Reproductive Function in the Genetically Obese “Fatty” Rat

Saiduddin, Syed; Bray, George A.; York, David A.; SWERDLOFFf, Ronald S.

doi:10.1210/endo-93-6-1251

Cited by 67 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fatty females were also demonstrated to have delayed vaginal opening, prolonged estrous cycle, and decreased uterine weight. These findings are consistent with decreased estrogen secretion and/or impaired estrogen effects [14,15]. Leydig cells of male Zucker rats contain numerous fat droplets and few signs of active hormone synthesis; the serum testosterone concentrations are lower in fatty males than in their homozygous controls [16].…”

Section: Introductionsupporting

confidence: 66%

Isoflavone Consumption Does Not Increase the Bone Mass in Osteopenic Obese Female Zucker Rats

Picherit¹,

Horcajada²,

Mathey³

et al. 2003

Ann Nutr Metab

View full text Add to dashboard Cite

Some controversy exists in the literature concerning the effects of leptin on bone metabolism. Thus we have compared femoral bone density and biochemical markers of bone metabolism in male and female fatty (leptin-resistant) Zucker rats and their lean homozygous controls at 3 and 6 months of age. At 3 months, no differences concerning total, diaphyseal (cortical bone), and distal metaphyseal (trabecular bone) femoral bone densities, plasma osteocalcin concentrations, and urinary deoxypyridinoline excretion were observed between fatty and lean rats. On the opposite, at 6 months of age, in both males and females, total, diaphyseal, and distal metaphyseal femoral bone densities and plasma osteocalcin concentrations were lower in Zucker than in lean rats. Soybean isoflavone consumption (40 µg/g body weight/day for 90 days, a dose which prevents osteopenia following ovariectomy both in lean Zucker homozygous controls and in Wistar rats) by obese female Zucker rats had no significant effect upon their bone mass.

show abstract

Section: Introductionsupporting

confidence: 66%

Isoflavone Consumption Does Not Increase the Bone Mass in Osteopenic Obese Female Zucker Rats

Picherit¹,

Horcajada²,

Mathey³

et al. 2003

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…fa/fa zucker rats also show delayed vaginal opening, subsequent abnormal estrous cyclicity, undeveloped uteri and lack of deciduomata formation (Saiduddin et al, 1973) as well as These facts suggest that young fa/fa zucker rats may have disadvantage as a mammary carcinogenesis model in aspect s of abnormal development of mammary glands and hormone environment. Therefore, the model in which the level of leptin can be effectively controlled by some exogenous factor such as diet might be a better one.…”

Section: Discussionmentioning

confidence: 89%

Female heterozygous (+/<i>fa</i>) Zucker rats as a novel leptin-related mammary carcinogenesis model

et al. 2012

View full text Add to dashboard Cite

-The homozygous mutant fatty Zucker rat (fa/fa) is the prominent model for the research of obesity, one of the most well-known risk factor of postmenopausal mammary cancer. But the usage as a mammary gland carcinogenesis model is considered to be restricted due to the hypoplasia of mammary gland. In the present study, to find the validity of heterozygous mutant (+/fa) lean Zucker rats as a new leptin-related mammary carcinogenesis model, we examined whether the number of terminal end buds of mammary gland, the serum biochemistry, leptin concentration in serum and adipose tissue are changed in 7-week-old female +/+, +/fa and fa/fa rats, and whether these changes and leptin, TNF-α and VEGF mRNA expression in adipose tissue of +/+ and +/fa rats are influenced by 10% corn oil diet for 5 weeks. We confirmed that mild hyperleptinemia was more pronounced in 7-week-old +/fa as compared with wild type (+/+) and hypoplasia of mammary glands characterized by fewer numbers of terminal end buds in fa/fa was not observed in +/fa. With 10% corn oil diet, leptin mRNA expression in adipose tissue showed increasing tendency both in +/fa and +/+. Comparing with +/+, adipose tissue in +/fa treated with 10% corn oil diet was found to be significantly increased in the concentration of leptin protein and tended to be elevated expression of TNF-α mRNA. These results suggest that +/fa with 10% corn oil diet may be a useful model for investigation of the participation of leptin and TNF-α in mammary gland carcinogenesis.

show abstract

“…Reproductive abnormalities causing sterility in obese female rats may include imbalances in estrogen secretion (Whitaker et al, 1983), reduced weight of the uteri and prolonged estrous cycles (Saiduddin et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

The First Documentation of Reproduction in a Genetically Obese Female fa/cp Rat

Kahle¹,

Butz²,

Michaelis³

et al. 1994

ILAR Journal

View full text Add to dashboard Cite

would like to see their future children protected from dread genetic disorders to eugenics, which would involve socially mandated genetic engineering of children. The only way to avoid this moral slide is to forbid the development of the technology from the beginning.In the final analysis I find all of these objections less than compelling because there are competing moral considerations that weaken their moral force. I conclude that germline genetic engineering should go forward, though we may discover as the technology unfolds that there are specific applications of it that are morally objectionable. Animal Models

show abstract

Reproductive Function in the Genetically Obese “Fatty” Rat

Cited by 67 publications

References 0 publications

Isoflavone Consumption Does Not Increase the Bone Mass in Osteopenic Obese Female Zucker Rats

Isoflavone Consumption Does Not Increase the Bone Mass in Osteopenic Obese Female Zucker Rats

Female heterozygous (+/<i>fa</i>) Zucker rats as a novel leptin-related mammary carcinogenesis model

The First Documentation of Reproduction in a Genetically Obese Female fa/cp Rat

Contact Info

Product

Resources

About