Reproductive issues in sickle cell disease

Smith‐Whitley, Kim

doi:10.1182/blood-2014-07-577619

Cited by 70 publications

(45 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adolescents and adults with SCD may experience a wide array of reproductive issues including delayed puberty, hypogonadism, infertility, and pregnancy complications [118][119][120][121]. In men with SCD, vaso-occlusion and recurrent testicular infarction may contribute to hypogonadism [122,123].…”

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimistic that the next 40 years will be focused on meeting current challenges in SCD by addressing chronic complications of SCD to reduce mortality and improve quality of life in a growing population of adults with SCD in high-income countries, while simultaneously decreasing the disparity of medical care between high and low-income countries.

show abstract

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

show abstract

“…As serious and even mortal SRH implications exist in these disease states, [36][37][38] analogous investigation into SRH care is needed. The findings of this study may help inform other subspecialty providers of both a patient need and an avenue to improve existing comprehensive care models.…”

Section: Theme 4: Women With Cf Prefer Early Open-minded Srh Discussmentioning

confidence: 99%

Provider and Patient Attitudes Regarding Sexual Health in Young Women With Cystic Fibrosis

et al. 2016

View full text Add to dashboard Cite

OBJECTIVE: To explore the attitudes, preferences, and experiences of patients with cystic fibrosis (CF) and CF providers toward sexual and reproductive health (SRH) care for young women with CF. METHODS:Young women with CF aged 18 to 30 years from a US CF care center and pediatric and adult CF program directors from a national sample participated in qualitative interviews investigating their experiences regarding SRH care and their attitudes and preferences toward SRH care provision in the CF setting. Interviews were audio-recorded, transcribed, and coded by using a thematic analysis approach.RESULTS: Twenty-two patient participants and 16 CF program directors were interviewed. Themes shared by both groups included the importance of SRH discussion in the CF care setting, patient and provider discomfort as a barrier to SRH care, and the need for SRH educational resources and provider training to improve SRH care. Providers highlighted the lack of standardization around SRH care in the current CF care model. Patients desired SRH educational resources coupled with early SRH discussions initiated by their CF provider. CONCLUSIONS:Both CF providers and patients agree that the CF provider has a fundamental role in providing CF-specific SRH care. Educational resources coupled with individualized SRH discussions may facilitate improved SRH care for young women with CF. Investigation into the implementation of SRH education and services into pediatric-onset chronic disease care models is needed.

show abstract

“…Studies among mice have shown that increased doses of HU increase testicular germ cell apoptosis, decrease sperm count, induce testicular atrophy, increase abnormal sperm morphology, and decrease sperm motility [29]. Sickle-cell-transgenic mice have hypogonadism at baseline.…”

Section: Hydroxyurea (Hu) and Fertility In Men With Scdmentioning

confidence: 99%

“…HU is a ribonucleotide reeducates inhibitor which acts as a S-phase-specific cytotoxic agent that impairs DNA synthesis [29]. Its effects are short lived and cease to exist once the drug is removed.…”

Section: Hydroxyurea (Hu) and Fertility In Men With Scdmentioning

confidence: 99%

“…Studies have shown that some of fertility issues emerge due to chronic medical therapies which are used to prevent or manage SCD-related morbidity [29]. Recent progress in SCD treatment, particularly with regard to the use of hydroxyurea (HU), has significantly improved the prognosis of patients with the condition [30,31].…”

Section: Hydroxyurea (Hu) and Fertility In Men With Scdmentioning

confidence: 99%

See 1 more Smart Citation

Infertility Issues in Men with Sickle Cell Disease

AlDallal

2017

IPCB

View full text Add to dashboard Cite

Patients with sickle cell disease (SCD), especially males, face a key problem in the form of infertility. Apart from low serum testosterone, abnormalities involving accessory sex organs are also observed in these patients. Infertility is a known complication among males with SCD, and it comes about due to reasons such as impotence, relative primary gonadal failure, priapism, and delayed or impaired sexual development. Infertility manifests due to multiple causes, including primary gonadal failure (hypogonadism), erectile dysfunction (ED) as a result of priapism, sperm abnormalities, and delayed or impaired sexual development. The ejaculate volume, sperm density, sperm motility, and normal sperm morphology were significantly reduced in these patients as compared with normal patients. Most importantly, primary testicular failure is marked by low levels of testosterone and infertility results mainly from diseases or conditions that affect and destroy the testis. The low levels of testosterone lead to fertility reduction, which is aggravated by impotence, secondary to earlier priapism. Studies among mice have shown that increased doses of HU increase testicular germ cell apoptosis, decrease sperm count, induce testicular atrophy, increase abnormal sperm morphology, and decrease sperm motility. A multifactorial etiology is responsible for impaired male fertility and it includes sperm abnormalities, ED, hypogonadism, and effect of therapy on sperm function. This paper summarizes some clinical manifestations which play an important role in the development of infertility among men with SCD. The author suggests that prospective studies among males with SCD should be carried out using various end points to determine cellular and functional impairment in fertility.

show abstract

Reproductive issues in sickle cell disease

Cited by 70 publications

References 78 publications

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Provider and Patient Attitudes Regarding Sexual Health in Young Women With Cystic Fibrosis

Infertility Issues in Men with Sickle Cell Disease

Contact Info

Product

Resources

About