Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease

Puente-Maestu, Luís; Sánz, M L; Sánz, P.; Núñez, Asunción; Gonzalez, Fernando; Whipp, Brian J.

doi:10.1007/s004210100486

Cited by 44 publications

(31 citation statements)

References 21 publications

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“…The differences between the fC and V9O 2 kinetics might be one of the factors. It has been shown in COPD that fC kinetics are slower when compared with V9O 2 kinetics during exercise [8]. In addition, ventilatory limitation to exercise is often present in patients with COPD.…”

Section: Cardiopulmonary Stress and Exercise In Copd Vs Probst Et Almentioning

confidence: 99%

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Cardiopulmonary stress during exercise training in patients with COPD

Probst¹

2006

Eur Respir J

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Exercise training is an essential component of pulmonary rehabilitation. However, the cardiopulmonary stress imposed during different modalities of exercise training is not yet known.In the present study, the cardiopulmonary stress of a 12-week exercise training programme in 11 chronic obstructive pulmonary disease (COPD) patients (forced expiratory volume in one second 42¡12%pred, age 69¡6 yrs) was measured. Pulmonary gas exchange and cardiac frequency (fC) of three training sessions were measured with a portable metabolic system at the beginning, mid-term and end of the programme. Symptoms were assessed with Borg scores.The exercise intensity was compared with the recommendations for exercise training by the American College of Sports Medicine (ACSM). Training effects were significant (maximum change in work: 14¡11 Watts, 6-min walk test: 44¡36 m). Whole body exercises (cycling, walking and stair climbing) consistently resulted in higher cardiopulmonary stress (oxygen uptake (V9O 2 ), minute ventilation and fC) than arm cranking and resistance training. Dyspnoea was higher during cycling than resistance training. Patients exercised for .70% (.20 min) of the total exercise time at .40% of the V9O 2 reserve and fC reserve (''moderate'' intensity according to the ACSM) throughout the programme.The cardiopulmonary stress resistance training is lower than during whole-body exercise and results in fewer symptoms. In addition, exercise testing based on guidelines using a fixed percentage of baseline peak performance and symptom scores achieves and sustains training intensities recommended according to the American College of Sports Medicine.

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Section: Cardiopulmonary Stress and Exercise In Copd Vs Probst Et Almentioning

confidence: 99%

“…In addition, training intensity is conventionally set at a given fraction of an incremental peak exercise response. Due to the relatively slow oxygen uptake kinetics of patients with chronic diseases [7,8], the actual metabolic load during somewhat longer exercise bouts may well be underestimated.…”

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confidence: 99%

Cardiopulmonary stress during exercise training in patients with COPD

Probst¹

2006

Eur Respir J

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“…It is known that the on-kinetics of VO 2 and, as was more recently shown, of HR are slowed in the presence of COPD [3][4][5][6][7]16,35 and that these variables enable the inference of such patients' compromised exercise performance 3,4 . It was recently suggested that the BODE index is associated with COPD patients' slowed VO 2 on-kinetics 16 .…”

Section: Vo 2 and Hr On-kinetics And Its Relationship To The Bode Indmentioning

confidence: 99%

COPD patients' oxygen uptake and heart rate on-kinetics at cycle-ergometer: correlation with their predictors of severity

Pessoa¹,

Beltrame²,

Lorenzo³

et al. 2013

Braz. J. Phys. Ther.

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| Objectives: To assess whether there is a correlation between oxygen uptake (VO 2 ) and heart rate (HR) on-kinetics in the constant-load cycle-ergometer test (CLT) and the BODE index and its isolated variables in patients with chronic obstructive pulmonary disease (COPD). Method: Fourteen male patients between 55 and 78 years of age with moderate to severe COPD were evaluated. Each patient underwent spirometry, the six-minute walk test (6MWT), the cycle-ergometer incremental test (IT) and CLT on alternate days. The exhaled gases were collected, and the VO 2 and HR on-kinetics were analyzed. The BODE index was calculated. Results: It was noted that the VO 2 tau (τ) and mean response time (MRT) were significantly higher than HR τ and MRT. Moderate and strong correlations between τ and MRT of the VO 2 and HR and the BODE index was noted (r=0.75 and r=0.78; r=0.62 and r=0.63, respectively), and there were correlations between the VO 2 τ and MRT and the forced expiratory volume in one second (FEV 1 ) (r=-0.60; r=-0.53) and the distance traveled at 6MWT (DT-6MWT) (r=-0.61; r=-0.44) and DT-6MWT % predicted (r=-0.62; r=-0.46). The HR τ and MRT were correlated with DT-6MWT (r=-0.59; r=-0.58) and DT-6MWT % predicted (r=-0.62; r=-0.62). Conclusion: The slowing of cycle-ergometer VO 2 , and especially of HR on-kinetics, may be key markers of disease severity. Furthermore, airflow obstruction and reduced exercise capacity are associated with the slowing of patients' VO 2 and HR on-kinetics.

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“…In patients with very low exercise capacity (i.e. peak work rate ,40 W), the test was performed at 30 W to secure a V9O 2 amplitude that was sufficiently high for the kinetics analysis [24]. Assuming that resting TLC remains constant during exercise, changes in IC were taken to reflect variations in EELV (TLC -IC) [25].…”

Section: Cardiopulmonary Exercise Testsmentioning

confidence: 99%

Exercise tolerance with helium-hyperoxiaversushyperoxia in hypoxaemic patients with COPD

et al. 2012

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The purpose of this study was to investigate whether helium-hyperoxia (HeHOx) would allow greater tolerance to maximal and submaximal exercise compared to hyperoxia (HOx) on isolation in hypoxaemic chronic obstructive pulmonary disease (COPD) patients under long-term oxygen therapy.In a double-blind study, 24 males in the Global Initiative for Chronic Obstructive Lung Disease functional class IV (forced expiratory volume in 1 s 35.2¡10.1% predicted and arterial oxygen tension 56.2¡7.5 mmHg) were submitted to incremental and constant load cycling at 70-80% peak work rate while breathing HOx (60% nitrogen and 40% oxygen) or HeHOx (60% helium and 40% oxygen).HeHOx improved resting airflow obstruction and lung hyperinflation in all but two patients (p,0.05). Peak work rate and time to exercise intolerance were higher with HeHOx than HOx in 17 (70.8%) out of 24 patients and 14 (66.6%) out of 21 patients, respectively (p,0.05). End-expiratory lung volumes were lower with HeHOx, despite a higher ventilatory response (p,0.05). HeHOx speeded on-exercise oxygen uptake kinetics by ,30%, especially in more disabled and hyperinflated patients. Fat-free mass was the only independent predictor of higher peak work rate with HeHOx (r 2 50.66, p,0.001); in contrast, none of the resting characteristics or exercise responses were related to improvements in time to exercise intolerance (p.0.05).Helium is a valuable ergogenic aid when added to HOx for most long-term oxygen therapy-dependent patients with advanced COPD. @ERSpublications Helium is a valuable ergogenic aid when added to hyperoxia for most advanced COPD patients on long-term oxygen therapy

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Reproducibility of the parameters of the on-transient cardiopulmonary responses during moderate exercise in patients with chronic obstructive pulmonary disease

Cited by 44 publications

References 21 publications

Cardiopulmonary stress during exercise training in patients with COPD

Cardiopulmonary stress during exercise training in patients with COPD

COPD patients' oxygen uptake and heart rate on-kinetics at cycle-ergometer: correlation with their predictors of severity

Exercise tolerance with helium-hyperoxiaversushyperoxia in hypoxaemic patients with COPD

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