Reproductive status in adult male long-term survivors of childhood cancer

Tromp, Krista; Claessens, J J M; Knijnenburg, Sebastiaan L.; Pal, Helena J.H. van der; Leeuwen, Flora E. van; Caron, Huib N.; Beerendonk, C.C.M.; Kremer, Leontien C. M.

doi:10.1093/humrep/der113

Cited by 31 publications

(35 citation statements)

References 22 publications

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“…While childhood cancer had an almost sevenfold increased odds of developing hypogonadism in adulthood compared with controls (Romerius et al, 2009), chemotherapy agents used to treat cancer were not found to be associated with development of hypogonadism (Puhse et al, 2011;Tromp et al, 2011). Total body irradiation was significantly associated with lower mean T level compared with controls in one study assessing a series of different cancer treatment modalities (b = À3.53; p = 0.036; Tromp et al, 2011).…”

Section: Disease-specific Studiesmentioning

confidence: 98%

“…Total body irradiation was significantly associated with lower mean T level compared with controls in one study assessing a series of different cancer treatment modalities (b = À3.53; p = 0.036; Tromp et al, 2011).…”

Section: Disease-specific Studiesmentioning

confidence: 99%

“…Five longitudinal, population or community-based studies (Harman et al, 2001;Laaksonen et al, 2005;Travison et al, 2008;Haring et al, 2010a;Ponholzer et al, 2010) and four disease-specific studies (Romerius et al, 2009;Puhse et al, 2011;Tromp et al, 2011;Pellitero et al, 2012) were identified that assessed potential risk factors of hypogonadism within the study (Table 3). The studies were conducted in Austria, Finland, Germany, Netherlands, Spain, Sweden, and USA.…”

Section: Risk Factorsmentioning

confidence: 99%

“…Three studies assessed a history of cancer or cancer therapy as potential risk factors in the development of hypogonadism (Romerius et al, 2009;Puhse et al, 2011;Tromp et al, 2011). The sample sizes ranged from 160 to 565 and follow-up times ranged from 2 to 34 years.…”

Section: Disease-specific Studiesmentioning

confidence: 99%

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Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men

et al. 2014

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SUMMARYThe objective of this review was to summarize the literature on the risk factors, comorbidities, and consequences of male hypogonadism, which is defined as a syndrome complex that includes biochemical confirmation of low testosterone (T) and the consistent symptoms and signs associated with low T. A systematic literature search was performed in PubMed/MEDLINE, EMBASE, Cochrane Library for articles published in the last 10 years on risk factors, comorbidities, and consequences of male hypogonadism. Of the 53 relevant studies identified, nine examined potential risk factors, 14 examined potential comorbidities, and 30 examined potential consequences of male hypogonadism. Based on studies conducted in Asia, Australia, Europe, and North & South America, the important factors that predicted and correlated with hypogonadism were advanced age, obesity, a diagnosis of metabolic syndrome (MetS), and a poor general health status. Diabetes mellitus was correlated with hypogonadism in most studies, but was not established as a risk factor. Although diseases, such as coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with incident low T. The data reviewed on potential consequences suggest that low T levels may be linked to earlier all-cause and cardiovascular related mortality among men. This literature review suggests that men with certain factors, such as advanced age, obesity, MetS, and poor general health, are more likely to have and develop hypogonadism. Low levels of T may have important long-term negative health consequences.

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Section: Disease-specific Studiesmentioning

confidence: 98%

Section: Disease-specific Studiesmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: Disease-specific Studiesmentioning

confidence: 99%

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Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men

et al. 2014

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“…Most studies were performed in paediatric stem cell transplantation or are retrospective analyses with a small number of cases [1,2,3,4,5,6,7]. The complications mentioned were mostly urological infections and haematuria [8].…”

Section: Introductionmentioning

confidence: 99%

Urological Complications and BK Virus-Associated Diseases Under Allogenic Stem Cell Transplantation

Schneidewind

Neumann²,

Burchardt³

et al. 2016

Urol Int

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Every year 50,000 patients receive a stem cell transplantation worldwide, but there is lack of data pertaining to urological complications. Methods: We performed a retrospective analysis of all adult patients undergoing their first allogenic stem cell transplantation from January 2011 to June 2013 in our institution. Statistical tests performed were Pearson's correlation, chi-square testing and logistic regression using SPSS 22.0. Results: We identified 39 patients (22 males, 17 females). Twenty four patients (61.5%) had a urological complication. Most frequent urologic complications were bacterial urinary tract infection (n = 13; 33.3%), acute renal failure (n = 6; 15.4%) and BK virus-associated haemorrhagic cystitis (n = 5; 12.8%). BK viruria was detected in 12 patients (30.8%). We observed an association of creatinine increase (about 20 µmol/l at time of onset of BK viruria) with BK viruria (Pearson's correlation 0.64; p = 0.01), and BK viruria is significantly linked to acute renal failure (Pearson's correlation 0.35; p = 0.029). In univariate regression, BK viruria is significantly linked to urological complication (p = 0.025). Conclusions: We suggest that BK virus infection during stem cell transplantation can lead to BK virus associated nephropathy, which is so far only known from patients after kidney transplantation.

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Treating Sexual Problems in Cancer Patients and Survivors

Zhou¹,

Bober²

2017

The Wiley Handbook of Sex Therapy

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Reproductive status in adult male long-term survivors of childhood cancer

Abstract: One-third of young adult male survivors of childhood cancer has elevated FSH levels. FSH appears to be a very sensitive marker for the need of assisted reproductive techniques in male childhood cancer survivors.

Cited by 31 publications

References 22 publications

Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men

Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men

Urological Complications and BK Virus-Associated Diseases Under Allogenic Stem Cell Transplantation

Treating Sexual Problems in Cancer Patients and Survivors

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