Reproducibility of Topographic Measurements of the Normal and Glaucomatous Optic Nerve Head With the Laser Tomographic Scanner

Dreher, Andreas W.; Tso, Patrick C.; Weinreb, Robert N.

doi:10.1016/s0002-9394(14)72263-9

Cited by 179 publications

(53 citation statements)

References 11 publications

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“…8 Results from these imaging technologies can be used to predict glaucoma development, [9][10][11][12][13] and have the potential to detect and measure structural progression. 7,[14][15][16][17][18][19][20][21][22][23][24] Recent literature has focused on the ability of these instruments to provide estimates of rates of change over time.…”

Section: Introductionmentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature. Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with nonprogressing glaucoma patients. Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials.

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Section: Introductionmentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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“…So far, SLO-studies have mainly evaluated the usefulness of optic disc parameters for glaucoma detection, their reproducibility of measurements and any correlations with visual field defects. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] However, relatively little attention has been paid to the possible value of SLO optic disc biometry for improvement of glaucoma follow-up. [20][21][22] To reliably detect development or progression of disease with a certain measurement parameter, it is necessary to know the absolute difference between follow-up measurements that must be exceeded to detect a statistically significant change over time.…”

Section: Introductionmentioning

confidence: 99%

Estimating the clinical usefulness of optic disc biometry for detecting glaucomatous change over time

Tangelder

Reus

Lemij

2005

Eye

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Purpose First, to determine the absolute measurement precision of scanning laser ophthalmoscopy (SLO) parameters, by expressing them as 95% limits of agreement (LA 95% ). Second, to propose a method for mathematically estimating the clinical ability of a parameter to monitor disease progression, expressed as the Discriminating Capacity Index (DCI). Methods We measured the optic disc of 14 healthy volunteers and 14 glaucoma patients. LA 95% -values were calculated from the average standard deviation of three measurements on the same day for repeatability, and three measurements on separate days within a 6-week period for reproducibility. We then calculated the DCI by dividing the measurement range by its LA 95% in healthy subjects and glaucoma patients separately. Thus, the DCI takes into account both the dynamic range of disease progression and the extent of measurement variance, providing an index of the possible clinical usefulness of a parameter. As the DCI is dimensionless it allows comparison across various parameters and across technologies.

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“…Even if each image is made by many points, users prefer to employ standard parameters for each system and do not use all the available data. [13][14][15][16][17][18][19][20][21][22] To obtain parameter measurements, an outline had to be drawn around the outer optic disc edge and although this technique had a good reproducibility, the contour line position could change from one center to another. 10 The anatomical variability of normal ONH shape makes it difficult to differentiate normal from glaucomatous optic discs.…”

Section: Discussionmentioning

confidence: 99%

“…The accuracy and reproducibility of this instrument have previously been described in detail. [13][14][15][16][17][18][19][20][21][22] The HRT uses a scanning confocal laser imaging system, which produces a series of 32 confocal images of the back of the eye at consecutive focal planes, each 256 Â 256 pixels. This series is converted by further processing into a single 3-D topographic image.…”

Section: Optic Nerve Head Topographic Analysismentioning

confidence: 99%