Reproductive effects of sulfoxaflor in male Sprague Dawley rats

Mohamed, Wafaa H.; Ali, Marwa F.; Yahia, Doha; Hussein, Hassan A.

doi:10.1007/s11356-022-19006-3

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…Mahgoub and El-Medany [14] also indicated that malathion caused a decrease in sperm count. As well, Mohamed et al [15] found that physiological changes, including necrosis and degeneration in the epithelial tissue of the rat testes, occurred in the male organs of the rat during exposure to the pesticide sulfoxaflor.…”

Section: Introductionmentioning

confidence: 93%

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Ali¹,

Zain²

2023

IJDNE

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Agricultural pesticides play an important and pivotal role in agricultural production processes in all their stages, and the superior success shown by agricultural pesticides in controlling agricultural pests has led to greater dependence on them. Pesticides accumulate in the food chain and the human environment over time in both cases, including the overuse or misuse of many of them in various fields at times. However, they are also used to treat agricultural biting and sucking insects. The current paper aims to investigate the effect of a sub lethal dose of pyrethiored insecticide on the hepatocytes of male albino mice. Based on the current results, the hepatocyte structure and tissues section clarify the effect of Permethrin insecticide, including changes such as necrosis, venous hypertrophy, and increased vacuoles. The hepatic portal and vacuoles show vacuolar degeneration, which means that the changes are severe and an indication of the toxicity of insecticide, and this difference appears to be significant compared to the control.

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Section: Introductionmentioning

confidence: 93%

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Ali¹,

Zain²

2023

IJDNE

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“…Pesticides are one of the most detrimental chemicals liberated in the environment in an unplanned manner [1]. They have negative effects on animals and humans [2]. These effects may occur directly through bioaccumulation or indirectly via the food chain.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dimethoate Insecticide on Female Mice and Their Fetuses

Sasi,

Alghoul,

Mohamed

et al. 2024

KJDMR

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Background and objectives. Organophosphate insecticides (OPIs) including dimethoate are used in agriculture to control the insect pests, increasing the productivity, their frequent use has resulted in detrimental effects on biological systems and public health. This study aimed to evaluate the effect of dimethoate (DM) on fetuses, DNA concentration in ovarian tissues and levels of estradiol and progesterone in female mice. Methods. Female mice were divided into three groups: Group I, serve as control and was given distilled water intraperitoneally, while Group II and III were given (0.1- & 0.2-ml DM/100 ml distilled water) respectively for 7 days. Two treated females were housed with one untreated male for mating. After 7 days of the last dose, 6 female mice of each group were weighed and killed. The ovaries, uteri and liver were extracted and weighed, and ovarian hormones were measured. Also, DNA concentration in each ovary was determined. Results. The results showed a significant decrease in the weights of the liver and ovaries, the level of estradiol hormone, and DNA concentration in the ovary of treated mice as compared to those from the control group. Also, significant changes were observed in the weights of fetuses as well as the number of live fetuses. Conclusion. We found that administration of DM intraperitoneally to female mice for 7 days has influences on ovary weight, estradiol levels, and DNA concentration as well as its impact on the fetuses, therefore, it is better to use safer methods for control the pests and avoid increased use of pesticides.

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Thiacloprid impairs reproductive functions of male Wistar rats

Mahmoud,

Ahmed,

Omar

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Global male infertility correlated to the rise of endocrine-disrupting chemicals, including insecticides, has grown into a pressing problem. Thiacloprid is one of the most commonly used neonicotinoids that accounts for more than 25% of the global pesticide industry. However, its impact on the reproductive system and male fertility has not been fully elucidated. The object of this study was to explore the adverse effects of thiacloprid on male Wistar rats’ reproductive system. Thirty healthy male rats were separated into one of three groups: control group, and two groups that were orally administered with low (22.5 mg/kg) and high dose (62.1 mg/kg) of thiacloprid for 56 days. Thiacloprid significantly (p<0.05) reduced body weight and relative testicular weight, as well as sperm quality (count, motility, viability, and morphology), in a dose-dependent manner. THIA-treated groups revealed a large effect (d > 0.8) on semen quality with Cohen’s d of (6.57, 8.82), (20.14, 23.54), and (2.81, 9.10) for count, motility, and viability respectively. Meanwhile, the serum testosterone level dropped while the levels of luteinizing and follicle-stimulating hormones increased. 17ꞵ-hydroxy steroid dehydrogenase and 3ꞵ-hydroxy steroid dehydrogenase levels were significantly decreased in a dose-dependent manner. The activity of the tested antioxidant enzymes catalase (CAT), glutathione reduced (GSH), and superoxide dismutase (SOD) exhibited a considerable decrease compared to the control group with a significant elevation in the lipid peroxidation activity as indicated by malondialdehyde (MDA) level. The testicular histology revealed degenerative changes in spermatogenic cells and interstitial tissue. Comet assay revealed DNA fragmentation in treated groups’ testicular tissue. Thiacloprid exposure interferes with reproductive function and impairs male Wistar rat fertility. Such harmful consequences may also develop in humans frequently exposed to thiacloprid.

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Reproductive effects of sulfoxaflor in male Sprague Dawley rats

Cited by 5 publications

References 40 publications

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Effect of Sub Lethal Dose of Pyrethroids Insecticide on Hepatocyte of Female Albino Mice

Effect of Dimethoate Insecticide on Female Mice and Their Fetuses

Thiacloprid impairs reproductive functions of male Wistar rats

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