Reproductive hormonal profiles of endurance-trained and untrained males

Hackney, Anthony C.; Sinning, W. E.; Bruot, Brent C.

doi:10.1249/00005768-198802000-00009

Cited by 201 publications

(152 citation statements)

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“…Low serum FSH, LH, and T values indicate hypothalamo-pituitary disease, i.e., hypogonadotropic hypogonadism. Lower basal levels of Tor fT have also been reported in endurance-trained individuals in previous studies (Cooper et al 1998, Hackney et al 1998. In another study, 20 male marathon athletes were evaluated by hormonal profiles, psychological testing, anthropomorphic indices, and semen evaluations by Ayers et al (1985).…”

Section: Discussionmentioning

confidence: 71%

The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study

Safarinejad¹,

Azma²,

Kolahi³

2008

Journal of Endocrinology

137

112

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Effects of intensive exercise on hypothalamus-pituitary-testis (HPT) axis remain controversial. Our aim was to determine the effects of intensive, long-term treadmill running on reproductive hormones, HPT axis, and semen quality. A total of 286 subjects were randomly assigned to moderate-intensity exercise (w60% maximal oxygen uptake (VO 2max ); group 1, nZ143) and high-intensity exercise (w80% VO 2max ; group 2, nZ143) groups. The two groups exercised for 60 weeks in five sessions per week, each session lasting 120 min. This was followed by a 36-week low-intensity exercise recovery period. All subjects underwent routine semen analysis. Blood samples were drawn for the determination of the levels of the following hormones: LH, FSH, prolactin, testosterone (T), free testosterone (fT), inhibin B, and sex hormone-binding globulin (SHBG). The HPT axis was assessed using GnRH and human chorionic gonadotropin tests. After 24 weeks of exercise, the subjects exercising with high intensity demonstrated significantly declined semen parameters compared with those exercising with moderate intensity (PZ0 . 03). Serum T and fT began to decrease, and serum SHBG began to increase at the end of 12 weeks with both moderate-and high-intensity exercises. The serum LH and FSH concentrations decreased below the baseline level at 12 weeks in both groups (PZ0 . 07 in group 1 and 0 . 03 in group 2). Both groups had blunted LH and FSH responses to GnRH. These parameters improved to their pre-exercise level during the recovery period. Long-term strenuous treadmill exercises (overtraining syndrome) have a deleterious effect on reproduction.

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Section: Discussionmentioning

confidence: 71%

The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study

Safarinejad¹,

Azma²,

Kolahi³

2008

Journal of Endocrinology

137

112

View full text Add to dashboard Cite

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Section: Discussionmentioning

confidence: 99%

“…[18][19][20] Physical activity may reduce the level of circulating testosterone, 21,22 and although the association between sex hormones and prostate cancer risk is inconsistent, some studies have shown that low levels of testosterone may be associated with reduced risk for prostate cancer. [20][21][22][23] There is also evidence that exercise may reduce serum insulin and IGF-I levels. 24,25 Insulin appears to regulate the production and metabolism of testosterone, 26 whereas IGF-I stimulates proliferation and inhibits apoptosis in prostate cancer cells, and has been associated with increased prostate cancer risk in some, 19,27 but not all epidemiologic studies.…”

Section: Discussionmentioning

confidence: 99%

Recreational physical activity and risk of prostate cancer: A prospective population‐based study in Norway (the HUNT study)

Nilsen

Romundstad

Vatten

2006

Intl Journal of Cancer

102

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Physical activity has been studied in relation to prostate cancer risk, but the findings have been inconclusive. We prospectively examined the association between self-reported recreational physical activity and overall risk of prostate cancer, risk of advanced disease and risk of prostate cancer death in a cohort of 29,110 Norwegian men. Incident prostate cancers were obtained from the Norwegian Cancer Registry, and prostate cancer deaths were obtained from the national Cause of Death Registry. During 17 years of follow-up, 957 incident cases were identified, 266 of them were advanced (i.e. metastases at diagnosis) and 354 of the incident cases died from prostate cancer. In multivariable analysis, frequency and duration of exercise were inversely associated with the risk of advanced prostate cancer (p for trend 5 0.04 and 0.02). We computed a summary score that combined frequency, duration and intensity of exercise, and this score showed inverse associations with advanced prostate cancer risk and mortality (p for trend 5 0.02 and 0.07). Compared to men who reported no activity, the relative risks (95% confidence intervals) among men in the highest category of physical exercise was 0.64 (0.43-0.95) for advanced prostate cancer and 0.67 (0.48-0.94) for prostate cancer death. We found no association between physical activity and overall risk of prostate cancer. We conclude that recreational physical exercise is associated with reduced risk of advanced prostate cancer and prostate cancer death. ' 2006 Wiley-Liss, Inc.

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“…It is also possible that some biological mechanisms are site-specific; e.g. colon (Bennett and Del Tacca, 1975), gastro-intestinal tract (Reddy and Wynder, 1977) and prostate (Hackney et al, 1988).…”

Section: Mechanismsmentioning

confidence: 99%

Physical activity and risk of cancer in middle-aged men

2001

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Summary A prospective study was carried out to examine the relationship between physical activity and incidence of cancers in 7588 men aged 40-59 years with full data on physical activity and without cancer at screening. Physical activity at screening was classified as none/occasional, light, moderate, moderately-vigorous or vigorous. Cancer incidence data were obtained from death certificates, the national Cancer Registration Scheme and self-reporting on follow-up questionnaires of doctor-diagnosed cancer. Cancer (excluding skin cancers) developed in 969 men during mean follow-up of 18.8 years. After adjustment for age, smoking, body mass index, alcohol intake and social class, the risk of total cancers was significantly reduced only in men reporting moderately-vigorous or vigorous activity; no benefit seen at lesser levels. Sporting activity was essential to achieve significant benefit and was associated with a significant dose-response reduction in risk of prostate cancer and upper digestive and stomach cancer. Sporting (vigorous) activity was associated with a significant increase in bladder cancer. No association was seen with colo-rectal cancer. Non-sporting recreational activity showed no association with cancer. Physical activity in middle-aged men is associated with reduced risk of total cancers, prostate cancer, upper digestive and stomach cancer. Moderately-vigorous or vigorous levels involving sporting activities are required to achieve such benefit.

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Reproductive hormonal profiles of endurance-trained and untrained males

Cited by 201 publications

References 0 publications

The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study

The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study

Recreational physical activity and risk of prostate cancer: A prospective population‐based study in Norway (the HUNT study)

Physical activity and risk of cancer in middle-aged men

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