Reproductive and developmental toxicity of formaldehyde: A systematic review

Duong, Anh Thuy; Steinmaus, Craig; McHale, Cliona M.; Vaughan, Charles P.; Zhang, Luoping

doi:10.1016/j.mrrev.2011.07.003

Cited by 257 publications

(201 citation statements)

References 105 publications

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“…1,6 FA related DNA-protein cross-links, chromosome mutations, sister-chromatid exchanges and micronuclei are considered relevant lesions, 7 but increased production of reactive oxygen species (ROS) and subsequent DNA damage and peroxidation of lipids play a relevant role in FA-induced toxicity. 8 FA causes genetic damage to the nasal tissues of both experimental animals and humans exposed by inhalation. 1 In particular, FA causes the production of malondialdehyde (MDA), or more correctly β-hydroxyacrolein, a reactive lipid peroxidation by-product.…”

Section: Introductionmentioning

confidence: 99%

“…1 In particular, FA causes the production of malondialdehyde (MDA), or more correctly β-hydroxyacrolein, a reactive lipid peroxidation by-product. 8 MDA is an aldehyde capable of interacting with DNA to form 3-(2-deoxy-β-D-erythropentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M 1 dG) adducts. 9,10 Exocyclic M 1 dG adducts, if not repaired, may block cell replication and cause base pair and frameshift mutations in repeated sequences.…”

Section: Introductionmentioning

confidence: 99%

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Formaldehyde-induced toxicity in the nasal epithelia of workers of a plastic laminate plant

et al. 2016

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Formaldehyde is a ubiquitous volatile organic compound widely used for various industrial purposes. Formaldehyde was reclassified by the International Agency for Research on Cancer as a human carcinogen, based on sufficient evidence for a casual role for nasopharyngeal cancer. However, the mechanisms by which this compound causes nasopharyngeal cancer are not completely understood. Therefore, we have examined the formaldehyde-induced toxicity in the nasal epithelia of the workers of a plastic laminate plant in Bra, Cuneo, Piedmont region, North-Western Italy, hence in the target site for formaldehyderelated nasal carcinogenesis. We have conducted a cross-sectional study aimed at comparing the frequency of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M 1 dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in 50 male exposed workers and 45 male controls using 32 P-DNA post-labeling. The personal levels of formaldehyde exposure were analysed by gas-chromatography mass-spectrometry. The smoking status was estimated by measuring the concentrations of urinary cotinine by gas-chromatography mass-spectrometry. The air monitoring results showed that the exposure levels of formaldehyde were significantly greater for the plastic laminate plant workers, 211.4 ± 14.8 standard error (SE) µg m −3 , than controls, 35.2 ± 3.4 (SE) µg m −3 , P < 0.001. The levels of urinary cotinine were 1064 ± 118 ng ml −1 and 14.18 ± 2.5 ng ml −1 in smokers and non-smokers, respectively, P < 0.001. The M 1 dG adduct frequency per 10 8 normal nucleotides was significantly higher among the workers of the plastic laminate plant exposed to formaldehyde, 111.6 ± 14.3 (SE), compared to controls, 49.6 ± 3.4 (SE), P < 0.001. This significant association persisted also when personal dosimeters were used to measure the extent of indoor levels of formaldehyde exposure. No influences of smoking and age were observed across the study population. However, after categorization for occupational exposure, a significant effect was found in the controls, P = 0.018, where the levels of DNA damage were significantly correlated with the levels of urinary cotinine, regression coefficient (β) = 0.494 ± 0.000 (SE), P < 0.002. Our findings indicated that M 1 dG adducts constitute a potential mechanism of formaldehydeinduced toxicity. Persistent DNA damage contributes to the general decline of the physiological mechanisms designed to maintain cellular homeostasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formaldehyde-induced toxicity in the nasal epithelia of workers of a plastic laminate plant

et al. 2016

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“…FA inhibits reproduction in both animals and humans, causing an increase in the incidence of menstrual disorders, inflammatory diseases of the reproductive tract, and sterility, and increased risk of spontaneous abortion and adverse developmental effects during pregnancy, such as low birth weights among offspring (Duong et al, 2011;TOXNET Database). It is categorized as a known human carcinogen by the International Agency for Research on Cancer (IARC).…”

Section: Toxicity and Ecotoxicity Of Selected Adhesive Components Toxmentioning

confidence: 99%

Adhesives based on formaldehyde – environmental problems

Wojtkowska¹,

Załęska-Radziwiłł²,

Tabernacka³

2017

bta

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Adhesives are substances that increase the surface adhesion of bonded items. Unfortunately, they also emit volatile organic compounds (VOCs) which negatively impact upon human and animal health. VOCs have carcinogenic and mutagenic properties and can cause migraines, irritation to the eyes, nasal passages, mouth, and lungs, and respiratory problems. Wastewater from adhesive production is characterized by high levels of pollutants and contains high concentrations of compounds including formaldehyde that are toxic to water biocenoses. Moreover, its purification causes many problems and requires the application of specific methods. This review presents data concerning the toxicity and ecotoxicity of selected adhesives components. VOC emission rates from adhesives and wooden construction elements with adhesives are also discussed and assessed. Current knowledge on the treatment methods for wastewater containing adhesive components is reviewed. Finally, the treatment and disposal methods for solid wooden waste containing adhesives are also analyzed and discussed.

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“…Outros estudos também apontam que a exposição constante a formaldeído influencia de forma negativa o sistema hormonal e a reprodução humana. 4 Baseados nos estudos toxicológicos do formol, o órgão responsável pelo controle de produtos no Brasil, a ANVISA (Agência Nacional de Vigilância Sanitária), proibiu a comercialização do formol e restringiu sua utilização em alguns produtos cosméticos (Resolução-RDC nº 35, publicada em 3 de junho de 2008; e Resolução-RDC nº 36, publicada em 17 de junho de 2009). A proibição do formol e sua restrição também ocorrem em outros países, como, entre outros, os Estados Unidos, Inglaterra, Alemanha e Japão.…”

Section: Introductionunclassified