques, seem to not only allow earlier detection and more accurate characterization of HCC lesions, but also make it possible to predict response to treatment and survival. Nevertheless, several limitations and technical considerations still exist. This review will describe and discuss all these imaging modalities and their advances in the imaging of HCC lesions in cirrhotic and non-cirrhotic livers. Sensitivity and specificity rates, method limitations, and technical considerations will be discussed.

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Section: Ct Perfusionmentioning

confidence: 99%

Current Imaging Diagnosis of Hepatocellular Carcinoma

Chartampilas

Rafailidis

Georgopoulou

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…8,12 The use of CT scanners with wide area detectors, development of motion correction algorithms, and low dose and dual-source protocols are strategies that have proven useful to solve these issues. 1,[13][14][15][16] Nevertheless, to allow a broader use of perfusion CT, further challenges remain, including the lack of standardization in data analysis and the paucity of studies on the agreement regarding quantification of liver perfusion parameters. 8,11 Thus, the aim of our study was to evaluate the agreement between the measurements of perfusion CT parameters in normal livers by using two software packages available from two major CT manufacturers.…”

Section: Bjrmentioning

confidence: 99%