Reproductive Development of the Christmas Rose (Helleborus niger L.): The Role of Plant Hormones

Salopek‐Sondi, Branka

doi:10.5562/cca1820

Cited by 6 publications

(6 citation statements)

References 53 publications

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“…In Transylvanian ethnoveterinary medicine, local use of H. purpurascens root was documented in immunotherapy, as in earlier works from Romania (Sadler 1824;Bogdan et al 1990), Italy (Pieroni et al 2004), and Hungary (Kóczián 2014). Similar use of H. odorus was documented in Italy (Cornara et al 2009;Manganelli et al 2001), and that of H. dumetorum Waldst.…”

Section: Discussionmentioning

confidence: 80%

“…In the last century and currently, the pungent and bitter root and rhizome (Sadler 1824;Borza 1968) have been widely used as aspecific immunostimulant drugs in the European ethnoveterinary medicine: they have been applied for pneumonia and cough of pigs, cows, and horses (Kóczián et al 1975(Kóczián et al , 1976Halászné 1981Halászné , 1987Péntek and Szabó 1985;Gub 1993Gub , 1996Gub , 2000Bárdi et al 2002;Pieroni et al 2004;Szabó 2005;Babai 2013), against nasal congestion of horses (Pieroni et al 2013), for helminthiasis (Butura 1979), and cooked and blended with fat against lice of animals (Gub 1993). The leaf has been known for rheuma as a foment (Halászné 1981(Halászné , 1987, and soaked into the fodder of pigs against pneumonia and cough (Kóczián et al 1976).…”

Section: Introductionmentioning

confidence: 99%

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Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Balázs

Filep

Ambrus

et al. 2020

Genet Resour Crop Evol

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The use of hellebore (Helleborus) species for medical purposes has a long-standing tradition. Our work aimed at providing a historical survey of their medicinal application in Europe, and data on current ethnobotanical use of H. purpurascens Waldst. et Kit. in Transylvania (Romania), compared with earlier records of this region and other European countries. While the chemistry and pharmacology of hellebores have been researched extensively, little is known about their anatomical traits. Thus, we intended to provide a detailed histological analysis of Helleborus odorus Waldst. et Kit., H. purpurascens, and H. niger L., based on transverse sections of aerial parts and root. Our survey revealed that H. purpurascens is known for immunotherapy, wounds, and as antiemetic drug in ethnoveterinary medicine, but not in human therapy in the study area. Distinctive histological characters included diverse stele structure in the root; sclerenchymatous bundle caps around compound vascular bundles in the stem and the main leaf veins of H. odorus; and amphistomatic leaves in H. purpurascens. Quantitative vegetative traits also revealed significant differences among species, but they may reflect environmental influences, too. In all three species the sepal was hypostomatic with mesomorphic stomata, while the modified petal comprised a proximal nectar-producing and a distal non-secretory part. Distinctive floral traits included shape of modified petal, presence of papillae and thickness of nonsecretory part; as well as ornamentation of tricolpate pollen grains. Our findings suggest that the anatomy of various plant parts varies slightly with each species, including ethnomedicinally known H. purpurascens, even though the basic structure is the same within the genus.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Balázs

Filep

Ambrus

et al. 2020

Genet Resour Crop Evol

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“…4 In view of the reproductive development of H niger, the role of its plant hormones has also been described. 5 A detailed historical overview of the long tradition from antiquity to the present of H niger in folk medicine, together with the related species H purpurascens Waldst. & Kit.…”

Section: Introductionmentioning

confidence: 99%

“…4 In view of the reproductive development of H niger , the role of its plant hormones has also been described. 5…”

Section: Introductionmentioning

confidence: 99%

Bioactive Ingredients of Helleborus niger L. (Christmas Rose): The Renaissance of an Old Medicinal Herb—A Review

Cuny

2023

Natural Product Communications

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The medicinal plant Helleborus nig er L. (Ranunculaceae) found in the European Alps has been valued as an effective remedy for numerous diseases for centuries. Recent preclinical evaluations showed pharmacologic potential of the plant extract for cancer treatment. Furthermore, several compounds extracted from H niger exhibited potent pharmacological effects. Thus, the renaissance of this old and proven medicinal herb requires better knowledge of its bioactive ingredients. A key ingredient of H niger is protoanemonin which is responsible for its burning hot taste and vesicant effect. Protoanemonin possesses antibacterial, antifungal, cytotoxic, and antimutagenic activity, and its isolation, synthesis, and preparation as a therapeutically valuable medicinal product are well elaborated. Anemonin, the dimer of protoanemonin, has antimicrobial, anti-inflammatory, and antimalarial activity, whereas (−)-ranunculin, a protoanemonin glycoside, possesses cytotoxicity and antimutagenic activity. (+)-Ranuncoside, another protoanemonin glycoside, has a spiro acetal molecular scaffold, a feature that is responsible for the biological activity of a multitude of natural products. Furthermore, the flavonoids kaempferol glycoside, quercetin glycoside, and glucosyl-phenyllactic acid have been isolated, and other phenolics with complex structures were detected as well. The main active ingredient of H niger rhizomes is the bufadienolide hellebrin. It is a steroidal cardiac diglycoside with utility for heart failure treatment. Hellebrin and its aglycon hellebrigenin are patented as lead compounds to treat cancer. Recently, additional bufadienolides as well as ecdysteroids were isolated from H niger whole plants and showed potent cytotoxicity on human cancer cell lines. Finally, various saponins have been determined by mass spectrometry, of which 4 compounds isolated from the rhizome are awaiting pharmacological assessment. This review gives an overview of the current knowledge of the isolation, synthesis, structure elucidation, derivatization, and biological activities of known H niger constituents. Furthermore, recent advances concerning the development of pharmaceuticals from these constituents and their derivatives are described.

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“…& Kitt., a deciduous species with green flowers [ 21 , 22 ]. After pollination during fruit development, H. niger sepals also turn green and become photosynthetically active [ 23 ]. Both species develop flowers during late winter and early spring.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Temporal Changes in Pigments and Optical Properties in Sepals of Helleborus odorus and H. niger from Prebloom to Seed Production

Grašič

Dacar

Gaberščik

2021

Plants

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Helleborus niger is an evergreen species, while H. odorus is an herbaceous understorey species. They both develop flowers before the forest canopy layer closes. Their sepals remain after flowering and have multiple biological functions. To further elucidate the functions of sepals during flower development, we examined their optical and chemical properties, and the photochemical efficiency of photosystem II in the developing, flowering, and fruiting flowers. Sepals of the two species differed significantly in the contents of photosynthetic pigments and anthocyanins, but less in the UV-absorbing substances’ contents. Significant differences in photosynthetic pigment contents were also revealed within different developmental phases. The sepal potential photochemical efficiency of photosystem II was high in all developmental phases in H. odorus, whereas in H. niger, it was initially low and later increased. In the green H. odorus sepals, we obtained typical green leaf spectra with peaks in the green and NIR regions, and a low reflectance and transmittance in the UV region. On the other hand, in the white H. niger sepals in the developing and flowering phases, the response was relatively constant along the visible and NIR regions. Pigment profiles, especially chlorophylls, were shown to be important in shaping sepal optical properties, which confirms their role in light harvesting. All significant parameters together accounted for 44% and 34% of the reflectance and transmittance spectra variability, respectively. These results may contribute to the selection of Helleborus species and to a greater understanding of the ecological diversity of understorey plants in the forests.

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Reproductive Development of the Christmas Rose (Helleborus niger L.): The Role of Plant Hormones

Cited by 6 publications

References 53 publications

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Bioactive Ingredients of Helleborus niger L. (Christmas Rose): The Renaissance of an Old Medicinal Herb—A Review

Comparative Study of Temporal Changes in Pigments and Optical Properties in Sepals of Helleborus odorus and H. niger from Prebloom to Seed Production

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