Reproducibility of <scp>3 T APT‐CEST</scp> in Healthy Volunteers and Patients With Brain Glioma

Wamelink, Ivar J.H.G.; Kuijer, Joost P.A.; Padrela, Beatriz E.; Zhang, Yi; Barkhof, Frederik; Mutsaerts, Henk‐Jan; Petr, Jan; Giessen, Elsmarieke van de; Keil, Vera C.

doi:10.1002/jmri.28239

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…21 healthy volunteers and 6 glioma patients (4 GBs, 1 oligodendroglioma, 1 radiologically suspected LGG). [32] APTw MRI max values correlate positively with rCBVmax.…”

Section: Mrimentioning

confidence: 79%

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Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Frosina

2024

Cancers

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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference to Italy. We suggest measures to accelerate the gradual progress in image-based models and end of life care for patients with high-grade glioma.

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“…21 healthy volunteers and 6 glioma patients (4 GBs, 1 oligodendroglioma, 1 radiologically suspected LGG). [32] APTw MRI max values correlate positively with rCBVmax.…”

Section: Mrimentioning

confidence: 79%

“…It may offer several potential clinical applications, but its reproducibility has to be adequately studied. Warmelink and colleagues reported that APTw MRI indeed exhibits good scan-rescan reproducibility in healthy tissue and HGG tumors with clinically usable scan times at 3 T [32] (Figure 3C-F) (Table 1).…”

Section: Major Finding Experimental Systemmentioning

confidence: 93%

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Frosina

2024

Cancers

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“…Some provide information that renders contrast-enhanced MRI unnecessary for specific indications. Amide proton transfer (APT) imaging, for example, is a chemical exchange saturation transfer (CEST) technique offering potential clinical applications for diagnosis, characterisation, and treatment planning and monitoring in glioma patients [ 84 ]. Multiple other specialised non-contrast MR Angiography techniques (e.g.…”

Section: Measures To Reduce Gbcamentioning

confidence: 99%

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Dekker,

Stroomberg,

Van der Molen

et al. 2024

Insights Imaging

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Gadolinium-based contrast agents (GBCA) are essential for diagnostic MRI examinations. GBCA are only used in small quantities on a per-patient basis; however, the acquisition of contrast-enhanced MRI examinations worldwide results in the use of many thousands of litres of GBCA per year. Data shows that these GBCA are present in sewage water, surface water, and drinking water in many regions of the world. Therefore, there is growing concern regarding the environmental impact of GBCA because of their ubiquitous presence in the aquatic environment. To address the problem of GBCA in the water system as a whole, collaboration is necessary between all stakeholders, including the producers of GBCA, medical professionals and importantly, the consumers of drinking water, i.e. the patients. This paper aims to make healthcare professionals aware of the opportunity to take the lead in making informed decisions about the use of GBCA and provides an overview of the different options for action.In this paper, we first provide a summary on the metabolism and clinical use of GBCA, then the environmental fate and observations of GBCA, followed by measures to reduce the use of GBCA. The environmental impact of GBCA can be reduced by (1) measures focusing on the application of GBCA by means of weight-based contrast volume reduction, GBCA with higher relaxivity per mmol of Gd, contrast-enhancing sequences, and post-processing; and (2) measures that reduce the waste of GBCA, including the use of bulk packaging and collecting residues of GBCA at the point of application.Critical relevance statement This review aims to make healthcare professionals aware of the environmental impact of GBCA and the opportunity for them to take the lead in making informed decisions about GBCA use and the different options to reduce its environmental burden.Key points• Gadolinium-based contrast agents are found in sources of drinking water and constitute an environmental risk.• Radiologists have a wide spectrum of options to reduce GBCA use without compromising diagnostic quality.• Radiology can become more sustainable by adopting such measures in clinical practice. Graphical Abstract

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“… 57 d. Measurement reliability: Reproducibility between vendors and sites is very important for clinical applicability of CEST, as it enables results from different cohorts to be compared. 58 – 60 Generally, there is no standardization for CEST postprocessing. However, recent consensus recommendations have been published to address this issue.…”

Section: Basic Physics Of Cestmentioning

confidence: 99%

Chemical Exchange Saturation Transfer MRI: What Neuro-Oncology Clinicians Need To Know

Jabehdar Maralani,

Chan,

Lam

et al. 2023

Technol Cancer Res Treat

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Chemical exchange saturation transfer (CEST) is a relatively novel magnetic resonance imaging (MRI) technique with an image contrast designed for in vivo measurement of certain endogenous molecules with protons that are exchangeable with water protons, such as amide proton transfer commonly used for neuro-oncology applications. Recent technological advances have made it feasible to implement CEST on clinical grade scanners within practical acquisition times, creating new opportunities to integrate CEST in clinical workflow. In addition, the majority of CEST applications used in neuro-oncology are performed without the use gadolinium-based contrast agents which are another appealing feature of this technique. This review is written for clinicians involved in neuro-oncologic care (nonphysicists) as the target audience explaining what they need to know as CEST makes its way into practice. The purpose of this article is to (1) review the basic physics and technical principles of CEST MRI, and (2) review the practical applications of CEST in neuro-oncology.

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Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

Cited by 8 publications

References 39 publications

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Review of strategies to reduce the contamination of the water environment by gadolinium-based contrast agents

Chemical Exchange Saturation Transfer MRI: What Neuro-Oncology Clinicians Need To Know

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