Reproductive Development and Functions in the Rat after Repeated Maternal Deprivation Stress

Lau, Christopher; Klinefelter, Gary R.; Cameron, Annie M.

doi:10.1093/toxsci/30.2.298

Cited by 12 publications

(4 citation statements)

References 21 publications

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“…Here, we demonstrate that (1) the rats continue their respective individual cycles throughout the experiment and (2) the rats within as well as between each experimental group are in separate individual cycles. This is in accord with the findings of Lau et al (1996) and also shows that the maternal separation-induced effects on ethanol intake presented herein were not secondary to a hormonal influence. In our previous experiments, using the same experimental protocol, no differences in body weight have been found between the groups during the period of access to ethanol (Gustafsson et al, 2005;Ploj et al, 2003a;Roman et al, 2003Roman et al, , 2004).…”

Section: Figsupporting

confidence: 93%

Short and Prolonged Periods of Maternal Separation and Voluntary Ethanol Intake in Male and Female Ethanol-Preferring AA and Ethanol-Avoiding ANA Rats

Roman

Gustafsson²,

Hyytiä³

et al. 2005

Alcoholism: Clinical & Experimental Research

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Section: Figsupporting

confidence: 93%

Short and Prolonged Periods of Maternal Separation and Voluntary Ethanol Intake in Male and Female Ethanol-Preferring AA and Ethanol-Avoiding ANA Rats

Roman

Gustafsson²,

Hyytiä³

et al. 2005

Alcoholism: Clinical & Experimental Research

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“…This delay may also be seen following metabolic stress, as forced fasting is a well-known model of pubertal delay in rats [77]. However, some potent stressors, like maternal separation, do fail to induce changes in pubertal onset [78, 79]. Furthermore, some stressors have been associated with precocious pubertal onset in rodents.…”

Section: Impact Of Stress On the Hpg Axis: Role Of Gabaarsmentioning

confidence: 99%

GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function

Melón

Maguire

2016

The Journal of Steroid Biochemistry and Molecular Biology

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The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are regulated by GABAergic signaling at the level of corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GnRH) neurons, respectively. Under basal conditions, activity of CRH and GnRH neurons are controlled in part by both phasic and tonic GABAergic inhibition, mediated by synaptic and extrasynaptic GABAA receptors (GABAARs), respectively. For CRH neurons, this tonic GABAergic inhibition is mediated by extrasynaptic, δ subunit-containing GABAARs. Similarly, a THIP-sensitive tonic GABAergic current has been shown to regulate GnRH neurons, suggesting a role for δ subunit-containing GABAARs; however, this remains to be explicitly demonstrated. GABAARs incorporating the δ subunit confer neurosteroid sensitivity, suggesting a potential role for neurosteroid modulation in the regulation of the HPA and HPG axes. Thus, stress-derived neurosteroids may contribute to the impact of stress on reproductive function. Interestingly, excitatory actions of GABA have been demonstrated in both CRH neurons at the apex of control of the HPA axis and in GnRH neurons which mediate the HPG axis, adding to the complexity for the role of GABAergic signaling in the regulation of these systems. Here we review the effects that stress has on GnRH neurons and HPG axis function alongside evidence supporting GABAARs as a major interface between the stress and reproductive axes.

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“…One of the shared risk factors for both psychopathology and deviations in pubertal timing is exposure to early‐life stress. A number of studies have shown that stress accelerates pubertal development in girls, as well as in female rodents (Belsky et al, ; Li et al, ; Semiz, Kurt, Kurt, Zencir, & Sevinç, ; Tremblay & Frigon, ; but see also Lau, Klinefelter, & Cameron, ). For example, there is a particularly strong association between childhood sexual abuse and early menarche (Boynton‐Jarrett et al, ; Mendle, Leve, Van Ryzin, Natsuaki, & Ge, ; Mendle, Ryan, & McKone, ), but precocious puberty onset has also been observed in females exposed to less extreme cases of stress, such as low socioeconomic status or low levels of maternal care (Borrow, Levy, Soehngen, & Cameron, ; Cameron et al, ; James‐Todd, Tehranifar, Rich‐Edwards, Titievsky, & Terry, ).…”

Section: Introductionmentioning

confidence: 99%

Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation

Cowan

Richardson

2018

Developmental Psychobiology

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Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress.

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Reproductive Development and Functions in the Rat after Repeated Maternal Deprivation Stress

Cited by 12 publications

References 21 publications

Short and Prolonged Periods of Maternal Separation and Voluntary Ethanol Intake in Male and Female Ethanol-Preferring AA and Ethanol-Avoiding ANA Rats

Short and Prolonged Periods of Maternal Separation and Voluntary Ethanol Intake in Male and Female Ethanol-Preferring AA and Ethanol-Avoiding ANA Rats

GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function

Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation

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