Reproducibility of choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines

Koay, Chiang Ling; Quo, Matthew Justin; Subrayan, Visvaraja

doi:10.1007/s10792-016-0306-4

Cited by 11 publications

(10 citation statements)

References 21 publications

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“…Most examinations were performed using the Heidelberg Spectralis and Cirrus-OCT. However, the study by Koay et al did not show any statistically significant difference between the results concerning choroidal thickness measured by means of such equipment as SD-OCT: Zeiss Cirrus HD-OCT, Heidelberg Spectralis, and Optovue RTVue [ 34 ]. The repeatability of the SFCT measurements using various machines was also confirmed in the study by Yamashita et al [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

Roskal-Wałek

Laudańska-Olszewska²,

Biskup

et al. 2017

BioMed Research International

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Pregnancy is a time when many changes occur in a woman's body. The goal of these changes is the provision of optimum conditions for the development of the foetus. Pregnancy also affects eye physiology. Well recognized physiological changes include a reduced corneal sensitivity, an increase in its central thickness and curvature, and a decrease in intraocular pressure. The association between choroidal thickness and pregnancy is not clear. Haemodynamic and hormonal changes taking place during pregnancy and the question of whether these changes are reflected by choroidal thickness are especially important. It is assumed that the choroid, which is one of the most highly vascularized tissues characterized by the highest blood flow to tissue volume ratio in the whole body, should respond by an increase in its thickness to an increase in blood flow and drop in the value of peripheral resistance. Measurement of choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT) in women with uncomplicated pregnancy provides important information concerning the effects of physiological changes in the eye.

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Section: Discussionmentioning

confidence: 99%

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

Roskal-Wałek

Laudańska-Olszewska²,

Biskup

et al. 2017

BioMed Research International

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“…Previous studies have already demonstrated the reproducibility of this technique, even across different OCT systems. 31 – 33 CT was measured at ten different locations: at the fovea and every 500 µm from the fovea up to 2,500 µm temporally and up to 2,000 µm nasally ( Figure 1 ). We used the following abbreviations for the macular points: T5: CT at 2,500 µm temporally to the fovea; T4: CT at 2,000 µm temporally to the fovea; T3: CT at 1,500 µm temporally to the fovea; T2: CT at 1,000 µm temporally to the fovea; T1: CT at 500 µm temporally to the fovea; SF: CT at the fovea; N1: CT at 500 µm nasally to the fovea; N2: CT at 1,000 µm nasally to the fovea; N3: CT at 1,500 µm nasally to the fovea and N4: CT at 2,000 µm nasally to the fovea.…”

Section: Methodsmentioning

confidence: 99%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

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PurposeTo analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography.Patients and methodsThis cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy.ResultsThe comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements.ConclusionPregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM.

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“…Enhanced-depth imaging optical coherence tomography (EDI-OCT) was used to evaluate the choroid. 18,19…”

Section: Patient Selection and Imagingmentioning

confidence: 99%

Vascular Changes in the Retina and Choroid of Patients With EPAS1 Gain-of-Function Mutation Syndrome

et al. 2020

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IMPORTANCE Patients with the EPAS1 gain-of-function mutation syndrome (or Pacak-Zhuang syndrome) present with multiple paragangliomas or pheochromocytomas, duodenal somatostatinoma, polycythemia, headaches, and sometimes diminished visual acuity at an early age. The characteristic phenotype and known genetic cause of the syndrome provide an opportunity to study the role of hypoxia-inducible factor 2α (HIF-2α) in oxygen sensing, development in regions of physiologic hypoxia, and other pathological processes.OBJECTIVES To describe the ocular lesions in EPAS1 gain-of-function mutation syndrome and to establish whether early-onset diminished visual acuity is developmental or associated with long-term physiologic sequelae of the syndrome. DESIGN, SETTING, AND PARTICIPANTSThis clinical case series with a transgenic murine model study was conducted from July 2013 to June 2019. Participants were 3 patients referred by their primary care physicians to the National Institutes of Health for evaluation of recurrent and metastatic paragangliomas or pheochromocytomas accompanied by polycythemia. The syndrome and somatic mosaicism in patients were confirmed by the identification of gain-of-function mutations in the EPAS1 gene in resected tumors and other tissues. MAIN OUTCOMES AND MEASURESOcular findings in patients with EPAS1 gain-of-function mutation syndrome.RESULTS A total of 3 patients (mean [SD] age, 29 [6.2] years) with confirmed ocular abnormalities were included in the study. Increased contrast accumulation at the posterior aspect of the globe was seen bilaterally on magnetic resonance imaging scans in all patients. Ophthalmoscopy images demonstrated fibrosis overlying the optic disc, tortuous and dilated retinal vessels, and retinal pigment epithelium changes. Optic disc edema and retinal exudates were also seen. Fluorescein angiography images showed leakage of dye from postcapillary venules surrounding the optic disc and highlighted aberrant retinal vascular patterns. Enhanced-depth imaging optical coherence tomography images showed substantial thickening of the choroid and dilation of choroidal vessels. The ocular features of the syndrome were confirmed with a transgenic model of mice with gain-of-function Epas1 A529V mutation. CONCLUSIONS AND RELEVANCEIn this case series, HIF-2α and hypoxia signaling was found to have a role in vessel development within the choroid and retina, indicating that the marked permanent choroidal thickening and tortuous and dilated veins seen in the choroid and retina in patients with EPAS1 gain-of-function mutation syndrome were suggestive of the persistence of venous elements within the developing mesenchyme. These findings may explain other eye and vascular abnormalities whose pathogenesis remains unclear.

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Reproducibility of choroidal thickness measurements in subjects on 3 spectral domain optical coherence tomography machines

Cited by 11 publications

References 21 publications

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Vascular Changes in the Retina and Choroid of Patients With EPAS1 Gain-of-Function Mutation Syndrome

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