Reproductive dysfunctions in viral hepatitis

Kurmanova, Almagul; Kurmanova, Gaukhar; Локшин, В. Н.

doi:10.1080/09513590.2016.1232780

Cited by 29 publications

(24 citation statements)

References 10 publications

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“…As is well known, there are many forms of viruses affecting the female reproductive endocrine system. For example, menstrual disorders are prevalent in women with HBV or HCV infections, and reproductive dysfunction in the form of pregnancy loss and infertility have also been detected( Kurmanova, 2016 ). An earlier age of onset of menopause was found in women with HIV( Nanette, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one study reported that the cellular immune response plays a significant role during HBV and HCV infections, which may result in abnormal ovarian function( Kurmanova, 2016 ). In addition, the treatment process affects the female hypothalamic-gonadal-axis( Kao, et al, 2019 ).The glucocorticoids treatments might be used in some cases, and their effect on the reproductive and endocrine system in women of child-bearing age is not yet known.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age

Chen

Hou

et al. 2021

Reproductive BioMedicine Online

270

259

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Research question Whether SARS-CoV-2 infection has effects on ovarian reserve, sex hormone and menstruation of women of child-bearing age. Design This is a retrospective, cross-sectional study. Clinical and laboratory data from 237 women of child-bearing age diagnosed with COVID-19 were retrospectively reviewed. Menstrual data from 177 patients were analyzed. Blood samples from the early follicular phase were tested for sex hormones and Anti-mullerian hormone (AMH). Results Among 237 patients confirmed with COVID-19, severely ill patients had more comorbidities than mildly ill patients (34% vs 8%), especially for patients with diabetes, hepatic disease and malignant tumors. Among 177 patients with menstrual records, 45 (25%) patients presented with menstrual volume changes, and 50 (28%) patients had menstrual cycle changes, mainly a decreased volume (21%) and a prolonged cycle (19%). The average sex hormone and AMH levels of women of child-bearing age with COVID-19 were not different from those of age-matched controls. Conclusions Average sex hormone levels and ovarian reserve did not change significantly in COVID-19 women of child-bearing age. Nearly one-fifth of patients exhibited a menstrual volume decrease or cycle prolongation. The menstruation changes of these patients might be the consequence of transient sex hormone change cause by suppression of ovarian function that soon resumed after recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age

Chen

Hou

et al. 2021

Reproductive BioMedicine Online

270

259

View full text Add to dashboard Cite

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“…Cryoglobulinemia is an autoimmune manifestation most commonly identified among patients with hepatitis C virus infection. Purpura, arth ralgia, fatigue, myalgia, polyneuropathy, glomerulonephritis, ophthalmopathy, and intestinal ischemia are the major clinical symptoms [88,18]. A large variety of clinical characteristics are present in patients with cryoglobulinemia and are discussed as follows:…”

Section: Hcv-related Cryoglobulinemic Vasculitis Manifestationmentioning

confidence: 99%

“…It should be remembered that generalized vascular disease triggers reproductive function disorders in hepatitis B virus and hepatitis C virus infections. With the successive development of hormonal homeo stasis dysfunction, immune complex vascu litis produces degenerative changes in the hypothalamic pituitary area [88].…”

Section: Female Reproductive Dysfunctionsmentioning

confidence: 99%

HCV-Related Vasculitis

Gauhar

Shafiq

Kurmanova

et al. 2021

IAM

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Up to 3% of people in the world are infected with HCV, and 75-80% of them have chronic currency of infection. In the clinical picture of HCV infection, a significant place is given to extrahepatic manifestations -more than half of patients suffer from lesions of the skin, kidneys, heart, blood vessels, autoimmune and lymphoproliferative syndromes associated with HCV. Usually, mortality from chronic hepatitis C is associated with liver cirrhosis and hepatocellular carcinoma, but in fact, more patients die from complications associated with the development of cryoglobulinemic vasculitis -chronic renal failure and cardiovascular catastrophes. 40-60% of patients with chronic HCV infection suffer from cryoglobulinemic vasculitis in a wide range of clinical manifestations: from minimal to life-threatening. The pathogenesis of mixed cryoglobulinemia syndrome is based on polyclonal activation of lymphocytes.The systemic nature of the lesion, which is observed in HCV infection, reflects its generalized nature with the involvement of many organs and tissues in the pathological process, which complicates timely diagnosis and treatment. A variety of systemic extrahepatic pathology, which often outstrips the clinical picture of hepatitis itself, masquerading as another disease means that a specialist of any profile can meet with chronic HCV infection and its consequences.

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“…Early intrauterine infection by HBV, herpes simplex virus (HSV) and human cytomegalovirus (HCMV) could cause abnormal embryo development, early abortion, stillbirth or fetal malformation [3][4][5][6] . In our previous study, HBV mRNA was detected in discarded human embryos, and abortion occurred in these patients in the later follow-up [7] .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of the Effect of HBV Infection on Early Embryonic Development

Feng

Cui

Kong

et al. 2021

Preprint

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Objective: This study aimed to clarify the infection state of early embryos by HBV and the effect of HBV infection on embryo development. Methods: In vitro culture was carried out on the fresh surplus embryos from infertile couples on the third day (D3) who received routine in vitro fertilization and embryo transfer (IVF-ET) treatment. The embryo cells were infected in vitro by the serum of HBV infected patients with different viral loads. HBsAg quantity in the supernatant secreted by embryo and HBV mRNA in embryo cells were detected. The development of embryo cells after HBV infection was evaluated by embryo morphological parameter score and fragment score in embryo cells. Results: From May 2013 to July 2015, 238 cases of D3 fresh surplus embryos from 120 infertile couples and 128 samples of embryo culture supernatant were collected. The HBsAg positive rate in the supernatant of embryos in the high viral load infection group was significantly higher than that in the low viral load infection group (40.0% vs.15.6%, p<0.05). HBV mRNA was detected in 2 of 17 HBsAg positive embryos. The scores of embryos in the high load HBV culture solution group were higher than those in the low load group (p=0.04). There was one formed blastocyst in low load HBV culture group, but there was no blastocyst formation in all embryo cells of high load group (p<0.001).Conclusion: The results suggest that embryo cells can be directly infected by HBV in vitro. HBV infection affects the development of embryos.

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Reproductive dysfunctions in viral hepatitis

Cited by 29 publications

References 10 publications

Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age

Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age

HCV-Related Vasculitis

In Vitro Study of the Effect of HBV Infection on Early Embryonic Development

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