Reproducibility of multifocal VEP latency using different stimulus presentations

Abstract

The aims of the article were to study the reproducibility of latency of multifocal visual evoked potential (mfVEP) recorded using different stimulus presentations and to identify the peak with least variability. Ten normal subjects, aged between 22 and 52 years (mean age 32 ± 8.37 years), participated in the study. All subjects underwent mfVEP testing with pattern reversal and pattern pulse stimulus presentations. The stimulus subtends 26° from fixation and includes 24 segments. Only the vertical channel was recorded on all subjects. Testing was repeated after 1-2 weeks. Only the right eye of all subjects was analysed. Segments with low signal-to-noise ratios (SNR < 1.5) were excluded from analysis. The latencies were analysed to confirm values from the same peak for the two tests. The latency values were then analysed for the start of the response, the first peak and the second peak. The waveforms were reproducible throughout the field. Reproducibility of latency at the "start of the response" was significantly lesser than the first and the second peaks studied, while the reproducibility of latency at the first peak was not statistically different from the second peak for either pattern reversal or pattern pulse stimulation. The latency values were not different between the first and the second sessions for either pattern reversal or pattern pulse stimulation for any of the peaks. The pattern reversal stimulus presentation produced less variability in latency. The first peak is the most reproducible among the three measures in both the stimulus presentation.

Retinal layers and visual conductivity changes in a case series of microangiopathic ischemic stroke patients

“…A limitation of our mfVEP study is that mfVEP repeatability was not assessed. However, previous investigations have reported a good reproducibility of first peak latency in mfVEP [37]. The negative findings of our SD-OCT analyses, which only partly contradicts a previous report by Wang and colleagues [31], might be explained by the small sample size, different ethnicity of the group (Caucasian versus Asian) and the analyses of only microangiopathic ischemic strokes and not ischemic strokes of all etiologies compared to the study of Wang et al [31].…”

Multifocal visual evoked potentials for quantifying optic nerve dysfunction in patients with optic disc drusen

“…Monocular latency was quantified by first selecting the mfVEP trace channel (H or V) with the largest P2P amplitude in the interval (70-210 ms) and was thereafter computed by a set of algorithms that identified the second highest peak of the waveform measuring the moment of time it presented (Sriram et al 2012). Interocular latencies were computed by cross-correlation between the best SNR channel of right and left eye (de Santiago et al 2015).…”

Empirical mode decomposition processing to improve multifocal-visual-evoked-potential signal analysis in multiple sclerosis

“…Delays in mfVEP latency signals are usually observed after an optic neuritis (ON) episode, reflecting optic nerve fiber demyelination, whereas shortening of the latency represents remyelination processes [ 19 , 20 ]. Interocular latency measurements are especially useful in the case of unilateral ON because a normal contralateral eye serves as a good control reference.…”