Reproducibility of high-resolution optical coherence tomography in multiple sclerosis

Syc, Stephanie B.; Warner, Christina; Hiremath, Girish; Farrell, Sheena K.; Ratchford, John N.; Conger, Amy; Frohman, Teresa C.; Cutter, Gary; Balcer, Laura J.; Frohman, Elliot M.; Calabresi, Peter A.

doi:10.1177/1352458510371640

Cited by 99 publications

(94 citation statements)

References 39 publications

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“…25,26 Utilizing the Heidelberg Spectralis ® HRA + OCT, we were able to demonstrate significant RNFL thinning in multiple sclerosis patients compared with controls. As well as in eyes with optic neuritis compared with those without optic neuritis.…”

Section: Discussionmentioning

confidence: 90%

Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography

Khanifar

Parlitsis

Ehrlich

et al. 2010

OPTH

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Purpose: Histopathologic studies have reported retinal nerve fiber layer (RNFL) thinning in various neurodegenerative diseases. Attempts to quantify this loss in vivo have relied on time-domain optical coherence tomography (TDOCT), which has low resolution and requires substantial interpolation of data for volume measurements. We hypothesized that the significantly higher resolution of spectral-domain optical coherence tomography (SDOCT) would better detect RNFL changes in patients with multiple sclerosis, and that RNFL thickness differences between eyes with and without optic neuritis might be identified more accurately. Methods: In this retrospective case series, patients with multiple sclerosis were recruited from the Judith Jaffe Multiple Sclerosis Center at Weill Cornell Medical College in New York. Patients with a recent clinical diagnosis of optic neuritis (less than three months) were excluded. Eyes with a history of glaucoma, optic neuropathy (other than multiple sclerosis-related optic neuritis), age-related macular degeneration, or other relevant retinal and/or optic nerve disease were excluded. Both eyes of each patient were imaged with the Heidelberg Spectralis ® HRA + OCT. RNFL and macular thickness were measured for each eye using the Heidelberg OCT software. These measurements were compared with validated published normal values, and were modeled as linear functions of duration of disease. The odds of an optic neuritis diagnosis as a function of RNFL and macular thickness were calculated. Results: Ninety-four eyes were prospectively evaluated using OCT. Ages of patients ranged from 26 to 69 years, with an average age of 39 years. Peripapillary RNFL thinning was demonstrated in multiple sclerosis patients; mean RNFL thickness was 88.5 µm for individuals with multiple sclerosis compared with a reported normal value of 97 µm (P , 0.001). Eyes with a history of optic neuritis had more thinning compared with those without optic neuritis (83.0 µm versus 90.5 µm, respectively, P = 0.02). No significant differences were observed in macular thickness measurements between eyes with and without optic neuritis, nor were macular thickness measurements significantly different from normal values. As a function of multiple sclerosis duration and controlling for age, RNFL thickness was decreased in patients with a duration of multiple sclerosis greater than five years compared with those with a duration less than or equal to one year (P = 0.008). Conclusions:Patients with a history of multiple sclerosis had RNFL thinning that was detectable on SDOCT. Decreasing RNFL thickness in eyes with optic neuritis was found, and the odds of having optic neuritis were increased significantly with decreasing RNFL thickness. Average RNFL thinning with increasing duration of disease was an excellent predictor of a reported history of optic neuritis. SDOCT retinal imaging may represent a high-resolution, objective, noninvasive, and easily quantifiable in vivo biomarker of the presence of optic neuritis and severity of multiple s...

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Section: Discussionmentioning

confidence: 90%

Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography

Khanifar

Parlitsis

Ehrlich

et al. 2010

OPTH

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“…Many of current generation SD-OCT device typically report an excellent ICC (i.e., greater than 90%) and coefficient of variation below 4.0% for the global average and quadrant circumpapillary RNFL. [7][8][9][10][11][12] It is important to note that ICC values are population specific, so their values are not comparable between studies. Despite our lack of eye tracking and registration software, the CV results from our study are comparable to SD-OCT studies that enrolled adult healthy controls and those with glaucoma.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] The intra-and intervisit reproducibility of SD-OCT circumpapillary RNFL measures has recently been enhanced by eye tracking and registration technology, typically yielding an intraclass correlation coefficient (ICC) greater than 90% and coefficient of variation below 4.0%. [7][8][9][10][11][12] Despite the addition of eye tracking technology, many infants, toddlers, and young children frequently cannot cooperate with traditional table-mounted SD-OCT imaging due to their young age and or comorbid medical conditions. The development of a handheld SD-OCT has enabled pediatric practitioners to acquire high resolution images of the circumpapillary RNFL and macula in neonates, infants and young children.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Avery¹,

Cnaan²,

Schuman³

et al. 2014

Journal of American Association for Pediatric Ophthalmology and

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“…Previous work by Cettomai et al [16] showed good levels of inter-rater and test-retest reliability for OCT 3 (Stratus) measurements of RNFL thickness in patients with MS and disease-free controls. A more recent study, however, demonstrated that high-resolution Fourier domain OCT techniques afford an even greater degree of reproducibility of RNFL thickness and macular volume assessments [32]. This prospective study of inter-visit, interrater, and intra-rater reproducibility was performed using Cirrus high-resolution OCT.…”

Section: Role For Oct In Modeling Axonal and Neuronal Loss In Msmentioning

confidence: 99%

“…Among 58 patients with MS and 32 healthy controls, there was excellent reproducibility of average and quadrantic RNFL thickness values, average macular thickness, and total macular volume; intraclass correlation coefficients ranged from 0.92 to 0.97 for inter-visit, 0.94 to 0.99 for inter-rater, and 0.83 to 0.99 for intra-rater reproducibility. The authors suggested that, in addition to implementing highresolution Fourier domain technology, the utilization of specific procedures, such as the reading of algorithms and quality control, can serve to optimize the quality of OCT data [32].…”

Section: Role For Oct In Modeling Axonal and Neuronal Loss In Msmentioning

confidence: 99%

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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Summary: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (RNFL), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure (no other central nervous system tract has this unique arrangement) for visualizing the processes of neurodegeneration, neuroprotection and, potentially, even neuro-repair. OCT is capable of providing high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and permits objective analysis of the RNFL (axons) as well as ganglion cells and other neurons in the macula. In a systematic OCT examination of multiple sclerosis (MS) patients, RNFL thickness and macular volumes are reduced when compared to disease-free controls.Conspicuously, these changes, which signify disorganization of retinal structural architecture, occur over time even in the absence of a history of acute demyelinating optic neuritis. RNFL axonal loss in MS is most severe in those eyes with a corresponding reduction in low-contrast letter acuity (a sensitive vision test involving the perception of gray letters on a white background) and in those patients who exhibit the greatest magnitude of brain atrophy, as measured by validated magnetic resonance imaging techniques. These unique structure-function correlations make the anterior visual pathway an ideal model for investigating the effects of standard and novel therapies that target axonal and neuronal degeneration. We provide an overview of the physics of OCT, its unique properties as a non-invasive imaging technique, and its potential applications toward understanding mechanisms of brain tissue injury in MS, other optic neuropathies, and neurologic disorders.

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Reproducibility of high-resolution optical coherence tomography in multiple sclerosis

Cited by 99 publications

References 39 publications

Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography

Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography

Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

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