Reproductive Factors, Subfertility, and Risk of Neural Tube Defects: A Case-Control Study Based on the Oxford Record Linkage Study Register

Neural tube defects are serious birth defects of the brain and the spinal cord due to interference with neural tube closure about the 28th day after fertilization. Seasonal variation in the development of neural tube defects has been reported. The objective of this study was to demonstrate any association between the season of conception and the development of neural tube defects in the north of Jordan. For a 7-year period between January 2000 and December 2006, data of 78 neonates born with neural tube defect were analyzed regarding dates of conception in relation to the development of neural tube defects. More affected babies were conceived in the late summer and early autumn. The study demonstrated that seasonality affected the incidence of neural tube defects in the north of Jordan.

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“…10,13 This pattern was not reflected in the data of this study, as only 1 of 78 affected babies was a twin.…”

contrasting

confidence: 61%

Neural Tube Defects in the North of Jordan: Is There a Seasonal Variation?

Obeidat

Amarin

2009

J Child Neurol

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“…Whiteman et al . [15] in their study of 694 cases of NTD in Oxfordshire, England also found that female offspring were more than twice as likely as males to harbor an NTD.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of the neural tube defects in Kashmir Valley

et al. 2016

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Introduction/Background:Neural tube defects (NTD) are the most common congenital malformations affecting the brain and spinal cord and have a multifactorial etiology. Genetic and environmental factors have been found to cause these defects, both individually and in combination.Aims and Objectives:The aim of this study was to determine the incidence, types, demographics, risk factors, and other associated anomalies relevant to NTDs in Kashmir Valley.Materials and Methods:A 2-year hospital-based prospective study was carried out from November 2013 to October 2015. A detailed history of the mother was taken along with detailed clinical examination of neonate including measurement of head circumference and checking the status of fontanella, whether - lax/full/bulging/or tense, type of NTD. Investigations that were done included were X-ray skull: Anteroposterior (AP) and lateral, X-ray spine: AP and lateral, ultrasonography abdomen, magnetic resonance imaging: Spine and brain.Results:The total number of babies with NTD's was 125 with an overall incidence of 0.503. District Kupwara was having the highest incidence (1.047) and district Srinagar the lowest incidence of NTD's (0.197). The majority of NTD's (116 cases, 92.8%) were found in the rural areas. Among the different types of NTD's, spina bifida had an incidence of 0.342 (85 cases, 68%), and anencephaly had an incidence of 0.113 (28 cases, 22.4%). There was a slight preponderance of females over males with NTD's. There were70 females (56%) and 55 males (44%) respectively with a male:female ratio of 0.8:1.Conclusions:The incidence rates of NTDs are very high for Kashmir Valley. Geographical distribution of NTDs at this place confirms a relationship between the socioeconomic status, educational status, maternal age and environmental factors for the development of an NTD. The results of this study point to the importance establishing a health policy to prevent NTDs in Kashmir Valley.

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“…The technical issues of record linkage (particularly the challenges of working with measurement error and marginal information) have been explored in depth elsewhere (Fellegi and Sunter 1969;Newcombe 1988). Record linkage has received considerable attention in epidemiology and health services research, facilitating studies of many types in several different countries (Howe 1998;Whiteman et al 2000).…”

Section: Sas Macrosmentioning

confidence: 99%

Working More Productively: Tools for Administrative Data

Roos

Soodeen²,

Bond³

et al. 2003

Health Services Research

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Objective. This paper describes a web‐based resource (http://www.umanitoba.ca/centres/mchp/concept/) that contains a series of tools for working with administrative data. This work in knowledge management represents an effort to document, find, and transfer concepts and techniques, both within the local research group and to a more broadly defined user community. Concepts and associated computer programs are made as “modular” as possible to facilitate easy transfer from one project to another. Study Setting/Data Sources. Tools to work with a registry, longitudinal administrative data, and special files (survey and clinical) from the Province of Manitoba, Canada in the 1990–2003 period. Data Collection. Literature review and analyses of web site utilization were used to generate the findings. Principal Findings. The Internet‐based Concept Dictionary and SAS macros developed in Manitoba are being used in a growing number of research centers. Nearly 32,000 hits from more than 10,200 hosts in a recent month demonstrate broad interest in the Concept Dictionary. Conclusions. The tools, taken together, make up a knowledge repository and research production system that aid local work and have great potential internationally. Modular software provides considerable efficiency. The merging of documentation and researcher‐to‐researcher dissemination keeps costs manageable.

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Reproductive Factors, Subfertility, and Risk of Neural Tube Defects: A Case-Control Study Based on the Oxford Record Linkage Study Register

Cited by 61 publications

References 18 publications

Neural Tube Defects in the North of Jordan: Is There a Seasonal Variation?

Neural Tube Defects in the North of Jordan: Is There a Seasonal Variation?

Epidemiology of the neural tube defects in Kashmir Valley

Working More Productively: Tools for Administrative Data

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