Reproducibility of [11C]FLB 457 binding in extrastriatal regions

Sudo, Yasuhiko; Suhara, Tetsuya; Inoue, Makoto; Ito, Hiroshi; Suzuki, Kazutoshi; Saijo, Tomoyuki; Halldin, Christer; Farde, Lars

doi:10.1097/00006231-200111000-00008

Cited by 63 publications

(48 citation statements)

References 19 publications

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“…Voxelwise [11C] FLB-457 binding potential (BP) was calculated using a simplified reference tissue (cerebellum) method (Gunn et al, 1997;Lammertsma and Hume, 1996;Sudo et al, 2001). …”

Section: Scanning Proceduresmentioning

confidence: 99%

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Ray

Miyasaki

Zurowski

et al. 2012

Neurobiology of Disease

121

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Impulse control disorders such as pathological gambling (PG) are a serious and common adverse effect of dopamine (DA) replacement medication in Parkinson's disease (PD). Patients with PG have increased impulsivity and abnormalities in striatal DA, in common with behavioural and substance addictions in the non-PD population. To date, no studies have investigated the role of extrastriatal dopaminergic abnormalities in PD patients with PG. We used the PET radiotracer, [11C] FLB-457, with high-affinity for extrastriatal DA D2/3 receptors. 14 PD patients on DA agonists were imaged while they performed a gambling task involving real monetary reward and a control task. Trait impulsivity was measured with the Barratt Impulsivity Scale (BIS). Seven of the patients had a history of PG that developed subsequent to DA agonist medication. Change in [11C] FLB-457 binding potential (BP) during gambling was reduced in PD with PG patients in the midbrain, where D2/D3 receptors are dominated by autoreceptors. The degree of change in [11C] FLB-457 binding in this region correlated with impulsivity. In the cortex, [11C] FLB-457 BP was significantly greater in the anterior cingulate cortex (ACC) in PD patients with PG during the control task, and binding in this region was also correlated with impulsivity. Our findings provide the first evidence that PD patients with PG have dysfunctional activation of DA autoreceptors in the midbrain and low DA tone in the ACC. Thus, altered striatal and cortical DA homeostasis may incur vulnerability for the development of PG in PD, linked with the impulsive personality trait.

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“…Voxelwise [11C] FLB-457 binding potential (BP) was calculated using a simplified reference tissue (cerebellum) method (Gunn et al, 1997;Lammertsma and Hume, 1996;Sudo et al, 2001). …”

Section: Scanning Proceduresmentioning

confidence: 99%

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Ray

Miyasaki

Zurowski

et al. 2012

Neurobiology of Disease

121

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“…For instance, during the performance of working memory tasks, DA release increases in the PFC (Aalto et al, 2005a;Sawamoto et al, 2008), and anterior cingulate cortex (ACC) DA receptor density has been shown to be significantly correlated with performance level on the WCST in normal control subjects (Lumme et al, 2007). Recently, Ko et al (2009) (Figure 6) addressed the role of prefrontal DA during set-shifting tasks in healthy subjects by using [ 11 C]FLB 457, a chemical compound with a greater affinity (Kd ¼ 20 nM) for D2 receptors, which allows evaluation of extrastriatal DA release (Aalto et al, 2005a;Olsson et al, 1999;Sudo et al, 2001). Olsson et al (2004) had previously shown that [ 11 C]FLB 457 BP calculated by simplified reference tissue model (Gunn et al, 1997;Lammertsma and Hume, 1996;Sudo et al, 2001) may provide a reasonable estimate of receptor densities in different extrastriatal areas (for example, in cingulate cortex, frontal cortex, thalamus, and temporal cortex), consistent with postmortem studies using [ 125 I]epidepride (Kessler et al, 1993).…”

Section: Pet Studiesmentioning

confidence: 99%

“…Recently, Ko et al (2009) (Figure 6) addressed the role of prefrontal DA during set-shifting tasks in healthy subjects by using [ 11 C]FLB 457, a chemical compound with a greater affinity (Kd ¼ 20 nM) for D2 receptors, which allows evaluation of extrastriatal DA release (Aalto et al, 2005a;Olsson et al, 1999;Sudo et al, 2001). Olsson et al (2004) had previously shown that [ 11 C]FLB 457 BP calculated by simplified reference tissue model (Gunn et al, 1997;Lammertsma and Hume, 1996;Sudo et al, 2001) may provide a reasonable estimate of receptor densities in different extrastriatal areas (for example, in cingulate cortex, frontal cortex, thalamus, and temporal cortex), consistent with postmortem studies using [ 125 I]epidepride (Kessler et al, 1993). Similarly, [ 11 C]FLB 457 has been shown to be sensitive in detecting changes in extrastriatal endogenous DA concentration in non-human primates (Chou et al, 2000) and in humans (Aalto et al, 2005a, b;Hagelberg et al, 2004;Montgomery et al, 2007 (Narendran et al, 2009).…”

Section: Pet Studiesmentioning

confidence: 99%

The Neural Circuitry of Executive Functions in Healthy Subjects and Parkinson's Disease

Leh

Petrides

Strafella

2009

Neuropsychopharmacol

176

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In our constantly changing environment, we are frequently faced with altered circumstances requiring generation and monitoring of appropriate strategies, when novel plans of action must be formulated and conducted. The abilities that we call upon to respond accurately to novel situations are referred to as 'executive functions', and are frequently engaged to deal with conditions in which routine activation of behavior would not be sufficient for optimal performance. Here, we summarize important findings that may help us understand executive functions and their underlying neuronal correlates. We focus particularly on observations from imaging technology, such as functional magnetic resonance imaging, position emission tomography, diffusion tensor imaging, and transcranial magnetic stimulation, which in the past few years have provided the bulk of information on the neurobiological underpinnings of the executive functions. Further, emphasis will be placed on recent insights from Parkinson's disease (PD), in which the underlying dopaminergic abnormalities have provided new exciting information into basic molecular mechanisms of executive dysfunction, and which may help to disentangle the cortical/subcortical networks involved in executive processes.

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“…Voxelwise [ 11 C]FLB 457 BP was calculated using a simplified reference tissue (cerebellum) method (Gunn et al, 1997;Lammertsma and Hume, 1996;Sudo et al, 2001) to generate statistical parametric images of change in BP (Aston et al, 2000). This method uses the residuals of the least-square fit of the compartmental model to the data at each voxel to estimate the standard deviation of the BP estimate.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

“…MCST) in healthy human subjects, we used [ 11 C]FLB 457, a chemical compound with a greater affinity (K d =20 nM) for D2 receptors which allows evaluation of extrastriatal dopamine release (Aalto et al, 2005a;Olsson et al, 1999;Sudo et al, 2001). In previous reports, Olsson et al (2004) have shown that [ 11 C]FLB 457 BP calculated by simplified reference tissue model (Gunn et al,1997;Lammertsma and Hume,1996;Sudo et al, 2001) may provide a reasonable estimate of receptor densities in different extrastriatal areas (e.g. cingulate cortex, frontal cortex, thalamus, temporal cortex) consistent with postmortem study with [ 125 I]epidepride (Kessler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [11C]FLB 457 PET study

Ko¹,

Ptito²,

Monchi³

et al. 2009

NeuroImage

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There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D 2 -dopamine receptor ligand [ 11 C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [ 11 C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.

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Reproducibility of [11C]FLB 457 binding in extrastriatal regions

Cited by 63 publications

References 19 publications

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

The Neural Circuitry of Executive Functions in Healthy Subjects and Parkinson's Disease

Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [11C]FLB 457 PET study

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