Reproductive Outcome after Hysteroscopic Metroplasty in Patients with Infertility and Recurrent Pregnancy Loss

Abstract

Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA), increasing the number of unsuccessful pregnancies and obstetric complications. Compared with the population with normally formed uterus, patients with CUA have higher abortion rate, higher fetal loss rate and decreased live birth rate. Hysteroscopic metroplasty (HM) is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies.Aim: The aim of the study was to analyze the reproductive outcome in group of patients with infertility and recurrent pregnancy loss and present CUA, before and after hysteroscopic metroplasty.Material and Methods: We analyzed 67 patients to whom 78 interventions hysteroscopic metroplasty were performed at the University Clinic of Obstetrics and Gynecology in Skopje during a two year period, between 01.01.2010 and 31.12.2011. Their reproductive outcome was monitored during a two-year period and the same group served as a control group, taking into account their previous reproductive history. Statistical analysis was performed using Chi-square test and p < 0.05 was considered to be statistically significant.Results: Most common CUA were types 5b and 6 represented by 88 %. In a follow up period of two years, 33 of the patients become pregnant. There was a statistically significant decrease of abortion rate from 92% to 21.2%, as well as an increase in the term delivery rate from 0% to 69.7%.Conclusion: Treatment with hysteroscopic metroplasty is significantly improving the reproductive outcome in patients with CUA and previous fetal loss

Congenital anomalies of reproductive system among infertile women attending Dr. Khawer Center for Infertility and IVF in Maternity Teaching Hospital in Erbil city: A retrospective study

“…In a recent study, a significant reduction of abortion rate found to be from 92% to 21.2%, and the term delivery rate increased from 0% to 69.7%. 23 This is the first study that had been conducted in the infertility center of Maternity Teaching Hospital in Erbil city to determine the prevalence and pattern of congenital malformations among infertile women. The study has limitations as based on data collection retrospectively from patient files, as many cases were excluded due to incomplete recording of information, missing data, no computerized data about patients.…”

Reproduction in women with congenital uterus and vagina anomalies

“…Так, у женщин с аномалиями развития матки отмечается высокая частота встречаемости самопроизвольных абортов, преждевременных родов, преждевременной отслойки нормально расположенной плаценты, гибели плода. По данным литературы [4], частота наступления самостоятельной беременности у женщин с пороками развития матки составляет около 50%. Частота своевременных родов у женщин с внутриматочной перегородкой без хирургической коррекции и двурогой маткой составляет около 40% и у пациенток с седловидной маткой -65% [4,5].…”

“…По данным литературы [4], частота наступления самостоятельной беременности у женщин с пороками развития матки составляет около 50%. Частота своевременных родов у женщин с внутриматочной перегородкой без хирургической коррекции и двурогой маткой составляет около 40% и у пациенток с седловидной маткой -65% [4,5]. У пациенток с бесплодием наиболее частой аномалией развития матки является внутриматочная перегородка, которая может быть удалена хирургически, хотя до настоящего времени остается дискутабельным вопрос о необходимости проведения хирургической коррекции [6][7][8].…”

“…И только благодаря исследованию крови на хорионический гонадотропин устанавливается так называемая биохимическая беременность. Только 2-3% потерь беременности происходит после 8-й недели беременности и в последующие 2 мес [4].…”

The Reproductive Outcome in patients having Primary Infertility or Recurrent Miscarriages after performing Hysteroscopic Septal Resection

“…In general, they are asymptomatic [2], but they can also be associated with recurrent abortions or infertility [3]. They are diagnosed in more than 25% of females that are having repeated pregnancy loss [4]. Uterine septum forms about 2-3% of the most commonly diagnosed congenital uterine malformation in the general population and it is associated with obstetrical complications and infertility [5].…”