Reproductive and developmental toxicity of styrene

Brown, Nigel A.

doi:10.1016/0890-6238(91)90106-p

Cited by 23 publications

(17 citation statements)

References 80 publications

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“…A third study in mice did not discuss reproductive organs but reported that the levels of the metabolite styrene oxide were o10% of the styrene concentration in all organs examined. Some correlations were noted between cytochrome P450 activity of organs and styrene oxide levels (Brown, 1991).…”

Section: Experimental Animalmentioning

confidence: 98%

“…Styrene is distributed to fetuses of rats (Withey and Karpinski, 1985) and reproductive organs of rats and mice (Brown, 1991). Volume of distribution in humans was reported as 99 L or 1.4 L/kg (Wigaeus et al, 1983).…”

Section: Summary Of General Toxicologymentioning

confidence: 98%

“…The review by Brown (1991) discussed studies examining distribution of styrene or its metabolites to reproductive organs. One study reported that gavage dosing of rats with 20 mg/kg bw styrene resulted in peak tissue concentrations in 2 hr for most organs.…”

Section: Experimental Animalmentioning

confidence: 99%

“…Two studies examined distribution of styrene to fetuses. Brown (1991) reviewed a Russian-language study of placental styrene transfer. Styrene was measured in maternal and fetal blood and amniotic fluid in rats after inhalation exposure of dams to 3.6 or 10 ppm styrene on gestation day (GD) 18-21.…”

Section: Experimental Animalmentioning

confidence: 99%

“…IARC reports that metabolism of styrene oxide by epoxide hydrolase and glutathione-S-transferase is higher in nasal tissues of rats than mice. Brown (1991) reviewed studies evaluating activity of styrene metabolizing enzymes in reproductive organs. CYP activity was reported to be low in testes and ovaries of rats.…”

Section: Experimental Animalmentioning

confidence: 99%

See 4 more Smart Citations

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

Luderer

Collins

Daston

et al. 2005

Birth Defects Research Pt B

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Section: Experimental Animalmentioning

confidence: 98%

Section: Summary Of General Toxicologymentioning

confidence: 98%

Section: Experimental Animalmentioning

confidence: 99%

Section: Experimental Animalmentioning

confidence: 99%

Section: Experimental Animalmentioning

confidence: 99%

See 3 more Smart Citations

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

Luderer

Collins

Daston

et al. 2005

Birth Defects Research Pt B

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Pregnancy outcome following maternal organic solvent exposure: A meta-analysis of epidemiologic studies

et al. 1998

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Background Evidence of fetal damage or demise from occupational organic solvent levels that are not toxic to the pregnant woman is inconsistent in the medical literature. The risk for major malformations and spontaneous abortion from maternal inhalation of organic solvent exposure during pregnancy was summarized using meta‐analysis. Methods Medline, Toxline, and Dissertation Abstracts databases were searched to locate all research papers published in any language from 1966 to 1994. Included were studies that were case‐control or cohort in design and indicated first trimester (or up to 20 weeks gestation for spontaneous abortion) maternal solvent exposure. A summary odds ratio (ORs) with 95% confidence intervals (CI) was calculated from research results combined by the Mantel‐Haenszel method. Results In total, 559 studies were obtained from the literature search. Five studies for each outcome of interest qualified for inclusion in the analysis. The ORs for major malformations from five studies (n = 7,036 patients) was 1.64 (CI 1.16–2.30) and for spontaneous abortion from five studies (n = 2,899 patients) was 1.25 (CI 0.99–1.58). Conclusions Maternal occupational exposure to organic solvents is associated with a tendency toward an increased risk for spontaneous abortion and additional studies may affect the trend. There is a statistically significant association with major malformations which warrants further investigation. Am. J. Ind. Med. 34:288–292, 1998. © 1998 Wiley‐Liss, Inc.

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Styrene

James

Castor

2000

Ullmann's Encyclopedia of Industrial Chemistry

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Reproductive and developmental toxicity of styrene

Cited by 23 publications

References 80 publications

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene

Pregnancy outcome following maternal organic solvent exposure: A meta-analysis of epidemiologic studies

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