Reproductive and developmental toxicity of inhaled 2,3-dichloro-1,3-butadiene in rats

Mylchreest, Eve; Malley, Linda A.; O'Neill, Arthur J; Kegelman, Thomas; Sykes, Greg P.; Valentine, Raymond C.

doi:10.1016/j.reprotox.2006.04.002

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…FNT significantly decreased epididymis weight but increased testis weight. In this study, the reduction in the weight of reproductive organs, such as the epididymis, could be due to the reduction of androgen availability (23). The increase in the weight of the testes induced by chemicals can be correlated with testicular swelling, followed by atrophy (24).…”

Section: Discussionmentioning

confidence: 89%

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Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats

Taib¹,

Budin²,

Ghazali³

et al. 2013

Clinics

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OBJECTIVE:Fenitrothion residue is found primarily in soil, water and food products and can lead to a variety of toxic effects on the immune, hepatobiliary and hematological systems. However, the effects of fenitrothion on the male reproductive system remain unclear. This study aimed to evaluate the effects of fenitrothion on the sperm and testes of male Sprague-Dawley rats.METHODS:A 20 mg/kg dose of fenitrothion was administered orally by gavages for 28 consecutive days. Blood sample was obtained by cardiac puncture and dissection of the testes and cauda epididymis was performed to obtain sperm. The effects of fenitrothion on the body and organ weight, biochemical and oxidative stress, sperm characteristics, histology and ultrastructural changes in the testes were evaluated.RESULTS:Fenitrothion significantly decreased the body weight gain and weight of the epididymis compared with the control group. Fenitrothion also decreased plasma cholinesterase activity compared with the control group. Fenitrothion altered the sperm characteristics, such as sperm concentration, sperm viability and normal sperm morphology, compared with the control group. Oxidative stress markers, such as malondialdehyde, protein carbonyl, total glutathione and glutathione S-transferase, were significantly increased and superoxide dismutase activity was significantly decreased in the fenitrothion-treated group compared with the control group. The histopathological and ultrastructural examination of the testes of the fenitrothion-treated group revealed alterations corresponding with the biochemical changes compared with the control group.CONCLUSION:A 20 mg/kg dose of fenitrothion caused deleterious effects on the sperm and testes of Sprague-Dawley rats.

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Section: Discussionmentioning

confidence: 89%

“…The reduced weight gained could be attributed to systemic toxicity in male rats (23). FNT significantly decreased epididymis weight but increased testis weight.…”

Section: Discussionmentioning

confidence: 99%

Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats

Taib¹,

Budin²,

Ghazali³

et al. 2013

Clinics

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“…Data were assessed for normality and variance homogeneity by Levene's test. Tests of significance were performed using Dunnett's test after ANOVA analysis (Dunnett, 1980;Mylchreest et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of cloned-cattle meat on reproductive physiology in rats

Hwang

Lee

Hwang³

et al. 2010

Animal

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The influence of the cloned-cattle meat diets upon reproduction in mammals was rarely studied. This study was performed to analyze the effects of the diets containing cloned-cattle (Korean native beef, Hanwoo) meat on the reproductive physiology in rats. The male and female rats were fed with the diets containing 5% or 10% of normal-(N-5 or N-10) or cloned-(C-5 or C-10) cattle meat during test periods. The rats fed with commercial pellets were used as control. Lower food consumption in normaland cloned-cattle meat diet groups is detected in both male and female rats compared with that of control ( P , 0.05, 0.01 and 0.001). No signs of cloned-cattle meat diets on male reproductive parameters are found in all groups, except for lower sperm deformity in C-5 group ( P , 0.05) and higher testosterone concentration in C-10 group ( P , 0.05), respectively. There are no significant test substance-related differences of Caesarean section and delivery in dams and external examination and physiological development test in neonate compared with control and normal meat groups. Based on these results, it can be postulated that there are no obvious negative effects on the reproductive physiology in rats fed with cloned-cattle meat diets compared to their comparators.

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“…Data were tested for normality and homogeneity of variance using Levene's test. Tests of significance were performed using Dunnett's test following an ANOVA analysis (Dunnett, 1980; Mylchreest et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

A diet of somatic cell nuclear transfer cloned‐cattle meat produced no toxic effects on behavioral or reproductive characteristics of F1 rats derived from dams fed on cloned‐cattle meat

Yang

Lee

et al. 2011

Birth Defects Research Pt B

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Reproductive and developmental toxicity of inhaled 2,3-dichloro-1,3-butadiene in rats

Cited by 6 publications

References 20 publications

Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats

Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats

Effects of cloned-cattle meat on reproductive physiology in rats

A diet of somatic cell nuclear transfer cloned‐cattle meat produced no toxic effects on behavioral or reproductive characteristics of F1 rats derived from dams fed on cloned‐cattle meat

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